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This study investigates the role of\n                    <jats:italic>MBL2<\/jats:italic>\n                    genetic variants and levels of MBL in serum and complement proteins in Vietnamese dengue patients.\n                    <jats:italic>MBL2<\/jats:italic>\n                    genotypes (\u2212\u2009550\n                    <jats:italic>L\/H, MBL2<\/jats:italic>\n                    codon 54\n                    <jats:italic>), MBL2<\/jats:italic>\n                    diplotypes (\n                    <jats:italic>XA\/XO<\/jats:italic>\n                    ,\n                    <jats:italic>YA\/XO<\/jats:italic>\n                    ) and\n                    <jats:italic>MBL2<\/jats:italic>\n                    haplotypes (\n                    <jats:italic>LXPB<\/jats:italic>\n                    ,\n                    <jats:italic>HXPA<\/jats:italic>\n                    ,\n                    <jats:italic>XO<\/jats:italic>\n                    ) were associated with dengue in the study population. The levels of complement factors C2, C5, and C5a were higher in dengue and dengue with warning signs (DWS) patients compared to those in healthy controls, while factor D levels were decreased in dengue and DWS patients compared to the levels determined in healthy controls. C2 and C5a levels were associated with the levels of AST and ALT and with WBC counts. C9 levels were negatively correlated with ALT levels and WBC counts, and factor D levels were associated with AST and ALT levels and with platelet counts. In conclusions,\n                    <jats:italic>MBL2<\/jats:italic>\n                    polymorphisms are associated with dengue in the Vietnamese study population. The levels of the complement proteins C2, C4b, C5, C5a, C9, factor D and factor I are modulated in dengue patients during the clinical course of dengue.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-71947-2","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T06:03:14Z","timestamp":1599717794000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Complement protein levels and MBL2 polymorphisms are associated with dengue and disease severity"],"prefix":"10.1038","volume":"10","author":[{"given":"Ngo Truong","family":"Giang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang","family":"van Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do","family":"Quyet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nghiem Xuan","family":"Hoan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trinh Huu","family":"Nghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Minh","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoang Vu","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Tuan","family":"Anh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Van Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Anh","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian G.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirumalaisamy P.","family":"Velavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Linh","family":"Toan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"71947_CR1","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nature12060","volume":"496","author":"S Bhatt","year":"2013","unstructured":"Bhatt, S. et al. 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