{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:34:42Z","timestamp":1793144082413,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"JSPS KAKENHI","award":["JP15K09535"],"award-info":[{"award-number":["JP15K09535"]}]},{"name":"The Ministry of Health, Labor and Welfare of Japan","award":["Health and Labor Sciences Research Grants for research on intractable diseases (The Research Team for Autoimmune Diseases)"],"award-info":[{"award-number":["Health and Labor Sciences Research Grants for research on intractable diseases (The Research Team for Autoimmune Diseases)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patient-reported outcome (PRO) is included in the remission criteria of rheumatoid arthritis (RA). We aimed to determine the effect of age on PRO and the subsequent achievement of clinical and functional RA remission criteria. Three hundred and one patients with non-rheumatic diseases were evaluated using the 0\u201310\u00a0cm visual analog scale (VAS) assessment for musculoskeletal symptoms and a functional health assessment questionnaire-disability index (HAQ-DI). These assessments were compared with those obtained from 149 patients with RA with negative tender\/swollen joint counts and normal serum C-reactive levels (objective clinical remission). Of the 301 patients, 32.2%, 26.6%, and 41.2% were classified as non-elderly (&lt;\u200965\u00a0years), early elderly (65\u201374\u00a0years), and late-elderly (\u2265\u200975\u00a0years) patients, respectively. VAS\u2009&gt;\u20091\u00a0cm and HAQ-DI\u2009\u2265\u20090.5 were observed in 7.3% and 14.5%, respectively, in late-elderly patients, whereas \u2264\u20091.0% of non-elderly and early elderly patients for the both. Among 149 RA patients in objective remission, however, &gt;\u200920% and &gt;\u200910% of early elderly patients (and even non-elderly patients) had VAS\u2009&gt;\u20091\u00a0cm and HAQ-DI\u2009\u2265\u20090.5, respectively, and 34.0% and 35.8% of late-elderly patients with RA had VAS\u2009&gt;\u20091\u00a0cm and HAQ-DI\u2009\u2265\u20090.5, respectively. Multivariate logistic analysis revealed that age and RA were associated with the non-achievement of VAS\u2009\u2264\u20091\u00a0cm and HAQ-DI\u2009&lt;\u20090.5. Therefore, the effect of age, which was independent of the presence of RA even without any objective disease activity, on PRO and the non-achievement of clinical and functional remission criteria was demonstrated.<\/jats:p>","DOI":"10.1038\/s41598-020-72274-2","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T21:28:45Z","timestamp":1600378125000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association of age with the non-achievement of clinical and functional remission in rheumatoid arthritis"],"prefix":"10.1038","volume":"10","author":[{"given":"Tadashi","family":"Aoki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehisa","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nishiwaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Kameda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"72274_CR1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.rdc.2016.01.010","volume":"42","author":"LHD van Tuyl","year":"2016","unstructured":"van Tuyl, L. 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K. H. K. has received consulting fees, speaking fees, and\/or honoraria from AbbVie G.K., Asahi Kasei Pharma, Astellas Pharma, Bristol-Myers Squibb, Chugai Pharmaceutical Co., Ltd., Eisai Co. Ltd., Eli Lilly Japan K.K., Gilead Sciences, Janssen Pharmaceutical K.K., Mitsubishi Tanabe Pharma, Novartis Pharma K.K., and Sanofi Pharma, and has received research grants from AbbVie G.K., Asahi Kasei Pharma, Astellas Pharma Inc., Chugai Pharmaceutical Co., Ltd., Eisai Co., Ltd., Mitsubishi Tanabe Pharma, Novartis Pharma K.K. and Sanofi Pharma. T. A., H. I., T. O., A. H. and Y. N. declare no potential conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15277"}}