{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:15:30Z","timestamp":1774653330732,"version":"3.50.1"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["JP264611249"],"award-info":[{"award-number":["JP264611249"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["19K11662"],"award-info":[{"award-number":["19K11662"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19ek0210118"],"award-info":[{"award-number":["JP19ek0210118"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19gm6210010"],"award-info":[{"award-number":["JP19gm6210010"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19bm0804010"],"award-info":[{"award-number":["JP19bm0804010"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19gm0810013"],"award-info":[{"award-number":["JP19gm0810013"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19km0405209"],"award-info":[{"award-number":["JP19km0405209"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19bm0704026"],"award-info":[{"award-number":["JP19bm0704026"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19ek0109406"],"award-info":[{"award-number":["JP19ek0109406"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some clinical trials showed that omega-3 fatty acid (FA) reduced cardiovascular events, but it remains unknown whether omega-3 FA supplementation changes the composition of FAs and their metabolites in the heart and how the changes, if any, exert beneficial effects on cardiac structure and function. To clarify these issues, we supplied omega-3 FA to mice exposed to pressure overload, and examined cardiac structure and function by echocardiography and a proportion of FAs and their metabolites by gas chromatography and liquid chromatography-tandem mass spectrometry, respectively. Pressure overload induced cardiac hypertrophy and dysfunction, and reduced concentration of all FAs\u2019 components and increased free form arachidonic acid and its metabolites, precursors of pro-inflammatory mediators in the heart. Omega-3 FA supplementation increased both total and free form of eicosapentaenoic acid, a precursor of pro-resolution mediators and reduced free form arachidonic acid in the heart. Omega-3 FA supplementation suppressed expressions of pro-inflammatory cytokines and the infiltration of inflammatory cells into the heart and ameliorated cardiac dysfunction and fibrosis. These results suggest that omega-3 FA-induced changes of FAs composition in the heart have beneficial effects on cardiac function via regulating inflammation.<\/jats:p>","DOI":"10.1038\/s41598-020-72686-0","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T10:03:36Z","timestamp":1600855416000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Omega-3 fatty acid prevents the development of heart failure by changing fatty acid composition in the heart"],"prefix":"10.1038","volume":"10","author":[{"given":"Haruhiro","family":"Toko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Katakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Bujo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Ishizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiki","family":"Takimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Shido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuo","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issei","family":"Komuro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"72686_CR1","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nrcardio.2016.25","volume":"13","author":"B Ziaeian","year":"2016","unstructured":"Ziaeian, B. & Fonarow, G. C. Epidemiology and aetiology of heart failure. Nat. Rev. Cardiol. 13, 368\u2013378 (2016).","journal-title":"Nat. Rev. Cardiol."},{"key":"72686_CR2","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","volume":"99","author":"DP Del Re","year":"2019","unstructured":"Del Re, D. P., Amgalan, D., Linkermann, A., Liu, Q. & Kitsis, R. N. Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol. Rev. 99, 1765\u20131817 (2019).","journal-title":"Physiol. Rev."},{"key":"72686_CR3","doi-asserted-by":"publisher","first-page":"11389","DOI":"10.1073\/pnas.1513047112","volume":"112","author":"G Santulli","year":"2015","unstructured":"Santulli, G., Xie, W., Reiken, S. R. & Marks, A. R. Mitochondrial calcium overload is a key determinant in heart failure. Proc. Natl. Acad. Sci. U.S.A. 112, 11389\u201311394 (2015).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"72686_CR4","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1002\/ejhf.942","volume":"19","author":"Y Zhang","year":"2017","unstructured":"Zhang, Y., Bauersachs, J. & Langer, H. F. Immune mechanisms in heart failure. Eur. J. Heart Fail. 19, 1379\u20131389 (2017).","journal-title":"Eur. J. Heart Fail."},{"key":"72686_CR5","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11897-017-0337-9","volume":"14","author":"S Van Linthout","year":"2017","unstructured":"Van Linthout, S. & Tschope, C. Inflammation\u2014Cause or Consequence of Heart Failure or Both?. Curr. Heart Fail. Rep. 14, 251\u2013265 (2017).","journal-title":"Curr. Heart Fail. Rep."},{"key":"72686_CR6","doi-asserted-by":"publisher","first-page":"H2181","DOI":"10.1152\/ajpheart.00554.2011","volume":"301","author":"H Tsutsui","year":"2011","unstructured":"Tsutsui, H., Kinugawa, S. & Matsushima, S. Oxidative stress and heart failure. Am. J. Physiol. Heart Circ. Physiol. 301, H2181-2190 (2011).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"72686_CR7","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1093\/cvr\/cvn310","volume":"81","author":"MK Duda","year":"2009","unstructured":"Duda, M. K. et al. Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction. Cardiovasc. Res. 81, 319\u2013327 (2009).","journal-title":"Cardiovasc. Res."},{"key":"72686_CR8","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1093\/eurheartj\/ehy085","volume":"39","author":"L Wang","year":"2018","unstructured":"Wang, L. et al. CXCL1-CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration. Eur. Heart J. 39, 1818\u20131831 (2018).","journal-title":"Eur. Heart J."},{"key":"72686_CR9","doi-asserted-by":"publisher","first-page":"e000267","DOI":"10.1161\/JAHA.113.000267","volume":"2","author":"Y Higashikuni","year":"2013","unstructured":"Higashikuni, Y. et al. Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1beta upregulation via nuclear factor kappaB activation. J. Am. Heart Assoc. 2, e000267 (2013).","journal-title":"J. Am. Heart Assoc."},{"key":"72686_CR10","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3109\/07853890.2010.538080","volume":"43","author":"RA de Boer","year":"2011","unstructured":"de Boer, R. A. et al. Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction. Ann. Med. 43, 60\u201368 (2011).","journal-title":"Ann. Med."},{"key":"72686_CR11","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.amjcard.2003.12.010","volume":"93","author":"KE Joynt","year":"2004","unstructured":"Joynt, K. E. et al. Effect of angiotensin-converting enzyme inhibitors, beta blockers, statins, and aspirin on C-reactive protein levels in outpatients with heart failure. Am. J. Cardiol. 93, 783\u2013785 (2004).","journal-title":"Am. J. Cardiol."},{"key":"72686_CR12","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.3390\/molecules23102583","volume":"23","author":"C de Carvalho","year":"2018","unstructured":"de Carvalho, C. & Caramujo, M. J. The various roles of fatty acids. Molecules 23, 2583 (2018).","journal-title":"Molecules"},{"key":"72686_CR13","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.plefa.2018.03.004","volume":"132","author":"JK Innes","year":"2018","unstructured":"Innes, J. K. & Calder, P. C. Omega-6 fatty acids and inflammation. Prostaglandins Leukot. Essent. Fatty Acids 132, 41\u201348 (2018).","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"72686_CR14","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nri2294","volume":"8","author":"CN Serhan","year":"2008","unstructured":"Serhan, C. N., Chiang, N. & Van Dyke, T. E. Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol. 8, 349\u2013361 (2008).","journal-title":"Nat. Rev. Immunol."},{"key":"72686_CR15","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1172\/JCI97943","volume":"128","author":"CN Serhan","year":"2018","unstructured":"Serhan, C. N. & Levy, B. D. Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. J. Clin. Invest. 128, 2657\u20132669 (2018).","journal-title":"J. Clin. Invest."},{"key":"72686_CR16","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature13479","volume":"510","author":"CN Serhan","year":"2014","unstructured":"Serhan, C. N. Pro-resolving lipid mediators are leads for resolution physiology. Nature 510, 92\u2013101 (2014).","journal-title":"Nature"},{"key":"72686_CR17","doi-asserted-by":"publisher","first-page":"106337","DOI":"10.1016\/j.prostaglandins.2019.106337","volume":"143","author":"JE Watson","year":"2019","unstructured":"Watson, J. E., Kim, J. S. & Das, A. Emerging class of omega-3 fatty acid endocannabinoids & their derivatives. Prostaglandins Other Lipid Mediat. 143, 106337 (2019).","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"72686_CR18","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1080\/00325481.2019.1607414","volume":"131","author":"JR Nelson","year":"2019","unstructured":"Nelson, J. R. & Raskin, S. The eicosapentaenoic acid:arachidonic acid ratio and its clinical utility in cardiovascular disease. Postgrad. Med. 131, 268\u2013277 (2019).","journal-title":"Postgrad. Med."},{"key":"72686_CR19","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1084\/jem.20082596","volume":"206","author":"Y Kayama","year":"2009","unstructured":"Kayama, Y. et al. Cardiac 12\/15 lipoxygenase-induced inflammation is involved in heart failure. J. Exp. Med. 206, 1565\u20131574 (2009).","journal-title":"J. Exp. Med."},{"key":"72686_CR20","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1084\/jem.20132011","volume":"211","author":"J Endo","year":"2014","unstructured":"Endo, J. et al. 18-HEPE, an n-3 fatty acid metabolite released by macrophages, prevents pressure overload-induced maladaptive cardiac remodeling. J. Exp. Med. 211, 1673\u20131687 (2014).","journal-title":"J. Exp. Med."},{"key":"72686_CR21","doi-asserted-by":"publisher","first-page":"22442","DOI":"10.1074\/jbc.273.35.22442","volume":"273","author":"P Kunapuli","year":"1998","unstructured":"Kunapuli, P., Lawson, J. A., Rokach, J. A., Meinkoth, J. L. & FitzGerald, G. A. Prostaglandin F2alpha (PGF2alpha) and the isoprostane, 8, 12-iso-isoprostane F2alpha-III, induce cardiomyocyte hypertrophy. Differential activation of downstream signaling pathways. J. Biol. Chem. 273, 22442\u201322452 (1998).","journal-title":"J. Biol. Chem."},{"key":"72686_CR22","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1812792","volume":"380","author":"DL Bhatt","year":"2019","unstructured":"Bhatt, D. L. et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N. Engl. J. Med. 380, 11\u201322 (2019).","journal-title":"N. Engl. J. Med."},{"key":"72686_CR23","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1016\/S0140-6736(07)60527-3","volume":"369","author":"M Yokoyama","year":"2007","unstructured":"Yokoyama, M. et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis. Lancet 369, 1090\u20131098 (2007).","journal-title":"Lancet"},{"key":"72686_CR24","doi-asserted-by":"crossref","unstructured":"Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 354, 447\u2013455 (1999).","DOI":"10.1016\/S0140-6736(99)07072-5"},{"key":"72686_CR25","first-page":"CD012815","volume":"6","author":"CG Alvarez Campano","year":"2019","unstructured":"Alvarez Campano, C. G., Macleod, M. J., Aucott, L. & Thies, F. Marine-derived n-3 fatty acids therapy for stroke. Cochrane Database Syst. Rev. 6, CD012815 (2019).","journal-title":"Cochrane Database Syst. Rev."},{"key":"72686_CR26","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1007\/s10654-012-9748-9","volume":"27","author":"SC Larsson","year":"2012","unstructured":"Larsson, S. C., Orsini, N. & Wolk, A. Long-chain omega-3 polyunsaturated fatty acids and risk of stroke: A meta-analysis. Eur. J. Epidemiol. 27, 895\u2013901 (2012).","journal-title":"Eur. J. Epidemiol."},{"key":"72686_CR27","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1161\/CIRCRESAHA.113.301084","volume":"112","author":"H Toko","year":"2013","unstructured":"Toko, H. et al. Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circ. Res. 112, 1244\u20131252 (2013).","journal-title":"Circ. Res."},{"key":"72686_CR28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.33549\/physiolres.930792","volume":"55","author":"MG Nikolaidis","year":"2006","unstructured":"Nikolaidis, M. G., Petridou, A. & Mougios, V. Comparison of the phospholipid and triacylglycerol fatty acid profile of rat serum, skeletal muscle and heart. Physiol. Res. 55, 259\u2013265 (2006).","journal-title":"Physiol. Res."},{"key":"72686_CR29","doi-asserted-by":"publisher","first-page":"275","DOI":"10.5551\/jat.34231","volume":"24","author":"TC Su","year":"2017","unstructured":"Su, T. C. et al. A randomized, double-blind, placebo-controlled clinical trial to assess the efficacy and safety of ethyl-ester omega-3 fatty acid in taiwanese hypertriglyceridemic patients. J. Atheroscler. Thromb. 24, 275\u2013289 (2017).","journal-title":"J. Atheroscler. Thromb."},{"key":"72686_CR30","first-page":"523","volume":"44","author":"Y Kimura","year":"2016","unstructured":"Kimura, Y., Nishimoto, T. & Tozawa, R. Plasma lipid lowering effect and mechanism of TAK\u2014085 in Obese\u2014hyperlipidemic wistar fatty rats. Jpn. Pharmacol. Ther. 44, 523\u2013529 (2016).","journal-title":"Jpn. Pharmacol. Ther."},{"key":"72686_CR31","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0022-2275(20)38861-1","volume":"27","author":"G Lepage","year":"1986","unstructured":"Lepage, G. & Roy, C. C. Direct transesterification of all classes of lipids in a one-step reaction. J. Lipid Res. 27, 114\u2013120 (1986).","journal-title":"J. Lipid Res."},{"key":"72686_CR32","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.plefa.2014.07.015","volume":"91","author":"T Inoue","year":"2014","unstructured":"Inoue, T. et al. Effects of chronic administration of arachidonic acid on lipid profiles and morphology in the skeletal muscles of aged rats. Prostaglandins Leukot. Essent. Fatty Acids 91, 119\u2013127 (2014).","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"72686_CR33","doi-asserted-by":"publisher","first-page":"e0140884","DOI":"10.1371\/journal.pone.0140884","volume":"10","author":"M Katakura","year":"2015","unstructured":"Katakura, M. et al. Chronic arachidonic acid administration decreases docosahexaenoic acid- and eicosapentaenoic acid-derived metabolites in kidneys of aged rats. PLoS ONE 10, e0140884 (2015).","journal-title":"PLoS ONE"},{"key":"72686_CR34","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.bbalip.2014.10.009","volume":"1851","author":"M Hashimoto","year":"2015","unstructured":"Hashimoto, M. et al. n-3 fatty acids effectively improve the reference memory-related learning ability associated with increased brain docosahexaenoic acid-derived docosanoids in aged rats. Biochim. Biophys. Acta 1851, 203\u2013209 (2015).","journal-title":"Biochim. Biophys. Acta"},{"key":"72686_CR35","first-page":"8107265","volume":"2019","author":"A Leuti","year":"2019","unstructured":"Leuti, A., Maccarrone, M. & Chiurchiu, V. Proresolving lipid mediators: endogenous modulators of oxidative stress. Oxid. Med. Cell. Longev. 2019, 8107265 (2019).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"72686_CR36","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.mam.2018.03.003","volume":"64","author":"JM Galano","year":"2018","unstructured":"Galano, J. M. et al. Biological activities of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) derived from EPA and DHA: New anti-arrhythmic compounds?. Mol. Aspects Med. 64, 161\u2013168 (2018).","journal-title":"Mol. Aspects Med."},{"key":"72686_CR37","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa, H., Ohishi, N. & Yagi, K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95, 351\u2013358 (1979).","journal-title":"Anal. Biochem."},{"key":"72686_CR38","first-page":"324","volume":"3","author":"A Ariel","year":"2012","unstructured":"Ariel, A., Maridonneau-Parini, I., Rovere-Querini, P., Levine, J. S. & Muhl, H. Macrophages in inflammation and its resolution. Front. Immunol. 3, 324 (2012).","journal-title":"Front. Immunol."},{"key":"72686_CR39","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1002\/emmm.201202382","volume":"5","author":"A Ortega-Gomez","year":"2013","unstructured":"Ortega-Gomez, A., Perretti, M. & Soehnlein, O. Resolution of inflammation: an integrated view. EMBO Mol. Med. 5, 661\u2013674 (2013).","journal-title":"EMBO Mol. Med."},{"key":"72686_CR40","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neulet.2017.02.076","volume":"645","author":"L Lisi","year":"2017","unstructured":"Lisi, L. et al. Expression of iNOS, CD163 and ARG-1 taken as M1 and M2 markers of microglial polarization in human glioblastoma and the surrounding normal parenchyma. Neurosci. Lett. 645, 106\u2013112 (2017).","journal-title":"Neurosci. Lett."},{"key":"72686_CR41","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","volume":"113","author":"T Doenst","year":"2013","unstructured":"Doenst, T., Nguyen, T. D. & Abel, E. D. Cardiac metabolism in heart failure: Implications beyond ATP production. Circ. Res. 113, 709\u2013724 (2013).","journal-title":"Circ. Res."},{"key":"72686_CR42","doi-asserted-by":"publisher","first-page":"H1626","DOI":"10.1152\/ajpheart.00332.2003","volume":"285","author":"WC Stanley","year":"2003","unstructured":"Stanley, W. C., Meadows, S. R., Kivilo, K. M., Roth, B. A. & Lopaschuk, G. D. Beta-Hydroxybutyrate inhibits myocardial fatty acid oxidation in vivo independent of changes in malonyl-CoA content. Am. J. Physiol. Heart Circ. Physiol. 285, H1626-1631 (2003).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"72686_CR43","doi-asserted-by":"publisher","first-page":"12035","DOI":"10.1038\/s41598-018-30616-1","volume":"8","author":"Y Umbarawan","year":"2018","unstructured":"Umbarawan, Y. et al. Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure. Sci. Rep. 8, 12035 (2018).","journal-title":"Sci. Rep."},{"key":"72686_CR44","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1161\/CIRCHEARTFAILURE.109.888479","volume":"3","author":"T Kato","year":"2010","unstructured":"Kato, T. et al. Analysis of metabolic remodeling in compensated left ventricular hypertrophy and heart failure. Circ. Heart Fail. 3, 420\u2013430 (2010).","journal-title":"Circ. Heart Fail."},{"key":"72686_CR45","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1124\/jpet.110.170605","volume":"335","author":"RJ Khairallah","year":"2010","unstructured":"Khairallah, R. J. et al. Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium. J. Pharmacol. Exp. Ther. 335, 155\u2013162 (2010).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"72686_CR46","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1007\/s12265-013-9511-y","volume":"6","author":"WC Stanley","year":"2013","unstructured":"Stanley, W. C. et al. Evaluation of docosahexaenoic acid in a dog model of hypertension induced left ventricular hypertrophy. J. Cardiovasc. Transl. Res. 6, 1000\u20131010 (2013).","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"72686_CR47","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.cardiores.2007.07.002","volume":"76","author":"MK Duda","year":"2007","unstructured":"Duda, M. K. et al. Dietary supplementation with omega-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload. Cardiovasc. Res. 76, 303\u2013310 (2007).","journal-title":"Cardiovasc. Res."},{"key":"72686_CR48","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1093\/cvr\/cvs280","volume":"96","author":"M Velten","year":"2012","unstructured":"Velten, M. et al. Priming with synthetic oligonucleotides attenuates pressure overload-induced inflammation and cardiac hypertrophy in mice. Cardiovasc. Res. 96, 422\u2013432 (2012).","journal-title":"Cardiovasc. Res."},{"key":"72686_CR49","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1002\/path.4108","volume":"229","author":"A Ariel","year":"2013","unstructured":"Ariel, A. & Timor, O. Hanging in the balance: Endogenous anti-inflammatory mechanisms in tissue repair and fibrosis. J. Pathol. 229, 250\u2013263 (2013).","journal-title":"J. Pathol."},{"key":"72686_CR50","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1007\/s00109-012-0954-4","volume":"90","author":"S Uderhardt","year":"2012","unstructured":"Uderhardt, S. & Kronke, G. 12\/15-lipoxygenase during the regulation of inflammation, immunity, and self-tolerance. J. Mol. Med. (Berl.) 90, 1247\u20131256 (2012).","journal-title":"J. Mol. Med. (Berl.)"},{"key":"72686_CR51","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2015.04.003","volume":"84","author":"V Kain","year":"2015","unstructured":"Kain, V. et al. Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. J. Mol. Cell. Cardiol. 84, 24\u201335 (2015).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"72686_CR52","doi-asserted-by":"publisher","first-page":"j1909","DOI":"10.1136\/bmj.j1909","volume":"357","author":"M Bally","year":"2017","unstructured":"Bally, M. et al. Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data. BMJ 357, j1909 (2017).","journal-title":"BMJ"},{"key":"72686_CR53","doi-asserted-by":"publisher","first-page":"481","DOI":"10.7326\/0003-4819-142-7-200504050-00113","volume":"142","author":"LE Levesque","year":"2005","unstructured":"Levesque, L. E., Brophy, J. M. & Zhang, B. The risk for myocardial infarction with cyclooxygenase-2 inhibitors: a population study of elderly adults. Ann. Intern. Med. 142, 481\u2013489 (2005).","journal-title":"Ann. Intern. Med."},{"key":"72686_CR54","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/j.1752-8062.2011.00294.x","volume":"4","author":"R Kerkela","year":"2011","unstructured":"Kerkela, R. et al. Cytosolic phospholipase A(2)alpha protects against ischemia\/reperfusion injury in the heart. Clin. Transl. Sci. 4, 236\u2013242 (2011).","journal-title":"Clin. Transl. Sci."},{"key":"72686_CR55","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1161\/HYPERTENSIONAHA.113.01639","volume":"63","author":"Y Katsumata","year":"2014","unstructured":"Katsumata, Y. et al. Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2. Hypertension 63, 80\u201387 (2014).","journal-title":"Hypertension"},{"key":"72686_CR56","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1124\/jpet.116.238261","volume":"360","author":"D Kong","year":"2017","unstructured":"Kong, D. et al. Niacin promotes cardiac healing after myocardial infarction through activation of the myeloid prostaglandin D2 receptor subtype 1. J. Pharmacol. Exp. Ther. 360, 435\u2013444 (2017).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"72686_CR57","doi-asserted-by":"publisher","first-page":"2358","DOI":"10.1111\/bph.13844","volume":"174","author":"C Wang","year":"2017","unstructured":"Wang, C. et al. Hydroxyeicosapentaenoic acids and epoxyeicosatetraenoic acids attenuate early occurrence of nonalcoholic fatty liver disease. Br. J. Pharmacol. 174, 2358\u20132372 (2017).","journal-title":"Br. J. Pharmacol."},{"key":"72686_CR58","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1097\/00007890-199609270-00006","volume":"62","author":"K Ku","year":"1996","unstructured":"Ku, K. et al. The effects of omega-3 polyunsaturated (correction of polyunsatulated) fatty acids on the recovery of cardiac function following cold preservation and reperfusion in hyperlipidemic rats. Transplantation 62, 735\u2013742 (1996).","journal-title":"Transplantation"},{"key":"72686_CR59","doi-asserted-by":"publisher","first-page":"D1144","DOI":"10.1093\/nar\/gkr1013","volume":"40","author":"X Wang","year":"2012","unstructured":"Wang, X., Spandidos, A., Wang, H. & Seed, B. PrimerBank: a PCR primer database for quantitative gene expression analysis, 2012 update. Nucleic Acids Res. 40, D1144-1149 (2012).","journal-title":"Nucleic Acids Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-72686-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-72686-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-72686-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T19:09:03Z","timestamp":1670353743000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-72686-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,23]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["72686"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-72686-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,23]]},"assertion":[{"value":"4 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15553"}}