{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:58:41Z","timestamp":1786481921182,"version":"build-2736575974"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to compare the electrophysiology and magnetic resonance neurography (MRN) results of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) subtypes and to explore the progression from atypical CIDP to typical CIDP. We collected the medical records of 45 CIDP patients to analyse the rate of progression from atypical CIDP to typical CIDP subtypes. The cerebrospinal fluid (CSF) protein (p\u2009=\u20090.024) and overall disability sum score (ODSS) (p\u2009=\u20090.000) differed among patients with typical CIDP, distal acquired demyelinating symmetric neuropathy (DADS) and Lewis-Sumner syndrome (LSS). The compound motor action potential (CMAP) of typical CIDP was lower than that of the other subtypes (p\u2009=\u20090.016, p\u2009=\u20090.022 and p\u2009=\u20090.012). The cross-sectional area (CSA) of nerve roots in typical CIDP was significantly thicker than that of nerve roots in DADS and LSS. There were fewer DADS and LSS patients who progressed to typical CIDP than those who progressed to pure motor and pure sensory CIDP (p\u2009=\u20090.000), and the progression from pure motor to typical CIDP required a significantly longer time than the progression from pure sensory to typical CIDP (p\u2009=\u20090.007). Typical CIDP was more severe than the other subtypes not only in terms of clinical and electrophysiology factors but also in terms of MRN factors.<\/jats:p>","DOI":"10.1038\/s41598-020-73104-1","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T10:02:46Z","timestamp":1602064966000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The comparison of MRN, electrophysiology and progression among typical CIDP and atypical CIDP subtypes"],"prefix":"10.1038","volume":"10","author":[{"given":"Yuan","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuansheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuneng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"73104_CR1","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1136\/jnnp-2014-309697","volume":"86","author":"EK Mathey","year":"2015","unstructured":"Mathey, E. K. et al. Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype. J. Neurol. Neurosurg. Psychiatry 86, 973\u2013985 (2015).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"73104_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1529-8027.2010.00245.x","volume":"15","author":"Joint Task Force of the EFNs and the PNS","year":"2010","unstructured":"Joint Task Force of the EFNs and the PNS. European Federation of Neurological Societies\/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological societies and the peripheral Nerve society\u2014First Revision . J. Peripher. Nerv. Syst. 15, 1\u20139 (2010).","journal-title":"J. Peripher. Nerv. Syst."},{"key":"73104_CR3","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1097\/00131402-200306000-00004","volume":"4","author":"KC Gorson","year":"2003","unstructured":"Gorson, K. C. & Ropper, A. H. Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): a review of clinical syndromes and treatment approaches in clinical practice. J. Clin. Neuromuscul. Dis. 4, 174\u2013189 (2003).","journal-title":"J. Clin. Neuromuscul. Dis."},{"key":"73104_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/jns5.12053","volume":"19","author":"E Nobile-Orazio","year":"2014","unstructured":"Nobile-Orazio, E. Chronic inflammatory demyelinating polyradiculoneuropathy and variants: where we are and where we should go. J. Peripher. Nerv. Syst. 19, 2\u201313 (2014).","journal-title":"J. Peripher. Nerv. Syst."},{"key":"73104_CR5","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1136\/jnnp-2014-308452","volume":"86","author":"S Kuwabara","year":"2015","unstructured":"Kuwabara, S. et al. Different electrophysiological profiles and treatment response in \u2019typical\u2019and \u201catypical\u201d chronic inflammatory demyelinating polyneuropathy. J. Neurol. Neurosurg. Psychiatry 86, 1054\u20131059 (2015).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"73104_CR6","first-page":"CD010369","volume":"1","author":"AL Oaklander","year":"2017","unstructured":"Oaklander, A. L. et al. Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews. Cochrane Database Syst. Rev. 1, CD010369 (2017).","journal-title":"Cochrane Database Syst. Rev."},{"key":"73104_CR7","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/S1474-4422(10)70041-7","volume":"9","author":"JM Vallat","year":"2010","unstructured":"Vallat, J. M., Sommer, C. & Magy, L. Chronic inflammatory demyelinating polyradiculoneuropathy: diagnostic and therapeutic challenges for a treatable condition. Lancet Neurol. 9, 402\u2013412 (2010).","journal-title":"Lancet Neurol."},{"key":"73104_CR8","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1136\/jnnp-2018-318714","volume":"90","author":"PE Doneddu","year":"2019","unstructured":"Doneddu, P. E. et al. Italian CIDP Database study group. Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database. J. Neurol. Neurosurg. Psychiatry 90, 125\u2013132 (2019).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"73104_CR9","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.neurol.2014.06.002","volume":"170","author":"R Guimar\u00e3es-Costa","year":"2014","unstructured":"Guimar\u00e3es-Costa, R., Iancu Ferfoglia, R., Viala, K. & L\u00e9ger, J. M. Challenges in the treatment of chronic inflammatory demyelinating polyradiculoneuropathy. Rev. Neurol. (Paris) 170, 595\u2013601 (2014).","journal-title":"Rev. Neurol. (Paris)"},{"key":"73104_CR10","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1097\/WCO.0b013e328363bfa4","volume":"26","author":"F Eftimov","year":"2013","unstructured":"Eftimov, F. & van Schaik, I. Chronic inflammatory demyelinating polyradiculoneuropathy: update on clinical features, phenotypes and treatment options. Curr. Opin. Neurol. 26, 496\u2013502 (2013).","journal-title":"Curr. Opin. Neurol."},{"key":"73104_CR11","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1007\/s00415-015-7770-z","volume":"262","author":"R Gasparotti","year":"2015","unstructured":"Gasparotti, R. et al. Neuroimaging in diagnosis of atypical polyradiculoneuropathies: report of three cases and review of the literature. J. Neurol. 262, 1714\u20131723 (2015).","journal-title":"J. Neurol."},{"key":"73104_CR12","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jns.2015.11.048","volume":"360","author":"P Lozeron","year":"2016","unstructured":"Lozeron, P. et al. Contribution of plexus MRI in the diagnosis of atypical chronic inflammatory demyelinating polyneuropathies. J. Neurol. Sci. 360, 170\u2013175 (2016).","journal-title":"J. Neurol. Sci."},{"key":"73104_CR13","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/mus.21206","volume":"39","author":"YA Rajabally","year":"2009","unstructured":"Rajabally, Y. A., Simpson, B. S., Beri, S., Bankart, J. & Gosalakkal, J. A. Epidemiologic variability of chronic inflammatory demyelinating polyneuropathy with different diagnostic criteria: study of a UK population. Muscle Nerve 39, 432\u2013438 (2009).","journal-title":"Muscle Nerve"},{"key":"73104_CR14","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1111\/j.1468-1331.2010.03312.x","volume":"18","author":"S Larue","year":"2011","unstructured":"Larue, S. et al. Non-anti-MAG DADS neuropathy as a variant of CIDP: clinical, electrophysiological, laboratory features and response to treatment in 10 cases. Eur. J. Neurol. 18, 899\u2013905 (2011).","journal-title":"Eur. J. Neurol."},{"key":"73104_CR15","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1093\/brain\/awh222","volume":"127","author":"K Viala","year":"2004","unstructured":"Viala, K. et al. Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome. Brain 127, 2010\u20132017 (2004).","journal-title":"Brain"},{"key":"73104_CR16","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1007\/s004150170093","volume":"248","author":"M Sabatelli","year":"2001","unstructured":"Sabatelli, M. et al. Pure motor chronic inflammatory demyelinating polyneuropathy. J. Neurol. 248, 772\u2013777 (2001).","journal-title":"J. Neurol."},{"key":"73104_CR17","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1007\/s004150050531","volume":"246","author":"GW van Dijk","year":"1999","unstructured":"van Dijk, G. W., Notermans, N. C., Franssen, H. & Wokke, J. H. Development of weakness in patients with chronic inflammatory demyelinating polyneuropathy and only sensory symptoms at presentation: a long-term follow-up study. J. Neurol. 246, 1134\u20131139 (1999).","journal-title":"J. Neurol."},{"key":"73104_CR18","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1085-9489.2004.09302.x","volume":"9","author":"RL Chin","year":"2004","unstructured":"Chin, R. L. et al. Sensory CIDP presenting as cryptogenic sensory polyneuropathy. J. Peripher. Nerv. Syst. 9, 132\u2013137 (2004).","journal-title":"J. Peripher. Nerv. Syst."},{"key":"73104_CR19","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1093\/brain\/119.3.765","volume":"119","author":"PK Thomas","year":"1996","unstructured":"Thomas, P. K. et al. Focal upper limb demyelinating neuropathy. Brain 119, 765\u2013774 (1996).","journal-title":"Brain"},{"key":"73104_CR20","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1136\/jnnp-2014-308452","volume":"86","author":"S Kuwabara","year":"2015","unstructured":"Kuwabara, S. et al. Different electrophysiological profiles and treatment response in \u2018typical\u2019\u2019 and \u201catypical\u2019\u2019 chronic inflammatory demyelinating polyneuropathy\u201d\u2019. J. Neurol. Neurosurg. Psychiatry 86, 1054\u20131059 (2015).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"73104_CR21","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1159\/000103645","volume":"58","author":"UK Misra","year":"2007","unstructured":"Misra, U. K., Kalita, J. & Yadav, R. K. A comparison of clinically atypical with typical chronic inflammatory demyelinating polyradiculoneuropathy. Eur. Neurol. 58, 100\u2013105 (2007).","journal-title":"Eur. Neurol."},{"key":"73104_CR22","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/mus.25368","volume":"55","author":"T Ishikawa","year":"2017","unstructured":"Ishikawa, T. et al. MR neurography for the evaluation of CIDP. Muscle Nerve 55, 483\u2013489 (2017).","journal-title":"Muscle Nerve"},{"key":"73104_CR23","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1007\/s00415-017-8543-7","volume":"264","author":"M Kronlage","year":"2017","unstructured":"Kronlage, M. et al. Large coverage MR neurography in CIDP: diagnostic accuracy and electrophysiological correlation. J. Neurol 264, 1434\u20131443 (2017).","journal-title":"J. Neurol"},{"key":"73104_CR24","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1589\/jpts.25.1265","volume":"25","author":"JH Kang","year":"2013","unstructured":"Kang, J. H., Kim, H. J. & Lee, E. R. Electrophysiological evaluation of chronic inflammatory demyelinating polyneuropathy and charcot-marie-tooth type 1: dispersion and correlation analysis . J. Phys. Ther. Sci. 25, 1265\u20131268 (2013).","journal-title":"J. Phys. Ther. Sci."},{"key":"73104_CR25","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1136\/jnnp-2019-320741","volume":"90","author":"S Ikeda","year":"2019","unstructured":"Ikeda, S. et al. Clinicopathological characteristics of subtypes of chronic inflammatory demyelinating polyradiculoneuropathy. J. Neurol. Neurosurg. Psychiatry 90, 988\u2013996 (2019).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"73104_CR26","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/S1474-4422(19)30144-9","volume":"18","author":"C Bunschoten","year":"2019","unstructured":"Bunschoten, C., Jacobs, B. C., Van den Bergh, P. Y. K., Cornblath, D. R. & van Doorn, P. A. Progress in diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy. Lancet Neurol. 18, 784\u2013794 (2019).","journal-title":"Lancet Neurol."},{"key":"73104_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s40364-019-0154-2","volume":"7","author":"A Khoo","year":"2019","unstructured":"Khoo, A., Frasca, J. & Schultz, D. Measuring disease activity and predicting response to intravenous immunoglobulin in chronic inflammatory demyelinating polyneuropathy. Biomark Res 7, 3 (2019).","journal-title":"Biomark Res"},{"key":"73104_CR28","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jns.12344","volume":"24","author":"C Bunschoten","year":"2019","unstructured":"Bunschoten, C., Blomkwist-Markens, P. H., Horemans, A., van Doorn, P. A. & Jacobs, B. C. Clinical factors, diagnostic delay, and residual deficits in chronic inflammatory demyelinating polyradiculoneuropathy. J. Peripher. Nerv. Syst. 24, 253\u2013259 (2019).","journal-title":"J. Peripher. Nerv. Syst."},{"issue":"3\u20134","key":"73104_CR29","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1159\/000494291","volume":"52","author":"C Broers Merel","year":"2019","unstructured":"Broers Merel, C. et al. Incidence and prevalence of chronic inflammatory demyelinating polyradiculoneuropathy: a systematic review and meta-analysis. Neuroepidemiology 52(3\u20134), 161\u2013172 (2019).","journal-title":"Neuroepidemiology"},{"issue":"2","key":"73104_CR30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1136\/jnnp-2018-318714","volume":"90","author":"PE Doneddu","year":"2019","unstructured":"Doneddu, P. E. et al. Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database. J. Neurol. Neurosurg. Psychiatry 90(2), 125\u2013132 (2019).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"73104_CR31","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.1007\/s00415-018-9082-6","volume":"265","author":"J Dorst","year":"2018","unstructured":"Dorst, J., Ludolph, A. C., Senel, M. & Tumani, H. Short-term and long-term effects of immunoadsorption in refractory chronic inflammatory demyelinating polyneuropathy: a prospective study in 17 patients. J. Neurol. 265, 2906\u20132915 (2018).","journal-title":"J. Neurol."},{"key":"73104_CR32","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1002\/mus.25967","volume":"57","author":"I Christiansen","year":"2018","unstructured":"Christiansen, I., Markvardsen, L. H. & Jakobsen, J. Comparisons in fluctuation of muscle strength and function in patients with immune-mediated neuropathy treated with intravenous versus subcutaneous immunoglobulin. Muscle Nerve 57, 610\u2013614 (2018).","journal-title":"Muscle Nerve"},{"key":"73104_CR33","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/jca.21546","volume":"32","author":"I Lieker","year":"2017","unstructured":"Lieker, I., Slowinski, T., Harms, L., Hahn, K. & Klehmet, J. A prospective study comparing tryptophan immunoadsorption with therapeutic plasma exchange for the treatment of chronic inflammatory demyelinating polyneuropathy. J. Clin. Apher. 32, 486\u2013493 (2017).","journal-title":"J. Clin. Apher."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-73104-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-73104-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-73104-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T20:45:26Z","timestamp":1670359526000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-73104-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,7]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["73104"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-73104-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,7]]},"assertion":[{"value":"19 November 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16697"}}