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After exclusion, 567 inpatients were included in this study and separated into two groups according to their AST\/ALT ratio on admission. Death was regarded as poor prognosis in this study. Of 567 patients, 200 (35.3%) had AST\/ALT\u2009\u2265\u20091.38. Of the 200 patients, older age (median age 60\u00a0years), myalgia (64 [32%] cases), fatigue (91 [45.5%] cases), some comorbidities and outcomes were significantly different from patients with AST\/ALT\u2009&lt;\u20091.38. They also had worse chest computed tomography (CT) findings, laboratory results and severity scores. Levels of platelet count (OR 0.995, 95% CI [0.992\u20130.998]) and hemoglobin (OR 0.984, 95% CI [0.972\u20130.995]) were independently associated with AST\/ALT\u2009\u2265\u20091.38 on admission. Furthermore, a high AST\/ALT ratio on admission was an independent risk factor for poor prognosis (OR 99.9, 95% CI [2.1\u20134280.5]). In subsequent monitoring, both survivors and non-survivors showed decreased AST\/ALT ratio during hospitalization. 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