{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:22:07Z","timestamp":1793946127522,"version":"4.8.0"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Proyecto de Investigaci\u00f3n en Salud","award":["PI-0140-2018"],"award-info":[{"award-number":["PI-0140-2018"]}]},{"name":"ISCIII Sara Borrell contract","award":["CD19\/0009"],"award-info":[{"award-number":["CD19\/0009"]}]},{"name":"Proyectos de Investigaci\u00f3n en Salud ISCIII","award":["PI16\/01953"],"award-info":[{"award-number":["PI16\/01953"]}]},{"name":"Proyectos de Investigaci\u00f3n en Salud ISCIII","award":["PI16\/01698"],"award-info":[{"award-number":["PI16\/01698"]}]},{"name":"Proyectos de Investigaci\u00f3n en Salud ISCIII","award":["P17\/02026"],"award-info":[{"award-number":["P17\/02026"]}]},{"name":"Proyecto de Investigaci\u00f3n en Drogodependencias","award":["PND2017\/043"],"award-info":[{"award-number":["PND2017\/043"]}]},{"name":"Proyecto de Investigaci\u00f3n en Drogodependencias","award":["PND2019\/040"],"award-info":[{"award-number":["PND2019\/040"]}]},{"name":"Proyecto de Investigaci\u00f3n en Drogodependencias","award":["PND2018\/044"],"award-info":[{"award-number":["PND2018\/044"]}]},{"name":"Miguel Servet contract","award":["CPII\/19\/00022"],"award-info":[{"award-number":["CPII\/19\/00022"]}]},{"name":"ISCIII Miguel Servet contract","award":["CPII17\/00024"],"award-info":[{"award-number":["CPII17\/00024"]}]},{"name":"ISCIII Miguel Servet contract","award":["CPII19\/00031"],"award-info":[{"award-number":["CPII19\/00031"]}]},{"DOI":"10.13039\/501100013816","name":"Departament d'Empresa i Coneixement, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017 SGR 138"],"award-info":[{"award-number":["2017 SGR 138"]}],"id":[{"id":"10.13039\/501100013816","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Redes Tem\u00e1ticas RETICS","award":["RD16\/0017\/001"],"award-info":[{"award-number":["RD16\/0017\/001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lysophosphatidic acid (LPA) species are bioactive lipids participating in neurodevelopmental processes. The aim was to investigate whether the relevant species of LPA were associated with clinical features of alcohol addiction. A total of 55 abstinent alcohol use disorder (AUD) patients were compared with 34 age\/sex\/body mass index-matched controls. Concentrations of total LPA and 16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA species were quantified and correlated with neuroplasticity-associated growth factors including brain derived neurotrophic factor (BDNF), insulin-like growth factor-1 (IGF-1) and IGF-2, and neurotrophin-3 (NT-3). AUD patients showed dysexecutive syndrome (22.4%) and memory impairment (32.6%). Total LPA, 16:0-LPA, 18:0-LPA and 18:1-LPA concentrations, were decreased in the AUD group compared to control group. Total LPA, 16:0-LPA, 18:2-LPA and 20:4-LPA concentrations were decreased in men compared to women. Frontal lobe functions correlated with plasma LPA species. Alcohol-cognitive impairments could be related with the deregulation of the LPA species, especially in 16:0-LPA, 18:1-LPA and 20:4-LPA. Concentrations of BDNF correlated with total LPA, 18:2-LPA and 20:4-LPA species. The relation between LPA species and BDNF is interesting in plasticity and neurogenesis functions, their involvement in AUD might serve as a biomarker of cognitive impairment.<\/jats:p>","DOI":"10.1038\/s41598-020-74155-0","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T10:05:00Z","timestamp":1602583500000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients"],"prefix":"10.1038","volume":"10","author":[{"given":"Nuria","family":"Garc\u00eda-Marchena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves","family":"Pizarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Pav\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Mart\u00ednez-Hu\u00e9lamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Flores-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Requena-Oca\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Araos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Silva-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis J.","family":"Sant\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"de la Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rodr\u00edguez de Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"74155_CR1","doi-asserted-by":"publisher","first-page":"e0116820","DOI":"10.1371\/journal.pone.0116820","volume":"10","author":"HA Whiteford","year":"2015","unstructured":"Whiteford, H. A., Ferrari, A. J., Degenhardt, L., Feigin, V. & Vos, T. The global burden of mental, neurological and substance use disorders: An analysis from the Global Burden of Disease Study 2010. PLoS\u00a0One 10, e0116820. https:\/\/doi.org\/10.1371\/journal.pone.0116820 (2015).","journal-title":"PLoS\u00a0One"},{"key":"74155_CR2","volume-title":"Global Status Report on Alcohol and Health 2018: Executive Summary","author":"WHO","year":"2018","unstructured":"WHO. Global Status Report on Alcohol and Health 2018: Executive Summary (WHO, Geneva, 2018)."},{"key":"74155_CR3","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","volume":"12","author":"A Louvet","year":"2015","unstructured":"Louvet, A. & Mathurin, P. Alcoholic liver disease: Mechanisms of injury and targeted treatment. Nat. Rev. Gastroenterol. Hepatol. 12, 231\u2013242. https:\/\/doi.org\/10.1038\/nrgastro.2015.35 (2015).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"74155_CR4","doi-asserted-by":"publisher","first-page":"509","DOI":"10.2217\/nmt-2016-0030","volume":"6","author":"V Hayes","year":"2016","unstructured":"Hayes, V., Demirkol, A., Ridley, N., Withall, A. & Draper, B. Alcohol-related cognitive impairment: Current trends and future perspectives. Neurodegener. Dis. Manag. 6, 509\u2013523. https:\/\/doi.org\/10.2217\/nmt-2016-0030 (2016).","journal-title":"Neurodegener. Dis. Manag."},{"key":"74155_CR5","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1001\/archpsyc.61.9.891","volume":"61","author":"DS Hasin","year":"2004","unstructured":"Hasin, D. S. & Grant, B. F. The co-occurrence of DSM-IV alcohol abuse in DSM-IV alcohol dependence: Results of the National Epidemiologic Survey on Alcohol and Related Conditions on heterogeneity that differ by population subgroup. Arch. Gen. Psychiatry 61, 891\u2013896. https:\/\/doi.org\/10.1001\/archpsyc.61.9.891 (2004).","journal-title":"Arch. Gen. Psychiatry"},{"key":"74155_CR6","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.1016\/S2468-2667(18)30022-7","volume":"3","author":"M Schwarzinger","year":"2018","unstructured":"Schwarzinger, M. et al. Contribution of alcohol use disorders to the burden of dementia in France 2008\u201313: A nationwide retrospective cohort study. Lancet Public Health 3, e124\u2013e132. https:\/\/doi.org\/10.1016\/S2468-2667(18)30022-7 (2018).","journal-title":"Lancet Public Health"},{"key":"74155_CR7","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1111\/j.1530-0277.2008.00625.x","volume":"32","author":"C Weitlauf","year":"2008","unstructured":"Weitlauf, C. & Woodward, J. J. Ethanol selectively attenuates NMDAR-mediated synaptic transmission in the prefrontal cortex. Alcohol Clin. Exp. Res. 32, 690\u2013698. https:\/\/doi.org\/10.1111\/j.1530-0277.2008.00625.x (2008).","journal-title":"Alcohol Clin. Exp. Res."},{"key":"74155_CR8","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1111\/j.1360-0443.2010.03351.x","volume":"106","author":"JM Boden","year":"2011","unstructured":"Boden, J. M. & Fergusson, D. M. Alcohol and depression. Addiction 106, 906\u2013914. https:\/\/doi.org\/10.1111\/j.1360-0443.2010.03351.x (2011).","journal-title":"Addiction"},{"key":"74155_CR9","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/j.1360-0443.2012.04010.x","volume":"108","author":"S Samet","year":"2013","unstructured":"Samet, S. et al. Effects of independent and substance-induced major depressive disorder on remission and relapse of alcohol, cocaine and heroin dependence. Addiction 108, 115\u2013123. https:\/\/doi.org\/10.1111\/j.1360-0443.2012.04010.x (2013).","journal-title":"Addiction"},{"key":"74155_CR10","doi-asserted-by":"publisher","first-page":"83","DOI":"10.20882\/adicciones.728","volume":"29","author":"N Garcia Marchena","year":"2016","unstructured":"Garcia Marchena, N. et al. Psychiatric comorbidity and plasma levels of 2-acyl-glycerols in outpatient treatment alcohol users. Analysis of gender differences. Adicciones 29, 83\u201396. https:\/\/doi.org\/10.20882\/adicciones.728 (2016).","journal-title":"Adicciones"},{"key":"74155_CR11","doi-asserted-by":"publisher","first-page":"292","DOI":"10.20882\/adicciones.931","volume":"30","author":"A Sanvisens","year":"2018","unstructured":"Sanvisens, A. et al. Patients with alcohol use disorder: Initial results from a prospective multicenter registry in the Spanish Network on Addiction Disorders. CohRTA Study. Adicciones 30, 292\u2013300. https:\/\/doi.org\/10.20882\/adicciones.931 (2018).","journal-title":"Adicciones"},{"key":"74155_CR12","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1097\/01.ALC.0000156131.88125.2A","volume":"29","author":"ME Bates","year":"2005","unstructured":"Bates, M. E., Voelbel, G. T., Buckman, J. F., Labouvie, E. W. & Barry, D. Short-term neuropsychological recovery in clients with substance use disorders. Alcohol Clin. Exp. Res. 29, 367\u2013377 (2005).","journal-title":"Alcohol Clin. Exp. Res."},{"key":"74155_CR13","doi-asserted-by":"publisher","first-page":"256","DOI":"10.2174\/15672026113109990004","volume":"10","author":"S Mukherjee","year":"2013","unstructured":"Mukherjee, S. Alcoholism and its effects on the central nervous system. Curr. Neurovasc. Res. 10, 256\u2013262 (2013).","journal-title":"Curr. Neurovasc. Res."},{"key":"74155_CR14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.encep.2015.12.012","volume":"42","author":"N Cabe","year":"2016","unstructured":"Cabe, N. et al. Cognitive impairments in alcohol dependence: From screening to treatment improvements. Encephale 42, 74\u201381. https:\/\/doi.org\/10.1016\/j.encep.2015.12.012 (2016).","journal-title":"Encephale"},{"key":"74155_CR15","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1111\/j.1530-0277.2007.00418.x","volume":"31","author":"AL Pitel","year":"2007","unstructured":"Pitel, A. L. et al. Genuine episodic memory deficits and executive dysfunctions in alcoholic subjects early in abstinence. Alcohol Clin. Exp. Res. 31, 1169\u20131178. https:\/\/doi.org\/10.1111\/j.1530-0277.2007.00418.x (2007).","journal-title":"Alcohol Clin. Exp. Res."},{"key":"74155_CR16","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s11065-007-9038-6","volume":"17","author":"M Oscar-Berman","year":"2007","unstructured":"Oscar-Berman, M. & Marinkovic, K. Alcohol: Effects on neurobehavioral functions and the brain. Neuropsychol. Rev. 17, 239\u2013257. https:\/\/doi.org\/10.1007\/s11065-007-9038-6 (2007).","journal-title":"Neuropsychol. Rev."},{"key":"74155_CR17","doi-asserted-by":"publisher","first-page":"e0187634","DOI":"10.1371\/journal.pone.0187634","volume":"12","author":"N Garcia-Marchena","year":"2017","unstructured":"Garcia-Marchena, N. et al. Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. PLoS\u00a0One 12, e0187634. https:\/\/doi.org\/10.1371\/journal.pone.0187634 (2017).","journal-title":"PLoS\u00a0One"},{"key":"74155_CR18","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1111\/adb.12668","volume":"24","author":"D Silva-Pena","year":"2019","unstructured":"Silva-Pena, D. et al. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats. Addict. Biol. 24, 1019\u20131033. https:\/\/doi.org\/10.1111\/adb.12668 (2019).","journal-title":"Addict. Biol."},{"key":"74155_CR19","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fnmol.2019.00096","volume":"12","author":"D Silva-Pena","year":"2019","unstructured":"Silva-Pena, D. et al. Oleoylethanolamide modulates BDNF-ERK signaling and neurogenesis in the hippocampi of rats exposed to delta(9)-THC and ethanol binge drinking during adolescence. Front. Mol. Neurosci. 12, 96. https:\/\/doi.org\/10.3389\/fnmol.2019.00096 (2019).","journal-title":"Front. Mol. Neurosci."},{"key":"74155_CR20","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1093\/cercor\/bhm132","volume":"18","author":"G Estivill-Torrus","year":"2008","unstructured":"Estivill-Torrus, G. et al. Absence of LPA1 signaling results in defective cortical development. Cereb. Cortex 18, 938\u2013950. https:\/\/doi.org\/10.1093\/cercor\/bhm132 (2008).","journal-title":"Cereb. Cortex"},{"key":"74155_CR21","doi-asserted-by":"publisher","first-page":"e85348","DOI":"10.1371\/journal.pone.0085348","volume":"9","author":"E Castilla-Ortega","year":"2014","unstructured":"Castilla-Ortega, E. et al. 1-Oleoyl lysophosphatidic acid: A new mediator of emotional behavior in rats. PLoS\u00a0One 9, e85348. https:\/\/doi.org\/10.1371\/journal.pone.0085348 (2014).","journal-title":"PLoS\u00a0One"},{"key":"74155_CR22","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s00702-014-1289-9","volume":"122","author":"M Yamada","year":"2015","unstructured":"Yamada, M. et al. Lysophosphatidic acid induces anxiety-like behavior via its receptors in mice. J. Neural. Transm. (Vienna) 122, 487\u2013494. https:\/\/doi.org\/10.1007\/s00702-014-1289-9 (2015).","journal-title":"J. Neural. Transm. (Vienna)"},{"issue":"Pt 3","key":"74155_CR23","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1042\/bj2910677","volume":"291","author":"T Eichholtz","year":"1993","unstructured":"Eichholtz, T., Jalink, K., Fahrenfort, I. & Moolenaar, W. H. The bioactive phospholipid lysophosphatidic acid is released from activated platelets. Biochem. J. 291(Pt 3), 677\u2013680. https:\/\/doi.org\/10.1042\/bj2910677 (1993).","journal-title":"Biochem. J."},{"key":"74155_CR24","doi-asserted-by":"publisher","first-page":"21197","DOI":"10.1074\/jbc.M201289200","volume":"277","author":"T Sano","year":"2002","unstructured":"Sano, T. et al. Multiple mechanisms linked to platelet activation result in lysophosphatidic acid and sphingosine 1-phosphate generation in blood. J. Biol. Chem. 277, 21197\u201321206. https:\/\/doi.org\/10.1074\/jbc.M201289200 (2002).","journal-title":"J. Biol. Chem."},{"key":"74155_CR25","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1476-5381.2010.00815.x","volume":"161","author":"G Tigyi","year":"2010","unstructured":"Tigyi, G. Aiming drug discovery at lysophosphatidic acid targets. Br. J. Pharmacol. 161, 241\u2013270. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00815.x (2010).","journal-title":"Br. J. Pharmacol."},{"key":"74155_CR26","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1194\/jlr.R046458","volume":"55","author":"YC Yung","year":"2014","unstructured":"Yung, Y. C., Stoddard, N. C. & Chun, J. LPA receptor signaling: Pharmacology, physiology, and pathophysiology. J. Lipid Res. 55, 1192\u20131214 (2014).","journal-title":"J. Lipid Res."},{"key":"74155_CR27","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.bbalip.2012.07.015","volume":"1831","author":"JW Choi","year":"2013","unstructured":"Choi, J. W. & Chun, J. Lysophospholipids and their receptors in the central nervous system. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids 1831, 20\u201332 (2013).","journal-title":"Biochim. Biophys. Acta Mol. Cell. Biol. Lipids"},{"key":"74155_CR28","first-page":"163","volume":"56","author":"ZQ Zheng","year":"2004","unstructured":"Zheng, Z. Q., Fang, X. J. & Qiao, J. T. Dual action of lysophosphatidic acid in cultured cortical neurons: Survival and apoptogenic. Sheng Li Xue Bao 56, 163\u2013171 (2004).","journal-title":"Sheng Li Xue Bao"},{"key":"74155_CR29","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.mcn.2008.07.014","volume":"39","author":"E Matas-Rico","year":"2008","unstructured":"Matas-Rico, E. et al. Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. Mol. Cell. Neurosci. 39, 342\u2013355. https:\/\/doi.org\/10.1016\/j.mcn.2008.07.014 (2008).","journal-title":"Mol. Cell. Neurosci."},{"key":"74155_CR30","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12944-017-0536-0","volume":"16","author":"A Michalczyk","year":"2017","unstructured":"Michalczyk, A., Budkowska, M., Do\u0142\u0119gowska, B., Chlubek, D. & Safranow, K. Lysophosphatidic acid plasma concentrations in healthy subjects: Circadian rhythm and associations with demographic, anthropometric and biochemical parameters. Lipids Health Dis. 16, 140. https:\/\/doi.org\/10.1186\/s12944-017-0536-0 (2017).","journal-title":"Lipids Health Dis."},{"key":"74155_CR31","doi-asserted-by":"publisher","first-page":"e541","DOI":"10.1038\/tp.2015.33","volume":"5","author":"H Mirendil","year":"2015","unstructured":"Mirendil, H. et al. LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage. Transl. Psychiatry 5, e541. https:\/\/doi.org\/10.1038\/tp.2015.33 (2015).","journal-title":"Transl. Psychiatry"},{"key":"74155_CR32","doi-asserted-by":"publisher","first-page":"15444","DOI":"10.1073\/pnas.1106129108","volume":"108","author":"KJ Herr","year":"2011","unstructured":"Herr, K. J., Herr, D. R., Lee, C. W., Noguchi, K. & Chun, J. Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA1) signaling. Proc. Natl. Acad. Sci. USA 108, 15444\u201315449. https:\/\/doi.org\/10.1073\/pnas.1106129108 (2011).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"74155_CR33","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2174\/1570159X15666170710200352","volume":"16","author":"RD Moreno-Fernandez","year":"2018","unstructured":"Moreno-Fernandez, R. D. et al. Stress, depression, resilience and ageing: A role for the LPA-LPA1 pathway. Curr. Neuropharmacol. 16, 271\u2013283. https:\/\/doi.org\/10.2174\/1570159X15666170710200352 (2018).","journal-title":"Curr. Neuropharmacol."},{"key":"74155_CR34","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.neuropharm.2015.12.010","volume":"103","author":"E Castilla-Ortega","year":"2016","unstructured":"Castilla-Ortega, E. et al. Both genetic deletion and pharmacological blockade of lysophosphatidic acid LPA1 receptor results in increased alcohol consumption. Neuropharmacology 103, 92\u2013103. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.12.010 (2016).","journal-title":"Neuropharmacology"},{"key":"74155_CR35","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1258\/acb.2008.007242","volume":"45","author":"S Hosogaya","year":"2008","unstructured":"Hosogaya, S. et al. Measurement of plasma lysophosphatidic acid concentration in healthy subjects: Strong correlation with lysophospholipase D activity. Ann. Clin. Biochem. 45, 364\u2013368. https:\/\/doi.org\/10.1258\/acb.2008.007242 (2008).","journal-title":"Ann. Clin. Biochem."},{"key":"74155_CR36","first-page":"78","volume-title":"DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders, Text Revision","author":"APA","year":"2000","unstructured":"APA. DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders, Text Revision 78\u201385 (American Psychiatric Association, Washington, DC, 2000)."},{"key":"74155_CR37","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1176\/appi.ajp.161.7.1231","volume":"161","author":"M Torrens","year":"2004","unstructured":"Torrens, M., Serrano, D., Astals, M., Perez-Dominguez, G. & Martin-Santos, R. Diagnosing comorbid psychiatric disorders in substance abusers: Validity of the Spanish versions of the Psychiatric Research Interview for Substance and Mental Disorders and the Structured Clinical Interview for DSM-IV. Am. J. Psychiatry 161, 1231\u20131237. https:\/\/doi.org\/10.1176\/appi.ajp.161.7.1231 (2004).","journal-title":"Am. J. Psychiatry"},{"key":"74155_CR38","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1176\/ajp.2006.163.4.689","volume":"163","author":"D Hasin","year":"2006","unstructured":"Hasin, D. et al. Diagnosis of comorbid psychiatric disorders in substance users assessed with the Psychiatric Research Interview for Substance and Mental Disorders for DSM-IV. Am. J. Psychiatry 163, 689\u2013696. https:\/\/doi.org\/10.1176\/ajp.2006.163.4.689 (2006).","journal-title":"Am. J. Psychiatry"},{"key":"74155_CR39","first-page":"605","volume":"36","author":"A Rodriguez del Alamo","year":"2003","unstructured":"Rodriguez del Alamo, A., Catalan Alonso, M. J. & Carrasco Marin, L. FAB: A preliminar Spanish application of the frontal assessment battery to 11 groups of patients. Rev. Neurol. 36, 605\u2013608 (2003).","journal-title":"Rev. Neurol."},{"key":"74155_CR40","first-page":"137","volume":"54","author":"P Lozoya-Delgado","year":"2012","unstructured":"Lozoya-Delgado, P., Ruiz-S\u00e1nchez de Le\u00f3n, J. M. & Pedrero-P\u00e9rez, E. J. Validaci\u00f3n de un cuestionario de quejas cognitivas para adultos j\u00f3venes: Relaci\u00f3n entre las quejas subjetivas de memoria, la sintomatolog\u00eda prefrontal y el estr\u00e9s percibido. Rev. Neurol. 54, 137\u2013150 (2012).","journal-title":"Rev. Neurol."},{"key":"74155_CR41","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1111\/adb.12408","volume":"22","author":"N Garcia-Marchena","year":"2017","unstructured":"Garcia-Marchena, N. et al. Plasma concentrations of oleoylethanolamide and other acylethanolamides are altered in alcohol-dependent patients: Effect of length of abstinence. Addict. Biol. 22, 1366\u20131377. https:\/\/doi.org\/10.1111\/adb.12408 (2017).","journal-title":"Addict. Biol."},{"key":"74155_CR42","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.neuropharm.2018.01.033","volume":"133","author":"L Sanchez-Marin","year":"2018","unstructured":"Sanchez-Marin, L. et al. Systemic blockade of LPA1\/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology 133, 189\u2013201. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.01.033 (2018).","journal-title":"Neuropharmacology"},{"key":"74155_CR43","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1530-0277.2010.01338.x","volume":"35","author":"Z Zhao","year":"2011","unstructured":"Zhao, Z., Yu, M., Crabb, D., Xu, Y. & Liangpunsakul, S. Ethanol-induced alterations in fatty acid-related lipids in serum and tissues in mice. Alcohol. Clin. Exp. Res. 35, 229\u2013234. https:\/\/doi.org\/10.1111\/j.1530-0277.2010.01338.x (2011).","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"74155_CR44","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/2049-9256-1-13","volume":"1","author":"A Teubert","year":"2013","unstructured":"Teubert, A., Thome, J., B\u00fcttner, A., Richter, J. & Irmisch, G. Elevated oleic acid serum concentrations in patients suffering from alcohol dependence. J. Mol. Psychiatry 1, 13 (2013).","journal-title":"J. Mol. Psychiatry"},{"key":"74155_CR45","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1111\/adb.12276","volume":"21","author":"A Bilbao","year":"2016","unstructured":"Bilbao, A. et al. Role of the satiety factor oleoylethanolamide in alcoholism. Addict. Biol. 21, 859\u2013872. https:\/\/doi.org\/10.1111\/adb.12276 (2016).","journal-title":"Addict. Biol."},{"key":"74155_CR46","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1001\/archpsyc.64.7.830","volume":"64","author":"DS Hasin","year":"2007","unstructured":"Hasin, D. S., Stinson, F. S., Ogburn, E. & Grant, B. F. Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch. Gen. Psychiatry 64, 830\u2013842. https:\/\/doi.org\/10.1001\/archpsyc.64.7.830 (2007).","journal-title":"Arch. Gen. Psychiatry"},{"key":"74155_CR47","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.drugalcdep.2018.03.006","volume":"187","author":"TD Saha","year":"2018","unstructured":"Saha, T. D. et al. Concurrent use of alcohol with other drugs and DSM-5 alcohol use disorder comorbid with other drug use disorders: Sociodemographic characteristics, severity, and psychopathology. Drug Alcohol Depend. 187, 261\u2013269. https:\/\/doi.org\/10.1016\/j.drugalcdep.2018.03.006 (2018).","journal-title":"Drug Alcohol Depend."},{"key":"74155_CR48","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.psychres.2018.04.029","volume":"265","author":"EY Kim","year":"2018","unstructured":"Kim, E. Y. et al. Serum lipidomic analysis for the discovery of biomarkers for major depressive disorder in drug-free patients. Psychiatry Res. 265, 174\u2013182. https:\/\/doi.org\/10.1016\/j.psychres.2018.04.029 (2018).","journal-title":"Psychiatry Res."},{"key":"74155_CR49","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0924-977X(02)00130-X","volume":"13","author":"CC Chiu","year":"2003","unstructured":"Chiu, C. C. et al. Polyunsaturated fatty acid deficit in patients with bipolar mania. Eur. Neuropsychopharmacol. 13, 99\u2013103 (2003).","journal-title":"Eur. Neuropsychopharmacol."},{"key":"74155_CR50","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.psychres.2007.08.021","volume":"160","author":"RK McNamara","year":"2008","unstructured":"McNamara, R. K. et al. Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry Res. 160, 285\u2013299. https:\/\/doi.org\/10.1016\/j.psychres.2007.08.021 (2008).","journal-title":"Psychiatry Res."},{"key":"74155_CR51","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s11064-005-2611-6","volume":"30","author":"C Roberts","year":"2005","unstructured":"Roberts, C. et al. Neurochemical changes in LPA1 receptor deficient mice\u2014a putative model of schizophrenia. Neurochem. Res. 30, 371\u2013377. https:\/\/doi.org\/10.1007\/s11064-005-2611-6 (2005).","journal-title":"Neurochem. Res."},{"key":"74155_CR52","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.psychres.2019.01.052","volume":"273","author":"L Gotoh","year":"2019","unstructured":"Gotoh, L. et al. Levels of lysophosphatidic acid in cerebrospinal fluid and plasma of patients with schizophrenia. Psychiatry Res. 273, 331\u2013335. https:\/\/doi.org\/10.1016\/j.psychres.2019.01.052 (2019).","journal-title":"Psychiatry Res."},{"key":"74155_CR53","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-01719-1","author":"DR Herr","year":"2019","unstructured":"Herr, D. R., Chew, W. S., Satish, R. L. & Ong, W. Y. Pleotropic roles of autotaxin in the nervous system present opportunities for the development of novel therapeutics for neurological diseases. Mol. Neurobiol. https:\/\/doi.org\/10.1007\/s12035-019-01719-1 (2019).","journal-title":"Mol. Neurobiol."},{"key":"74155_CR54","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/ijnp\/pyz005","volume":"22","author":"K Itagaki","year":"2019","unstructured":"Itagaki, K. et al. Reduced serum and cerebrospinal fluid levels of autotaxin in major depressive disorder. Int. J. Neuropsychopharmacol. 22, 261\u2013269. https:\/\/doi.org\/10.1093\/ijnp\/pyz005 (2019).","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"74155_CR55","first-page":"127","volume":"33","author":"EV Sullivan","year":"2010","unstructured":"Sullivan, E. V., Harris, R. A. & Pfefferbaum, A. Alcohol\u2019s effects on brain and behavior. Alcohol Res. Health 33, 127\u2013143 (2010).","journal-title":"Alcohol Res. Health"},{"key":"74155_CR56","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/B978-0-444-62619-6.00012-4","volume":"125","author":"M Oscar-Berman","year":"2014","unstructured":"Oscar-Berman, M. et al. Profiles of impaired, spared, and recovered neuropsychologic processes in alcoholism. Handb. Clin. Neurol. 125, 183\u2013210. https:\/\/doi.org\/10.1016\/B978-0-444-62619-6.00012-4 (2014).","journal-title":"Handb. Clin. Neurol."},{"key":"74155_CR57","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fpsyt.2014.00078","volume":"5","author":"F Bernardin","year":"2014","unstructured":"Bernardin, F., Maheut-Bosser, A. & Paille, F. Cognitive impairments in alcohol-dependent subjects. Front. Psychiatry 5, 78. https:\/\/doi.org\/10.3389\/fpsyt.2014.00078 (2014).","journal-title":"Front. Psychiatry"},{"key":"74155_CR58","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1080\/00926230701866125","volume":"34","author":"\u00c1L Montejo","year":"2008","unstructured":"Montejo, \u00c1L. & Rico-Villademoros, F. Psychometric properties of the Psychotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ-SALSEX) in patients with schizophrenia and other psychotic disorders. J. Sex Marital Ther. 34, 227\u2013239 (2008).","journal-title":"J. Sex Marital Ther."},{"key":"74155_CR59","doi-asserted-by":"publisher","first-page":"592","DOI":"10.2174\/1567205013666161201200722","volume":"14","author":"JB Zhang","year":"2017","unstructured":"Zhang, J. B. et al. Plasma phospholipids are associated with mild cognitive impairment in type 2 diabetic patients. Curr. Alzheimer Res. 14, 592\u2013597. https:\/\/doi.org\/10.2174\/1567205013666161201200722 (2017).","journal-title":"Curr. Alzheimer Res."},{"key":"74155_CR60","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1111\/j.1601-183X.2009.00524.x","volume":"8","author":"LJ Santin","year":"2009","unstructured":"Santin, L. J. et al. Behavioral phenotype of maLPA1-null mice: Increased anxiety-like behavior and spatial memory deficits. Genes Brain Behav. 8, 772\u2013784. https:\/\/doi.org\/10.1111\/j.1601-183X.2009.00524.x (2009).","journal-title":"Genes Brain Behav."},{"key":"74155_CR61","doi-asserted-by":"publisher","first-page":"e25522","DOI":"10.1371\/journal.pone.0025522","volume":"6","author":"E Castilla-Ortega","year":"2011","unstructured":"Castilla-Ortega, E. et al. Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA(1) receptor knockout mice. PLoS\u00a0One 6, e25522. https:\/\/doi.org\/10.1371\/journal.pone.0025522 (2011).","journal-title":"PLoS\u00a0One"},{"key":"74155_CR62","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/MOL.0000000000000492","volume":"29","author":"RM Bradley","year":"2018","unstructured":"Bradley, R. M. & Duncan, R. E. The lysophosphatidic acid acyltransferases (acylglycerophosphate acyltransferases) family: One reaction, five enzymes, many roles. Curr. Opin. Lipidol. 29, 110\u2013115. https:\/\/doi.org\/10.1097\/MOL.0000000000000492 (2018).","journal-title":"Curr. Opin. Lipidol."},{"key":"74155_CR63","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3389\/fendo.2017.00182","volume":"8","author":"UN Das","year":"2017","unstructured":"Das, U. N. Is there a role for bioactive lipids in the pathobiology of diabetes mellitus?. Front Endocrinol. (Lausanne) 8, 182. https:\/\/doi.org\/10.3389\/fendo.2017.00182 (2017).","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"74155_CR64","first-page":"993","volume":"48","author":"MV Alfimova","year":"2012","unstructured":"Alfimova, M. V., Lezhe\u012dko, T. V., Gritsenko, I. K. & Golimbet, V. E. Association of the insulin-like growth factor II (IGF2) gene with human cognitive functions. Genetika 48, 993\u2013998 (2012).","journal-title":"Genetika"},{"key":"74155_CR65","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3233\/jad-132183","volume":"41","author":"CJ Green","year":"2014","unstructured":"Green, C. J. et al. The role of IGF-I, IGF-II, and IGFBP-3 in male cognitive aging and dementia risk: The Caerphilly Prospective Study. J. Alzheimer\u2019s Dis. 41, 867\u2013875. https:\/\/doi.org\/10.3233\/jad-132183 (2014).","journal-title":"J. Alzheimer's Dis."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-74155-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-74155-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-74155-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T21:35:46Z","timestamp":1670362546000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-74155-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,13]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["74155"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-74155-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,13]]},"assertion":[{"value":"3 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17163"}}