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Although disease progression in the mouse does not perfectly model the human disease, it shares many pathological features. Early characterizations of the model reported severe pathology through early adulthood followed by disease stabilization. As a result, research in the\n                    <jats:italic>mdx<\/jats:italic>\n                    mouse has largely focused on early adulthood. The overarching goal of this study is to improve the understanding of the\n                    <jats:italic>mdx<\/jats:italic>\n                    mouse model by tracking pathological features of the disease throughout life. We performed a thorough characterization of myofiber pathology in\n                    <jats:italic>mdx<\/jats:italic>\n                    mice from 2\u00a0weeks to 2\u00a0years of age. We report that individual\n                    <jats:italic>mdx<\/jats:italic>\n                    muscle fibers undergo progressive hypertrophy that continues through the lifespan. Despite massive hypertrophy on the myofiber level, we report no hypertrophy on the muscle level. These seemingly contradictory findings are explained by previously underappreciated myofiber loss in\n                    <jats:italic>mdx<\/jats:italic>\n                    mice. We conclude that due to myofiber loss, in combination with the progressive nature of other pathological features, aged\n                    <jats:italic>mdx<\/jats:italic>\n                    muscle tissue provides reliable benchmarks for disease progression that may be valuable in testing the efficacy of therapeutics for Duchenne muscular dystrophy.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-74192-9","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T06:04:52Z","timestamp":1602655492000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Lifetime analysis of mdx skeletal muscle reveals a progressive pathology that leads to myofiber loss"],"prefix":"10.1038","volume":"10","author":[{"given":"Ryan T.","family":"Massopust","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young il","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Pritchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van-Khoa M.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan A.","family":"McCreedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley J.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,14]]},"reference":[{"key":"74192_CR1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0960-8966(91)90039-U","volume":"1","author":"AE Emery","year":"1991","unstructured":"Emery, A. 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