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We investigated phosphate clearance, removal and serum level, and factors associated with phosphate control in patients undergoing continuous ambulatory (CAPD), continuous cyclic (CCPD) and automated (APD) peritoneal dialysis (PD). In 154 prevalent PD patients (mean age 53.2\u2009\u00b1\u200917.6\u00a0year, 59% men, 47% anuric), 196\u00a0daily collections of urine and 368 collections of dialysate were evaluated in terms of renal, peritoneal and total (renal plus peritoneal) phosphorus removal (g\/week), phosphate and creatinine clearances (L\/week) and urea KT\/V. Dialytic removal of phosphorus was lower in APD (1.34\u2009\u00b1\u20090.62\u00a0g\/week) than in CAPD (1.89\u2009\u00b1\u20090.73\u00a0g\/week) and CCPD (1.91\u2009\u00b1\u20090.63\u00a0g\/week) patients; concomitantly, serum phosphorus was higher in APD than in CAPD (5.55\u2009\u00b1\u20091.61 vs. 4.84\u2009\u00b1\u20091.23\u00a0mg\/dL; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Peritoneal and total phosphate clearances correlated with peritoneal (rho\u2009=\u20090.93) and total (rho\u2009=\u20090.85) creatinine clearances (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but less with peritoneal and total urea KT\/V (rho\u2009=\u20090.60 and rho\u2009=\u20090.65, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Phosphate removal, clearance and serum levels differed between PD modalities. CAPD\u00a0was associated with higher peritoneal removal and lower serum level of phosphate than APD.<\/jats:p>","DOI":"10.1038\/s41598-020-74412-2","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T10:07:55Z","timestamp":1602756475000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Phosphate clearance in peritoneal dialysis"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8741-7930","authenticated-orcid":false,"given":"Malgorzata","family":"Debowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Waniewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Lindholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"key":"74412_CR1","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1007\/s40620-014-0142-4","volume":"28","author":"A Galassi","year":"2015","unstructured":"Galassi, A., Cupisti, A., Santoro, A. & Cozzolino, M. 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BL is employed by Baxter Healthcare. Baxter Novum is the result of grant from Baxter Healthcare to Karolinska Institutet. None of the other authors declare any competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17504"}}