{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:06:18Z","timestamp":1791237978466,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005076","name":"Agricultural Research Development Agency","doi-asserted-by":"crossref","award":["CRP6205030090"],"award-info":[{"award-number":["CRP6205030090"]}],"id":[{"id":"10.13039\/501100005076","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is mainly caused because of inappropriate immune responses in the epidermis. Rice (<jats:italic>Oryza sativa<\/jats:italic> L.: SRNC05053-6-2) consists of anthocyanin, which exhibits strong antioxidative and anti-inflammatory properties. This study aimed to evaluate the role of this black-coloured rice crude extract in alleviating the symptoms of psoriasis using human psoriatic artificial skin and an imiquimod-induced rat psoriasis model. Psoriasis-related genes, cytokines and chemokines were examined; in addition, the antioxidative and anti-inflammatory properties and the immunohistopathological features of this condition were studied. The results showed that the rice extract reduced the severity of psoriasis by (1) decreasing the epidermal thickness, acanthosis, hyperkeratosis, epidermal inflammation and degree of apoptosis induction via caspase-3, (2) increasing the expression levels of anti-inflammatory cytokines (IL-10 and TGF-\u03b2), (3) reducing the levels of pro-inflammatory cytokines (IL-6, IL-8, IL-20, IL-22 and TNF-\u03b1), chemokines (CCL-20) and anti-microbial peptides (psoriasin and \u03b2-defensin), (4) enhancing the antioxidative property (Nrf-2), (5) downregulating the levels of psoriasis-associated genes (<jats:italic>psoriasin<\/jats:italic>, <jats:italic>\u03b2-defensin<\/jats:italic>, <jats:italic>koebnerisin 15L<\/jats:italic> and <jats:italic>koebnerisin 15S<\/jats:italic>) and (6) upregulating the levels of psoriasis-improving genes (<jats:italic>caspase-14<\/jats:italic>, <jats:italic>involucrin<\/jats:italic> and <jats:italic>filaggrin<\/jats:italic>). Thus, the extract appears to exert therapeutic effects on psoriasis through its antioxidative and immunomodulatory properties.<\/jats:p>","DOI":"10.1038\/s41598-020-74634-4","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T10:09:45Z","timestamp":1603102185000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Evaluating the effect of rice (Oryza sativa L.: SRNC05053-6-2) crude extract on psoriasis using in vitro and in vivo models"],"prefix":"10.1038","volume":"10","author":[{"given":"Sumate","family":"Ampawong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchana","family":"Kengkoom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Passanesh","family":"Sukphopetch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornanong","family":"Aramwit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Watcharamat","family":"Muangkaew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapanee","family":"Kanjanapruthipong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theerapong","family":"Buaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"74634_CR1","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1159\/000447535","volume":"232","author":"MB Abdel-Naser","year":"2016","unstructured":"Abdel-Naser, M. B. et al. Increased activity and number of epidermal melanocytes in lesional psoriatic skin. Dermatology 232, 425\u2013430. https:\/\/doi.org\/10.1159\/000447535 (2016).","journal-title":"Dermatology"},{"key":"74634_CR2","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1084\/jem.20151093","volume":"212","author":"A Arakawa","year":"2015","unstructured":"Arakawa, A. et al. Melanocyte antigen triggers autoimmunity in human psoriasis. J. Exp. Med. 212, 2203\u20132212. https:\/\/doi.org\/10.1084\/jem.20151093 (2015).","journal-title":"J. Exp. Med."},{"key":"74634_CR3","doi-asserted-by":"publisher","first-page":"2186","DOI":"10.1084\/jem.21213insight3","volume":"212","author":"JG Krueger","year":"2015","unstructured":"Krueger, J. G. An autoimmune \u201cattack\u201d on melanocytes triggers psoriasis and cellular hyperplasia. J. Exp. Med. 212, 2186. https:\/\/doi.org\/10.1084\/jem.21213insight3 (2015).","journal-title":"J. Exp. Med."},{"key":"74634_CR4","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.jid.2017.05.023","volume":"137","author":"JC Prinz","year":"2017","unstructured":"Prinz, J. C. Melanocytes: target cells of an HLA-C*06:02-restricted autoimmune response in psoriasis. J. Investig. Dermatol 137, 2053\u20132058. https:\/\/doi.org\/10.1016\/j.jid.2017.05.023 (2017).","journal-title":"J. Investig. Dermatol"},{"key":"74634_CR5","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/pcmr.12470","volume":"29","author":"JP Strassner","year":"2016","unstructured":"Strassner, J. P., Rashighi, M. & Harris, J. E. Melanocytes in psoriasis: convicted culprit or bullied bystander?. Pigment Cell Melanoma Res. 29, 261\u2013263. https:\/\/doi.org\/10.1111\/pcmr.12470 (2016).","journal-title":"Pigment Cell Melanoma Res."},{"key":"74634_CR6","first-page":"36","volume":"9","author":"BI Ferreira","year":"2016","unstructured":"Ferreira, B. I., Abreu, J. L., Reis, J. P. & Figueiredo, A. M. Psoriasis and associated psychiatric disorders: a systematic review on etiopathogenesis and clinical correlation. J. Clin. Aesthet. Dermatol. 9, 36\u201343 (2016).","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"74634_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/CS20100163","volume":"120","author":"G Monteleone","year":"2011","unstructured":"Monteleone, G., Pallone, F., MacDonald, T. T., Chimenti, S. & Costanzo, A. Psoriasis: from pathogenesis to novel therapeutic approaches. Clin. Sci. (London) 120, 1\u201311. https:\/\/doi.org\/10.1042\/CS20100163 (2011).","journal-title":"Clin. Sci. (London)"},{"key":"74634_CR8","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1111\/ijfs.13674","volume":"53","author":"S Surin","year":"2018","unstructured":"Surin, S., Surayot, U., Seesuriyachan, P., You, S. & Phimolsiripol, Y. Antioxidant and immunomodulatory activities of sulphated polysaccharides from purple glutinous rice bran (Oryza sativa L.). Int. J. Food Sci. Technol. 53, 994\u20131004 (2018).","journal-title":"Int. J. Food Sci. Technol."},{"key":"74634_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/foods7100159","volume":"7","author":"L Thiranusornkij","year":"2018","unstructured":"Thiranusornkij, L., Thamnarathip, P., Chandrachai, A., Kuakpetoon, D. & Adisakwattana, S. Physicochemical properties of Hom Nil (Oryza sativa) rice flour as gluten free ingredient in bread. Foods 7, 1\u201313. https:\/\/doi.org\/10.3390\/foods7100159 (2018).","journal-title":"Foods"},{"key":"74634_CR10","first-page":"8","volume":"8","author":"A Saiyot","year":"2017","unstructured":"Saiyot, A. et al. Mali Nil Surin (Mali Dam 2), a non glutinous rice variety. Thai Rice Res. J. 8, 8\u201325 (2017).","journal-title":"Thai Rice Res. J."},{"key":"74634_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu11092169","volume":"11","author":"L Vollono","year":"2019","unstructured":"Vollono, L. et al. Potential of curcumin in skin disorders. Nutrients 11, 1\u201325. https:\/\/doi.org\/10.3390\/nu11092169 (2019).","journal-title":"Nutrients"},{"key":"74634_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/pharmaceutics11120639","volume":"11","author":"SA Yousef","year":"2019","unstructured":"Yousef, S. A. et al. Mechanistic evaluation of enhanced curcumin delivery through human skin in vitro from optimised nanoemulsion formulations fabricated with different penetration enhancers. Pharmaceutics 11, 1\u201320. https:\/\/doi.org\/10.3390\/pharmaceutics11120639 (2019).","journal-title":"Pharmaceutics"},{"key":"74634_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09546634.2019.1675854","volume":"30","author":"T Sheriff","year":"2019","unstructured":"Sheriff, T., Lin, M. J., Dubin, D. & Khorasani, H. The potential role of cannabinoids in dermatology. J. Dermatol. Treat. 30, 1\u20137. https:\/\/doi.org\/10.1080\/09546634.2019.1675854 (2019).","journal-title":"J. Dermatol. Treat."},{"key":"74634_CR14","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.bbrc.2013.12.128","volume":"443","author":"HR Austin","year":"2014","unstructured":"Austin, H. R. et al. Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin. Biochem. Biophys. Res. Commun. 443, 1275\u20131279. https:\/\/doi.org\/10.1016\/j.bbrc.2013.12.128 (2014).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"74634_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1089\/ars.2016.6769","volume":"26","author":"JC Chamcheu","year":"2017","unstructured":"Chamcheu, J. C. et al. Dual inhibition of PI3K\/Akt and mTOR by the dietary antioxidant, delphinidin, ameliorates psoriatic features in vitro and in an imiquimod-induced psoriasis-like disease in mice. Antioxid. Redox Signal 26, 49\u201369. https:\/\/doi.org\/10.1089\/ars.2016.6769 (2017).","journal-title":"Antioxid. Redox Signal"},{"key":"74634_CR16","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/exd.12140","volume":"22","author":"JC Chamcheu","year":"2013","unstructured":"Chamcheu, J. C. et al. Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: studies in submerged and three-dimensional epidermal equivalent models. Exp. Dermatol. 22, 342\u2013348. https:\/\/doi.org\/10.1111\/exd.12140 (2013).","journal-title":"Exp. Dermatol."},{"key":"74634_CR17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1159\/000368445","volume":"28","author":"JC Chamcheu","year":"2015","unstructured":"Chamcheu, J. C. et al. Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis. Skin Pharmacol. Physiol. 28, 177\u2013188. https:\/\/doi.org\/10.1159\/000368445 (2015).","journal-title":"Skin Pharmacol. Physiol."},{"key":"74634_CR18","doi-asserted-by":"publisher","first-page":"H253","DOI":"10.1111\/j.1750-3841.2009.01327.x","volume":"74","author":"SJ Han","year":"2009","unstructured":"Han, S. J. et al. Metabolism of cyanidin-3-O-beta-d-glucoside isolated from black colored rice and its antiscratching behavioral effect in mice. J. Food Sci. 74, H253-258. https:\/\/doi.org\/10.1111\/j.1750-3841.2009.01327.x (2009).","journal-title":"J. Food Sci."},{"key":"74634_CR19","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1111\/bjd.13513","volume":"172","author":"HC Pal","year":"2015","unstructured":"Pal, H. C. et al. Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation. Br. J. Dermatol. 172, 354\u2013364. https:\/\/doi.org\/10.1111\/bjd.13513 (2015).","journal-title":"Br. J. Dermatol."},{"key":"74634_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox9060486","volume":"9","author":"A Westfall","year":"2020","unstructured":"Westfall, A., Sigurdson, G. T., Rodriguez-Saona, L. E. & Giusti, M. M. Ex Vivo and in vivo assessment of the penetration of topically applied anthocyanins utilizing ATR-FTIR\/PLS regression models and HPLC-PDA-MS. Antioxidants (Basel) 9, 1\u201314. https:\/\/doi.org\/10.3390\/antiox9060486 (2020).","journal-title":"Antioxidants (Basel)"},{"key":"74634_CR21","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s00403-013-1390-1","volume":"305","author":"E Hoss","year":"2013","unstructured":"Hoss, E. et al. Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin. Arch. Dermatol. Res. 305, 867\u2013878. https:\/\/doi.org\/10.1007\/s00403-013-1390-1 (2013).","journal-title":"Arch. Dermatol. Res."},{"key":"74634_CR22","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s00726-010-0666-4","volume":"41","author":"R Wolf","year":"2011","unstructured":"Wolf, R., Ruzicka, T. & Yuspa, S. H. Novel S100A7 (psoriasin)\/S100A15 (koebnerisin) subfamily: highly homologous but distinct in regulation and function. Amino Acids 41, 789\u2013796. https:\/\/doi.org\/10.1007\/s00726-010-0666-4 (2011).","journal-title":"Amino Acids"},{"key":"74634_CR23","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s12272-017-0955-5","volume":"40","author":"YJ Lee","year":"2017","unstructured":"Lee, Y. J. et al. Pro-oxidant status and Nrf2 levels in psoriasis vulgaris skin tissues and dimethyl fumarate-treated HaCaT cells. Arch. Pharm. Res. 40, 1105\u20131116. https:\/\/doi.org\/10.1007\/s12272-017-0955-5 (2017).","journal-title":"Arch. Pharm. Res."},{"key":"74634_CR24","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/jid.2009.252","volume":"130","author":"G Han","year":"2010","unstructured":"Han, G. et al. A role for TGFbeta signaling in the pathogenesis of psoriasis. J. Investig. Dermatol. 130, 371\u2013377. https:\/\/doi.org\/10.1038\/jid.2009.252 (2010).","journal-title":"J. Investig. Dermatol."},{"key":"74634_CR25","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3109\/13880209.2013.771376","volume":"51","author":"JM Hwang","year":"2013","unstructured":"Hwang, J. M., Kuo, H. C., Lin, C. T. & Kao, E. S. Inhibitory effect of liposome-encapsulated anthocyanin on melanogenesis in human melanocytes. Pharm. Biol. 51, 941\u2013947. https:\/\/doi.org\/10.3109\/13880209.2013.771376 (2013).","journal-title":"Pharm. Biol."},{"key":"74634_CR26","first-page":"63","volume":"70","author":"A Westfall","year":"2019","unstructured":"Westfall, A., Sigurdson, G. T. & Giusti, M. M. Antioxidant, UV protection, and antiphotoaging properties of anthocyanin-pigmented lipstick formulations. J. Cosmet. Sci. 70, 63\u201376 (2019).","journal-title":"J. Cosmet. Sci."},{"key":"74634_CR27","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/BF00417276","volume":"264","author":"G Stuttgen","year":"1979","unstructured":"Stuttgen, G., Brinkmann-Raestrupp, I., Haller, L., Kentsch, V. & Schalla, W. Melanin granula distribution and phagocytosis in psoriasis vulgaris after PUVA therapy. Arch. Dermatol. Res. 264, 29\u201335. https:\/\/doi.org\/10.1007\/BF00417276 (1979).","journal-title":"Arch. Dermatol. Res."},{"key":"74634_CR28","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s40659-018-0204-5","volume":"51","author":"P Aramwit","year":"2018","unstructured":"Aramwit, P., Luplertlop, N., Kanjanapruthipong, T. & Ampawong, S. Effect of urea-extracted sericin on melanogenesis: potential applications in post-inflammatory hyperpigmentation. Biol. Res. 51, 54. https:\/\/doi.org\/10.1186\/s40659-018-0204-5 (2018).","journal-title":"Biol. Res."},{"key":"74634_CR29","doi-asserted-by":"publisher","first-page":"e0137890","DOI":"10.1371\/journal.pone.0137890","volume":"10","author":"YK Lin","year":"2015","unstructured":"Lin, Y. K., Yang, S. H., Chen, C. C., Kao, H. C. & Fang, J. Y. Using imiquimod-induced psoriasis-like skin as a model to measure the skin penetration of anti-psoriatic drugs. PLoS ONE 10, e0137890. https:\/\/doi.org\/10.1371\/journal.pone.0137890 (2015).","journal-title":"PLoS ONE"},{"key":"74634_CR30","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.14670\/HH-11-733","volume":"31","author":"S Ampawong","year":"2016","unstructured":"Ampawong, S. & Aramwit, P. Tolerogenic responses of CD206+, CD83+, FOXP3+, and CTLA-4 to sericin\/polyvinyl alcohol\/glycerin scaffolds relevant to IL-33 and HSP60 activity. Histol. Histopathol. 31, 1011\u20131027. https:\/\/doi.org\/10.14670\/HH-11-733 (2016).","journal-title":"Histol. Histopathol."},{"key":"74634_CR31","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1186\/s12936-015-0922-x","volume":"14","author":"S Ampawong","year":"2015","unstructured":"Ampawong, S. et al. A potential role for interleukin-33 and gamma-epithelium sodium channel in the pathogenesis of human malaria associated lung injury. Malar. J. 14, 389. https:\/\/doi.org\/10.1186\/s12936-015-0922-x (2015).","journal-title":"Malar. J."},{"key":"74634_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.yexcr.2017.07.001","volume":"358","author":"S Ampawong","year":"2017","unstructured":"Ampawong, S., Isarangkul, D. & Aramwit, P. Sericin improves heart and liver mitochondrial architecture in hypercholesterolaemic rats and maintains pancreatic and adrenal cell biosynthesis. Exp Cell Res 358, 301\u2013314. https:\/\/doi.org\/10.1016\/j.yexcr.2017.07.001 (2017).","journal-title":"Exp Cell Res"},{"key":"74634_CR33","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1177\/1535370216681553","volume":"242","author":"S Ampawong","year":"2017","unstructured":"Ampawong, S., Isarangkul, D. & Aramwit, P. Sericin ameliorated dysmorphic mitochondria in high-cholesterol diet\/streptozotocin rat by antioxidative property. Exp Biol Med (Maywood) 242, 411\u2013421. https:\/\/doi.org\/10.1177\/1535370216681553 (2017).","journal-title":"Exp Biol Med (Maywood)"},{"key":"74634_CR34","doi-asserted-by":"publisher","first-page":"14943","DOI":"10.1038\/s41598-018-33372-4","volume":"8","author":"S Ampawong","year":"2018","unstructured":"Ampawong, S., Isarangkul, D., Reamtong, O. & Aramwit, P. Adaptive effect of sericin on hepatic mitochondrial conformation through its regulation of apoptosis, autophagy and energy maintenance: a proteomics approach. Sci Rep 8, 14943. https:\/\/doi.org\/10.1038\/s41598-018-33372-4 (2018).","journal-title":"Sci Rep"},{"key":"74634_CR35","doi-asserted-by":"publisher","first-page":"6076571","DOI":"10.1155\/2019\/6076571","volume":"2019","author":"S Ampawong","year":"2019","unstructured":"Ampawong, S. & Luplertlop, N. Experimental scedosporiosis induces cerebral oedema associated with abscess regarding Aquaporin-4 and Nrf-2 depletions. Biomed Res Int 2019, 6076571. https:\/\/doi.org\/10.1155\/2019\/6076571 (2019).","journal-title":"Biomed Res Int"},{"key":"74634_CR36","first-page":"639","volume":"6","author":"K Kengkoom","year":"2013","unstructured":"Kengkoom, K. et al. Effects on high cholesterol-fed to liver, retina, hippocampus, and Harderian gland in Goto-Kakizaki rat. Int. J. Clin. Exp. Pathol. 6, 639\u2013649 (2013).","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"74634_CR37","doi-asserted-by":"publisher","first-page":"5871","DOI":"10.3892\/etm.2017.5270","volume":"14","author":"K Kengkoom","year":"2017","unstructured":"Kengkoom, K., Tirawanchai, N. N., Angkhasirisap, W. & Ampawong, S. Omeprazole preserves the RER in chief cells and enhances re-epithelialization of parietal cells with SOD and AQP-4 up-regulation in ethanol-induced gastritis rats. Exp. Ther. Med. 14, 5871\u20135880. https:\/\/doi.org\/10.3892\/etm.2017.5270 (2017).","journal-title":"Exp. Ther. Med."},{"key":"74634_CR38","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1177\/1535370218757458","volume":"243","author":"S Maknitikul","year":"2018","unstructured":"Maknitikul, S., Luplertlop, N., Chaisri, U., Maneerat, Y. & Ampawong, S. Featured article: immunomodulatory effect of hemozoin on pneumocyte apoptosis via CARD9 pathway, a possibly retarding pulmonary resolution. Exp. Biol. Med. (Maywood) 243, 395\u2013407. https:\/\/doi.org\/10.1177\/1535370218757458 (2018).","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"74634_CR39","doi-asserted-by":"publisher","first-page":"e0181674","DOI":"10.1371\/journal.pone.0181674","volume":"12","author":"S Maknitikul","year":"2017","unstructured":"Maknitikul, S., Luplertlop, N., Grau, G. E. R. & Ampawong, S. Dysregulation of pulmonary endothelial protein C receptor and thrombomodulin in severe falciparum malaria-associated ARDS relevant to hemozoin. PLoS ONE 12, e0181674. https:\/\/doi.org\/10.1371\/journal.pone.0181674 (2017).","journal-title":"PLoS ONE"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-74634-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-74634-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-74634-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T21:42:00Z","timestamp":1670362920000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-74634-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["74634"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-74634-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"assertion":[{"value":"12 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17618"}}