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High-molecular weight HA (HMW-HA) is an important component of the endothelial wall and has anti-inflammatory and antioxidant properties. Under inflammation or hypoxia, HMW-HA is degraded by hyaluronidases, such as HYAL-1 resulting in pro-inflammatory low-molecular weight fragments. Obstructive sleep apnoea (OSA) is characterised by intermittent hypoxia and systemic inflammation. Our aim was to evaluate circulating HMW-HA and HYAL-1 in OSA. We recruited 68 patients with OSA and 40 control volunteers. After full-night sleep study blood samples were taken for HMW-HA and HYAL-1 measurements. HYAL-1 levels were significantly higher in patients with OSA compared to controls (0.59\/0.31\u20130.88\/ng\/mL vs. 0.31\/0.31\u20130.58\/ng\/mL; p\u2009=\u20090.005) after adjustment for gender, age, BMI and smoking. There was a trend for reduced HMW-HA concentrations in OSA (31.63\/18.11\u201359.25\/ng\/mL vs. 46.83\/25.41\u201389.95\/ng\/mL; p\u2009=\u20090.068). Significant correlation was detected between circulating HMW-HA and apnoea-hypopnoea-index (r\u2009=\u2009\u2212 0.195, p\u2009=\u20090.043), HYAL-1 and apnoea-hypopnoea-index (r\u2009=\u20090.30, p\u2009&lt;\u20090.01) as well as oxygen desaturation index (r\u2009=\u20090.26, p\u2009&lt;\u20090.01). Our results suggest that chronic hypoxia is associated with increased plasma HYAL-1 concentration and accelerated HMW-HA degradation. Altered hyaluronan metabolism may be involved in the inflammatory cascade potentially leading to endothelial dysfunction in OSA.<\/jats:p>","DOI":"10.1038\/s41598-020-74769-4","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T06:02:41Z","timestamp":1604988161000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The role of hyaluronic acid and hyaluronidase-1 in obstructive sleep apnoea"],"prefix":"10.1038","volume":"10","author":[{"given":"Martina","family":"Meszaros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Kis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laszlo","family":"Kunos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam Domonkos","family":"Tarnoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Laszlo","family":"Tarnoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsofia","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Bikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"74769_CR1","doi-asserted-by":"publisher","unstructured":"Bikov, A. et al. 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