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We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B<jats:sub>12<\/jats:sub>, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age\u2009\u00b1\u2009standard deviation: 56.0\u2009\u00b1\u20098.9\u00a0years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41\u20133.96) in men and 1.86 (95% CI 1.11\u20133.11) in women, as compared with the lowest group (<jats:italic>P<\/jats:italic> for trend\u2009=\u20090.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (<jats:italic>P<\/jats:italic> for trend\u2009=\u20090.099 and 0.703, respectively). Plasma vitamin B<jats:sub>12<\/jats:sub> was positively associated with hypertension only in women (<jats:italic>P<\/jats:italic> for trend\u2009=\u20090.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B<jats:sub>12<\/jats:sub>.<\/jats:p>","DOI":"10.1038\/s41598-020-75267-3","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T11:24:39Z","timestamp":1603884279000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional 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