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We investigated how ventricular expansion (width of the temporal horns [TH], callosal angle [CA], and Evans\u2019 index [EI]) related to symptom severity in suspected iNPH. Participants (n\u2009=\u2009168; 74.9\u00a0years\u2009\u00b1\u2009SD 6.7; 55% females) from the general population underwent neurological examination, computed tomography, and neuropsychological testing. Multiple linear regression analysis revealed that wide TH was independently associated with all examined iNPH symptoms (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) except for fine-motor performance, whereas a narrow CA only was associated to specific motor and cognitive functions (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). TH and EI correlated significantly with incontinence (r<jats:sub>s<\/jats:sub>0.17 and r<jats:sub>s<\/jats:sub>0.16;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In conclusion, wide TH was significantly associated with most iNPH-symptoms. This finding potentially reflects the complex nature of the hippocampus, however further studies are needed to demonstrate functional connectivity.<\/jats:p>","DOI":"10.1038\/s41598-020-75381-2","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T10:06:00Z","timestamp":1603447560000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Wide temporal horns are associated with cognitive dysfunction, as well as impaired gait and incontinence"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5857-9287","authenticated-orcid":false,"given":"Otto","family":"Lilja-Lund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4686-0941","authenticated-orcid":false,"given":"Karin","family":"Kockum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9803-7271","authenticated-orcid":false,"given":"Per","family":"Hellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-6501","authenticated-orcid":false,"given":"Lars","family":"S\u00f6derstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-1746","authenticated-orcid":false,"given":"Lars","family":"Nyberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-8354","authenticated-orcid":false,"given":"Katarina","family":"Laurell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"75381_CR1","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/NEJM196507152730301","volume":"273","author":"RD Adams","year":"1965","unstructured":"Adams, R. 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