{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T13:53:47Z","timestamp":1771682027762,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"This work was supported by a grant provided by the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea","award":["2017-672"],"award-info":[{"award-number":["2017-672"]}]},{"name":"This work was supported by a grant provided by the Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea","award":["2018-672"],"award-info":[{"award-number":["2018-672"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Breast-conserving surgery (BCS) is performed in patients with ductal carcinoma in situ (DCIS) because of the small size of the tumor. It is essential to know the quantitative extent of the tumor before performing this precise partial resection surgery. A three-dimensional printed (3DP) breast surgical guide (BSG) was developed using information obtained from supine magnetic resonance imaging (MRI) and 3D printing technology and it was used for treating patients with breast cancer. Here, we report our experience with the application of the BSG for patients with DCIS. Patients with breast cancer who underwent BCS from July 2017 to February 2019 were included in this study. The patients underwent partial resection with a supine-MRI based 3DP-BSG. A total of 102 BCS using 3DP-BSG were conducted, and 11 cases were DCIS. The patients\u2019 median age was 56\u00a0years (range, 38\u201369\u00a0years). The mean tumor diameter was 1.3\u2009\u00b1\u20090.9\u00a0cm. The median surgical time was 70\u00a0min (range, 40\u201388\u00a0min). All patients had tumor-free resection margins. The median distance from the tumor to the margin was 11\u00a0mm (range, 2\u201335\u00a0mm). Direct demarcation of the tumor extent in the breast and a pain-free procedure are the advantages of using 3DP-BSG in patients with DCIS.<\/jats:p><jats:p>Trial registration: Clinical Research Information Service (CRIS) Identifier Number: KCT0002375, KCT0003043.<\/jats:p>","DOI":"10.1038\/s41598-020-75398-7","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T11:24:39Z","timestamp":1603884279000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Magnetic resonance imaging based 3-dimensional printed breast surgical guide for breast-conserving surgery in ductal carcinoma in situ: a clinical trial"],"prefix":"10.1038","volume":"10","clinical-trial-number":[{"clinical-trial-number":"kct0002375","registry":"10.18810\/cris"},{"clinical-trial-number":"kct0003043","registry":"10.18810\/cris"}],"author":[{"given":"Zhen-Yu","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Alzuhair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heejeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il Yong","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jisun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae Byul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Ho","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyungyub","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hak Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Beom","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei Hyun","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namkug","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BeomSeok","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"75398_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4048\/jbc.2017.20.1.1","volume":"20","author":"EH Park","year":"2017","unstructured":"Park, E. 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Radioguided occult lesion localization (ROLL) versus wire-guided lumpectomy for non-palpable breast lesions: a randomized prospective evaluation. J. Surg. Oncol. 97, 108\u2013111 (2008).","journal-title":"J. Surg. Oncol."},{"key":"75398_CR9","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s10434-001-0711-3","volume":"8","author":"RJ Gray","year":"2001","unstructured":"Gray, R. J. et al. Randomized prospective evaluation of a novel technique for biopsy or lumpectomy of nonpalpable breast lesions: radioactive seed versus wire localization. Ann. Surg. Oncol. 8, 711\u2013715 (2001).","journal-title":"Ann. Surg. Oncol."},{"key":"75398_CR10","doi-asserted-by":"publisher","first-page":"872","DOI":"10.2214\/AJR.14.12743","volume":"204","author":"D Sharek","year":"2015","unstructured":"Sharek, D. et al. Radioactive seed localization versus wire localization for lumpectomies: a comparison of outcomes. AJR Am. J. Roentgenol. 204, 872\u2013877 (2015).","journal-title":"AJR Am. J. 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Zhen-Yu Wu received consulting fees from ANYMEDi, Inc. Aisha Alzuhair, Heejeong Kim, Jong Won Lee, Il Yong Chung, Jisun Kim, Sae Byul Lee, Byung Ho Son, Gyungyub Gong, Hak Hee Kim, Joon Beom Seo, and Sei Hyun Ahn declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18534"}}