{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:02:17Z","timestamp":1793754137704,"version":"4.6.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the reported benefits of intravenous iron therapy (IVIT) for correcting iron deficiency anemia (IDA) before any major surgery and the evidence thereof, perioperative allogenic blood transfusion (ABT) practice is still considered as the only viable option by some clinicians worldwide. As ABT increases the likelihood of infections, cardiac complications, longer hospital stays and mortality among the patients, the practice of ABT should only be reserved for critical cases (Hb level\u2009&lt;\u20097\u00a0g\/dl). Timely iron studies and iron replenishment (oral\/IV) of prospective surgical patients could help decrease the ABT practice, and prove beneficial from both the clinical and economic standpoint. Evidence based patient blood management guidelines should be developed and standardized for use by clinicians worldwide. These guidelines should include specific instructions on timely assessment of surgical patients for correction of their IDA by either oral iron supplementation, if time permits, or by using IVIT such as ferric carboxymaltose (FCM) in emergency surgeries and in patients with functional ID. This study was conducted to explore the clinical benefits of the timely administration of IV-FCM in iron-deficient preoperative patients during 2017\u20132018 and compare the results thereof with that of the ABT. Based on the IDA treatment plan of 2953 patients, 11.14% cases were administered IV FCM (Group 1), 11.58% cases received ABT (Group 2), while the remaining 77.27% of anemic cases received neither ABT nor IV FCM (Group 3). The results indicate that the IV FCM administration reduces the need for ABT and thus minimizes its associated side effects. The findings of our study concur with the favorable outcomes reported by the other similar studies.<\/jats:p>","DOI":"10.1038\/s41598-020-75535-2","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T11:03:40Z","timestamp":1603796620000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Intravenous iron infusion as an alternative to minimize blood transfusion in peri-operative patients"],"prefix":"10.1038","volume":"10","author":[{"given":"Alin","family":"Ionescu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinav","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilima Rajpal","family":"Kundnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Mih\u0103ilescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad Lauren\u021biu","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ovidiu","family":"Bedreag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorel","family":"S\u0103ndesc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Raluca","family":"Dinu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai Alexandru","family":"S\u0103ndesc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolae","family":"Albulescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103zvan Gabriel","family":"Dr\u0103goi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"issue":"4","key":"75535_CR1","first-page":"241","volume":"11","author":"K Jimenez","year":"2015","unstructured":"Jimenez, K., Kulnigg-Dabsch, S. & Gasche, C. Management of iron deficiency anemia. Gastroenterol. Hepatol. 11(4), 241\u2013250 (2015).","journal-title":"Gastroenterol. Hepatol."},{"issue":"5","key":"75535_CR2","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1182\/blood-2013-06-508325","volume":"123","author":"NJ Kassebaum","year":"2014","unstructured":"Kassebaum, N. J. et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood 123(5), 615\u2013624 (2014).","journal-title":"Blood"},{"issue":"4","key":"75535_CR3","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1017\/S1368980008002401","volume":"12","author":"E McLean","year":"2009","unstructured":"McLean, E. et al. Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993\u20132005. Public Health Nutr. 12(4), 444\u2013454 (2009).","journal-title":"Public Health Nutr."},{"issue":"6","key":"75535_CR4","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1136\/gut.2010.214312","volume":"61","author":"R Evstatiev","year":"2012","unstructured":"Evstatiev, R. & Gasche, C. Iron sensing and signalling. Gut 61(6), 933\u2013952 (2012).","journal-title":"Gut"},{"issue":"10","key":"75535_CR5","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1056\/NEJMra041809","volume":"352","author":"G Weiss","year":"2005","unstructured":"Weiss, G. & Goodnough, L. T. Anemia of chronic disease. N. Engl. J. Med. 352(10), 1011\u20131023 (2005).","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"75535_CR6","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/j.1365-2796.2010.02251.x","volume":"268","author":"A Khalafallah","year":"2010","unstructured":"Khalafallah, A. et al. A prospective randomized, controlled trial of intravenous versus oral iron for moderate iron deficiency anaemia of pregnancy. J. Intern. Med. 268(3), 286\u2013295 (2010).","journal-title":"J. Intern. Med."},{"issue":"7","key":"75535_CR7","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1080\/00365520902839667","volume":"44","author":"S Lindgren","year":"2009","unstructured":"Lindgren, S. et al. Intravenous iron sucrose is superior to oral iron sulphate for correcting anaemia and restoring iron stores in IBD patients: A randomized, controlled, evaluator-blind, multicentre study. Scand. J. Gastroenterol. 44(7), 838\u2013845 (2009).","journal-title":"Scand. J. Gastroenterol."},{"issue":"11","key":"75535_CR8","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1111\/j.1572-0241.2005.00250.x","volume":"100","author":"O Schroder","year":"2005","unstructured":"Schroder, O. et al. Intravenous iron sucrose versus oral iron supplementation for the treatment of iron deficiency anemia in patients with inflammatory bowel disease: a randomized, controlled, open-label, multicenter study. Am. J. Gastroenterol. 100(11), 2503\u20132509 (2005).","journal-title":"Am. J. Gastroenterol."},{"issue":"3","key":"75535_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.cgh.2012.10.013","volume":"11","author":"R Evstatiev","year":"2013","unstructured":"Evstatiev, R. et al. Ferric carboxymaltose prevents recurrence of anemia in patients with inflammatory bowel disease. Clin. Gastroenterol. Hepatol. 11(3), 269\u2013277 (2013).","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"5","key":"75535_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/bmjopen-2012-000998","volume":"2","author":"AA Khalafallah","year":"2012","unstructured":"Khalafallah, A. A. et al. Three-year follow-up of a randomised clinical trial of intravenous versus oral iron for anaemia in pregnancy. BMJ Open 2(5), 1 (2012).","journal-title":"BMJ Open"},{"issue":"1","key":"75535_CR11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.7326\/0003-4819-157-1-201206190-00429","volume":"157","author":"JL Carson","year":"2012","unstructured":"Carson, J. L. et al. Red blood cell transfusion: a clinical practice guideline from the AABB*. Ann. Intern. Med. 157(1), 49\u201358 (2012).","journal-title":"Ann. Intern. Med."},{"issue":"6","key":"75535_CR12","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1056\/NEJM199902113400601","volume":"340","author":"PC Hebert","year":"1999","unstructured":"Hebert, P. C. et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care: Transfusion requirements in critical care investigators, Canadian Critical Care Trials Group. N. Engl. J. Med. 340(6), 409\u2013417 (1999).","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"75535_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1211801","volume":"368","author":"C Villanueva","year":"2013","unstructured":"Villanueva, C. et al. Transfusion strategies for acute upper gastrointestinal bleeding. N. Engl. J. Med. 368(1), 11\u201321 (2013).","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"75535_CR14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/SLA.0000000000001646","volume":"264","author":"B Froessler","year":"2016","unstructured":"Froessler, B. et al. The important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial. Ann. Surg. 264(1), 41\u201346 (2016).","journal-title":"Ann. Surg."},{"issue":"5","key":"75535_CR15","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1111\/j.1479-828X.2012.01478.x","volume":"52","author":"RM Browning","year":"2012","unstructured":"Browning, R. M. et al. Preoperative anaemia is common in patients undergoing major gynaecological surgery and is associated with a fivefold increased risk of transfusion. Aust. N. Z. J. Obstet. Gynaecol. 52(5), 455\u2013459 (2012).","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"issue":"2","key":"75535_CR16","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/sj.bjc.6604165","volume":"98","author":"W Hamilton","year":"2008","unstructured":"Hamilton, W. et al. The importance of anaemia in diagnosing colorectal cancer: a case-control study using electronic primary care records. Br. J. Cancer 98(2), 323\u2013327 (2008).","journal-title":"Br. J. Cancer"},{"issue":"3","key":"75535_CR17","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1097\/ALN.0b013e31819878d3","volume":"110","author":"WS Beattie","year":"2009","unstructured":"Beattie, W. S. et al. Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study. Anesthesiology 110(3), 574\u2013581 (2009).","journal-title":"Anesthesiology"},{"key":"75535_CR18","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1097\/SLA.0b013e318288e957","volume":"258","author":"PK Gupta","year":"2013","unstructured":"Gupta, P. K. et al. Preoperative anemia is an independent predictor of postoperative mortality and adverse cardiac events in elderly patients undergoing elective vascular operations. Ann. Surg. 258, 1096\u20131102 (2013).","journal-title":"Ann. Surg."},{"issue":"2","key":"75535_CR19","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/SLA.0b013e31825b35d5","volume":"256","author":"AG Acheson","year":"2012","unstructured":"Acheson, A. G., Brookes, M. J. & Spahn, D. R. Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: a systematic review and meta-analysis. Ann. Surg. 256(2), 235\u2013244 (2012).","journal-title":"Ann. Surg."},{"issue":"1","key":"75535_CR20","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/01.MIB.0000191670.04605.e7","volume":"12","author":"LT Pizzi","year":"2006","unstructured":"Pizzi, L. T. et al. Impact of chronic conditions on quality of life in patients with inflammatory bowel disease. Inflamm. Bowel. Dis. 12(1), 47\u201352 (2006).","journal-title":"Inflamm. Bowel. Dis."},{"issue":"4","key":"75535_CR21","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.jclinepi.2011.11.004","volume":"65","author":"J Sanders","year":"2012","unstructured":"Sanders, J. et al. The development of a postoperative morbidity score to assess total morbidity burden after cardiac surgery. J. Clin. Epidemiol. 65(4), 423\u2013433 (2012).","journal-title":"J. Clin. Epidemiol."},{"issue":"1","key":"75535_CR22","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1001\/archsurg.2011.790","volume":"147","author":"VA Ferraris","year":"2012","unstructured":"Ferraris, V. A. et al. Surgical outcomes and transfusion of minimal amounts of blood in the operating room. Arch. Surg. 147(1), 49\u201355 (2012).","journal-title":"Arch. Surg."},{"key":"75535_CR23","unstructured":"15, 2015, N.B.A.P.b.m.g.M.P.A.a.h.w.n.g.a.g.m.p.-v.a.p.A.A."},{"issue":"4","key":"75535_CR24","first-page":"585","volume":"11","author":"SR Leal-Noval","year":"2013","unstructured":"Leal-Noval, S. R. et al. Spanish Consensus Statement on alternatives to allogeneic blood transfusion: the 2013 update of the \u201cSeville Document\u201d. Blood Transfus. 11(4), 585\u2013610 (2013).","journal-title":"Blood Transfus."},{"issue":"10 Pt 2","key":"75535_CR25","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1111\/trf.12687","volume":"54","author":"H Gombotz","year":"2014","unstructured":"Gombotz, H. et al. The second Austrian benchmark study for blood use in elective surgery: results and practice change. Transfusion 54(10 Pt 2), 2646\u20132657 (2014).","journal-title":"Transfusion"},{"key":"75535_CR26","first-page":"1","volume":"1","author":"M Munoz","year":"2015","unstructured":"Munoz, M. et al. Pre-operative anaemia: prevalence, consequences and approaches to management. Blood Transfus. 1, 1\u201310 (2015).","journal-title":"Blood Transfus."},{"issue":"5","key":"75535_CR27","first-page":"960","volume":"38","author":"B Froessler","year":"2010","unstructured":"Froessler, B. & Papendorf, D. Intravenous iron sucrose: an effective and attractive modality for perioperative anaemia management. Anaesth. Intensive Care 38(5), 960\u2013962 (2010).","journal-title":"Anaesth. Intensive Care"},{"issue":"1","key":"75535_CR28","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.transci.2013.12.006","volume":"50","author":"A Shander","year":"2014","unstructured":"Shander, A. Preoperative anemia and its management. Transfus. Apheres. Sci. 50(1), 13\u201315 (2014).","journal-title":"Transfus. Apheres. Sci."},{"key":"75535_CR29","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1423-0410.2007.01014.x","volume":"94","author":"M Munoz","year":"2008","unstructured":"Munoz, M. et al. Efficacy and safety of intravenous iron therapy as an alternative\/adjunct to allogeneic blood transfusion. Vox Sang. 94, 172\u2013183 (2008).","journal-title":"Vox Sang."},{"issue":"1","key":"75535_CR30","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/s00595-004-2888-0","volume":"35","author":"M Okuyama","year":"2005","unstructured":"Okuyama, M. et al. Preoperative iron supplementation and intraoperative transfusion during colorectal cancer surgery. Surg. Today 35(1), 36\u201340 (2005).","journal-title":"Surg. Today"},{"key":"75535_CR31","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1002\/ibd.20285","volume":"13","author":"C Gasche","year":"2007","unstructured":"Gasche, C. et al. Guidelines on the diagnosis and management of iron deficiency and anemia in inflammatory bowel diseases. Inflamm. Bowel Dis. 13, 1545\u20131553 (2007).","journal-title":"Inflamm. Bowel Dis."},{"issue":"3","key":"75535_CR32","first-page":"296","volume":"12","author":"M Auerbach","year":"2014","unstructured":"Auerbach, M. & Macdougall, I. C. Safety of intravenous iron formulations: facts and folklore. Blood Transfus. 12(3), 296\u2013300 (2014).","journal-title":"Blood Transfus."},{"issue":"1","key":"75535_CR33","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.bpa.2013.02.002","volume":"27","author":"JP Isbister","year":"2013","unstructured":"Isbister, J. P. The three-pillar matrix of patient blood management: an overview. Best Pract. Res. Clin. Anaesthesiol. 27(1), 69\u201384 (2013).","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"issue":"2","key":"75535_CR34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.tmrv.2010.11.001","volume":"25","author":"JP Isbister","year":"2011","unstructured":"Isbister, J. P. et al. Adverse blood transfusion outcomes: establishing causation. Transfus. Med. Rev. 25(2), 89\u2013101 (2011).","journal-title":"Transfus. Med. Rev."},{"issue":"8","key":"75535_CR35","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1001\/archinte.165.8.845","volume":"165","author":"A Tinmouth","year":"2005","unstructured":"Tinmouth, A. et al. Reducing the amount of blood transfused: a systematic review of behavioral interventions to change physicians\u2019 transfusion practices. Arch. Intern. Med. 165(8), 845\u2013852 (2005).","journal-title":"Arch. Intern. Med."},{"issue":"5","key":"75535_CR36","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1046\/j.1537-2995.1985.25586020109.x","volume":"25","author":"TS Kickler","year":"1985","unstructured":"Kickler, T. S. et al. Estimation of transfused red cell survival using an enzyme-linked antiglobulin test. Transfusion 25(5), 401\u2013405 (1985).","journal-title":"Transfusion"},{"issue":"8","key":"75535_CR37","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.3748\/wjg.v20.i8.1972","volume":"20","author":"M Mu\u00f1oz","year":"2014","unstructured":"Mu\u00f1oz, M. et al. Perioperative anemia management in colorectal cancer patients: a pragmatic approach. World J. Gastroenterol. 20(8), 1972\u20131985 (2014).","journal-title":"World J. Gastroenterol."},{"issue":"11","key":"75535_CR38","doi-asserted-by":"publisher","first-page":"e504","DOI":"10.1016\/S2352-3026(16)30152-1","volume":"3","author":"MF Eisenga","year":"2016","unstructured":"Eisenga, M. F., Bakker, S. J. & Gaillard, C. A. Definition of functional iron deficiency and intravenous iron supplementation. Lancet. Haematol. 3(11), e504 (2016).","journal-title":"Lancet. Haematol."},{"issue":"7","key":"75535_CR39","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1111\/j.1537-2995.2011.03495.x","volume":"52","author":"LT Goodnough","year":"2012","unstructured":"Goodnough, L. T. Iron deficiency syndromes and iron-restricted erythropoiesis (CME). Transfusion 52(7), 1584\u20131592 (2012).","journal-title":"Transfusion"},{"issue":"23","key":"75535_CR40","doi-asserted-by":"publisher","first-page":"4754","DOI":"10.1182\/blood-2010-05-286260","volume":"116","author":"LT Goodnough","year":"2010","unstructured":"Goodnough, L. T., Nemeth, E. & Ganz, T. Detection, evaluation, and management of iron-restricted erythropoiesis. Blood 116(23), 4754\u20134761 (2010).","journal-title":"Blood"},{"issue":"11","key":"75535_CR41","doi-asserted-by":"publisher","first-page":"e504","DOI":"10.1016\/S2352-3026(16)30151-X","volume":"3","author":"AA Khalafallah","year":"2016","unstructured":"Khalafallah, A. A. Definition of functional iron deficiency and intravenous iron supplementation: author\u2019s reply. Lancet. Haematol. 3(11), e504\u2013e505 (2016).","journal-title":"Lancet. Haematol."},{"issue":"5","key":"75535_CR42","doi-asserted-by":"publisher","first-page":"e0215427","DOI":"10.1371\/journal.pone.0215427","volume":"14","author":"HW Shin","year":"2019","unstructured":"Shin, H. W. et al. Efficacy of perioperative intravenous iron therapy for transfusion in orthopedic surgery: a systematic review and meta-analysis. PLoS ONE 14(5), e0215427\u2013e0215427 (2019).","journal-title":"PLoS ONE"},{"issue":"6","key":"75535_CR43","doi-asserted-by":"publisher","first-page":"461","DOI":"10.5581\/1516-8484.20110123","volume":"33","author":"RD Can\u00e7ado","year":"2011","unstructured":"Can\u00e7ado, R. D. & Mu\u00f1oz, M. Intravenous iron therapy: how far have we come?. Rev. Bras. Hematol. Hemoter. 33(6), 461\u2013469 (2011).","journal-title":"Rev. Bras. Hematol. Hemoter."},{"issue":"26","key":"75535_CR44","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1056\/NEJM199912233412607","volume":"341","author":"NC Andrews","year":"1999","unstructured":"Andrews, N. C. Disorders of iron metabolism. N. Engl. J. Med. 341(26), 1986\u20131995 (1999).","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"75535_CR45","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1111\/j.1365-3148.2005.00629.x","volume":"16","author":"M Munoz","year":"2006","unstructured":"Munoz, M. et al. Role of parenteral iron in transfusion requirements after total hip replacement: a pilot study. Transfus. Med. 16(2), 137\u2013142 (2006).","journal-title":"Transfus. Med."},{"issue":"21","key":"75535_CR46","doi-asserted-by":"publisher","first-page":"5025","DOI":"10.1111\/bph.13268","volume":"172","author":"J Szebeni","year":"2015","unstructured":"Szebeni, J. et al. Hypersensitivity to intravenous iron: classification, terminology, mechanisms and management. Br. J. Pharmacol. 172(21), 5025\u20135036 (2015).","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"75535_CR47","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1080\/14740338.2018.1400009","volume":"17","author":"M Munoz","year":"2018","unstructured":"Munoz, M., Gomez-Ramirez, S. & Bhandari, S. The safety of available treatment options for iron-deficiency anemia. Expert Opin. Drug Saf. 17(2), 149\u2013159 (2018).","journal-title":"Expert Opin. Drug Saf."},{"issue":"1","key":"75535_CR48","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mayocp.2014.10.007","volume":"90","author":"T Avni","year":"2015","unstructured":"Avni, T. et al. The safety of intravenous iron preparations: systematic review and meta-analysis. Mayo Clin. Proc. 90(1), 12\u201323 (2015).","journal-title":"Mayo Clin. Proc."},{"key":"75535_CR49","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.2147\/DDDT.S55499","volume":"8","author":"JE Toblli","year":"2014","unstructured":"Toblli, J. E. & Angerosa, M. Optimizing iron delivery in the management of anemia: patient considerations and the role of ferric carboxymaltose. Drug Des. Dev. Ther. 8, 2475\u20132491 (2014).","journal-title":"Drug Des. Dev. Ther."},{"issue":"5","key":"75535_CR50","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/bja\/aen054","volume":"100","author":"P Beris","year":"2008","unstructured":"Beris, P. et al. Perioperative anaemia management: consensus statement on the role of intravenous iron. Br. J. Anaesth. 100(5), 599\u2013604 (2008).","journal-title":"Br. J. Anaesth."},{"key":"75535_CR51","unstructured":"Froessler, B., Foerster, D., Hardt, T., Rueger, A., Connolly M. Treatment cost effects of perioperative anemia treatment with ferric carboxymaltose. in 18th Annual Symposium. 2017. Florence, Italy: Network for the Advancement of Patient Blood Management, Haemostasis and Thrombosis."},{"issue":"5","key":"75535_CR52","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1007\/s00104-012-2464-x","volume":"84","author":"C Honemann","year":"2013","unstructured":"Honemann, C. et al. Costs of delivering allogenic blood in hospitals. Chirurg 84(5), 426\u2013432 (2013).","journal-title":"Chirurg"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-75535-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-75535-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-75535-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T22:25:04Z","timestamp":1670365504000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-75535-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["75535"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-75535-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"assertion":[{"value":"1 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18403"}}