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We aim to compare the long-term efficacy and safety of fractionated stereotactic radiotherapy (FSRT) with SSRS in the treatment of grade I meningioma. A total of 228 patients with 245 tumors treated with radiosurgery between March 2006 and June 2017were retrospectively evaluated. Of these, 147 (64.5%) patients were treated with SSRS. The remaining 81 patients (35.5%) were treated with a fractionated technique. Protocols to treat meningioma were classified as 12\u201316\u00a0Gy per fraction for SSRS and 7\u00a0Gy\/fraction\/day for three consecutive days to reach a total dose of 21\u00a0Gy for FSRT.\u00a0In univariate and multivariate analyses, tumor volume was found to be associated with local control rate (hazard ratio\u2009=\u20094.98, p\u2009=\u20090.025). The difference in actuarial local control rate (LCR) between the SSRS and FSRT groups after propensity score matching (PSM) was not statistically significant during the 2-year (96.86% versus 100.00%, respectively; p\u2009=\u20090.175), 5-year (94.76% versus 97.56%, respectively; p\u2009=\u20090.373), and 10-year (74.40% versus 91.46%, respectively; p\u2009=\u20090.204) follow-up period.\u00a0FSRT and SSRS were equally well-tolerated and effective for the treatment of intracranial benign meningioma during the10-year follow-up period.<\/jats:p>","DOI":"10.1038\/s41598-020-75559-8","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T07:24:39Z","timestamp":1603869879000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study"],"prefix":"10.1038","volume":"10","author":[{"given":"Sheng-Han","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chieh","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Nen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Cheng","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien-Chih","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Jui","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko-Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Ching","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"75559_CR1","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1227\/01.NEU.0000188281.91351.B9","volume":"57","author":"EB Claus","year":"2005","unstructured":"Claus, E. 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