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Since HLA-G is associated with the modulation of the immune response, we hypothesized that variability at the 3\u2032 untraslated region (3\u2032UTR) of the gene could be implicated on the predisposition to CMV-R. We evaluated whether\n                    <jats:italic>HLA-G<\/jats:italic>\n                    3\u2032UTR influences CMV-R development in Brazilian AIDS patients. Peripheral blood DNA was obtained from two groups of patients: (1) AIDS exhibiting CMV-R (n\u2009=\u200940) and (2) AIDS without CMV-R (n\u2009=\u2009147).\n                    <jats:italic>HLA-G<\/jats:italic>\n                    3\u2032UTR typing was performed using sequencing analysis. Allele, genotype and haplotype frequencies were evaluated using Fisher\u2019s exact test accompanied by the calculation of the odds ratio and its 95% confidence interval (95% CI). The etiologic (EF) and preventive fractions were also estimated. Compared to AIDS patients without CMV-R, AIDS patients with CMV-R showed increased frequencies of the: (1) +\u20093001T allele, (2) the +\u20093001C\/T genotype and (3) the UTR-17 (InsTTCCGTGACG) haplotype (EFs\u2009=\u20090.02\u20130.04). The UTR-3 (DelTCCGCGACG) haplotype was associated with protection against CMV-R development. Although the risk for developing CMR-V at the population level was relatively low (EF), the identification of\n                    <jats:italic>HLA-G<\/jats:italic>\n                    3\u2032UTR variation sites may help to further evaluate the role of post-transcriptional factors that may contribute to the existent immunosuppresion caused by HIV per se.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-75639-9","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T07:02:54Z","timestamp":1603954974000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Variability at the 3\u2032 untranslated region of the HLA-G gene: a study on patients with AIDS and cytomegalovirus retinochoroiditis"],"prefix":"10.1038","volume":"10","author":[{"given":"Luciana de Morais","family":"Vicente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick C.","family":"Castelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de Lourdes","family":"Veronese Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neifi Hassan Saloum","family":"Deghaide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Teixeira","family":"Mendes-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o M.","family":"Furtado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Antonio","family":"Donadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"75639_CR1","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1167\/iovs.18-26517.PubMed","volume":"60","author":"GN Holland","year":"2019","unstructured":"Holland, G. 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