{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:04:18Z","timestamp":1792649058793,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"crossref","award":["569575"],"award-info":[{"award-number":["569575"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hippocampal atrophy and cognitive decline are common sequelae of many neurodegenerative disorders, including stroke. To determine whether cognitive decline can be ameliorated by exercise-induced neurogenesis, C57BL\/6 mice in which a unilateral hippocampal injury had been induced by injecting the vasoconstrictor endothelin-1 into their right hippocampus, were run voluntarily for 21\u00a0days on a running-wheel. We found the severe deficits in spatial learning, as detected by active place-avoidance task, following injury were almost completely restored in animals that ran whereas those that did not run showed no improvement. We show the increase in neurogenesis found in both the injured and contralateral hippocampi following running was responsible for the restoration of learning since bilateral ablation of newborn doublecortin (DCX)-positive neurons abrogated the cognitive improvement, whereas\u00a0unilateral ablations of DCX-positive neurons did not prevent recovery, demonstrating that elevated neurogenesis in either the damaged or intact hippocampus is sufficient to reverse hippocampal injury-induced deficits.<\/jats:p>","DOI":"10.1038\/s41598-020-76176-1","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T11:02:46Z","timestamp":1604660566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Exercise reverses learning deficits induced by hippocampal injury by promoting neurogenesis"],"prefix":"10.1038","volume":"10","author":[{"given":"Lavinia N.","family":"Codd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Blackmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Vukovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry F.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"76176_CR1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1001\/jama.2015.6968","volume":"314","author":"DA Levine","year":"2015","unstructured":"Levine, D. A. et al. Trajectory of cognitive decline after incident stroke. JAMA-J. Am. Med. Assoc. 314, 41\u201351. https:\/\/doi.org\/10.1001\/jama.2015.6968 (2015).","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"76176_CR2","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1212\/WNL.0b013e31823ed0cc","volume":"78","author":"S Blum","year":"2012","unstructured":"Blum, S. et al. Memory after silent stroke: Hippocampus and infarcts both matter. Neurology 78, 38\u201346. https:\/\/doi.org\/10.1212\/WNL.0b013e31823ed0cc (2012).","journal-title":"Neurology"},{"key":"76176_CR3","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1002\/hbm.22782","volume":"36","author":"P Schaapsmeerders","year":"2015","unstructured":"Schaapsmeerders, P. et al. Ipsilateral hippocampal atrophy is associated with long-term memory dysfunction after ischemic stroke in young adults. Hum. Brain Mapp. 36, 2432\u20132442. https:\/\/doi.org\/10.1002\/hbm.22782 (2015).","journal-title":"Hum. Brain Mapp."},{"key":"76176_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/ana.22386","volume":"70","author":"MJ Xie","year":"2011","unstructured":"Xie, M. J. et al. Glial gap junctional communication involvement in hippocampal damage after middle cerebral artery occlusion. Ann. Neurol. 70, 121\u2013132. https:\/\/doi.org\/10.1002\/ana.22386 (2011).","journal-title":"Ann. Neurol."},{"key":"76176_CR5","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1016\/j.neurobiolaging.2014.02.017","volume":"35","author":"S Bolognin","year":"2014","unstructured":"Bolognin, S., Buffelli, M., Puolivali, J. & Iqbal, K. Rescue of cognitive-aging by administration of a neurogenic and\/or neurotrophic compound. Neurobiol. Aging 35, 2134\u20132146. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.02.017 (2014).","journal-title":"Neurobiol. Aging"},{"key":"76176_CR6","doi-asserted-by":"publisher","first-page":"13532","DOI":"10.1523\/jneurosci.3362-09.2009","volume":"29","author":"W Deng","year":"2009","unstructured":"Deng, W., Saxe, M. D., Gallina, I. S. & Gage, F. H. Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain. J. Neurosci. 29, 13532\u201313542. https:\/\/doi.org\/10.1523\/jneurosci.3362-09.2009 (2009).","journal-title":"J. Neurosci."},{"key":"76176_CR7","doi-asserted-by":"publisher","first-page":"14385","DOI":"10.1073\/pnas.2334169100","volume":"100","author":"E Drapeau","year":"2003","unstructured":"Drapeau, E. et al. Spatial memory performances of aged rats in the water maze predict levels of hippocampal neurogenesis. Proc. Natl. Acad. Sci. U.S.A. 100, 14385\u201314390. https:\/\/doi.org\/10.1073\/pnas.2334169100 (2003).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"76176_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001959","author":"D Dupret","year":"2008","unstructured":"Dupret, D. et al. Spatial relational memory requires hippocampal adult neurogenesis. PLoS ONE https:\/\/doi.org\/10.1371\/journal.pone.0001959 (2008).","journal-title":"PLoS ONE"},{"key":"76176_CR9","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1038\/nn.2185","volume":"11","author":"I Imayoshi","year":"2008","unstructured":"Imayoshi, I. et al. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat. Neurosci. 11, 1153\u20131161. https:\/\/doi.org\/10.1038\/nn.2185 (2008).","journal-title":"Nat. Neurosci."},{"key":"76176_CR10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1101\/lm.1172609","volume":"16","author":"S Jessberger","year":"2009","unstructured":"Jessberger, S. et al. Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats. Learn. Mem. 16, 147\u2013154. https:\/\/doi.org\/10.1101\/lm.1172609 (2009).","journal-title":"Learn. Mem."},{"key":"76176_CR11","doi-asserted-by":"publisher","first-page":"8680","DOI":"10.1523\/jneurosci.1731-05.2005","volume":"25","author":"H van Praag","year":"2005","unstructured":"van Praag, H., Shubert, T., Zhao, C. M. & Gage, F. H. Exercise enhances learning and hippocampal neurogenesis in aged mice. J. Neurosci. 25, 8680\u20138685. https:\/\/doi.org\/10.1523\/jneurosci.1731-05.2005 (2005).","journal-title":"J. Neurosci."},{"key":"76176_CR12","doi-asserted-by":"publisher","first-page":"6603","DOI":"10.1523\/jneurosci.3064-12.2013","volume":"33","author":"J Vukovic","year":"2013","unstructured":"Vukovic, J. et al. Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering. J. Neurosci. 33, 6603\u20136613. https:\/\/doi.org\/10.1523\/jneurosci.3064-12.2013 (2013).","journal-title":"J. Neurosci."},{"key":"76176_CR13","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/nature06562","volume":"451","author":"CL Zhang","year":"2008","unstructured":"Zhang, C. L., Zou, Y. H., He, W. M., Gage, F. H. & Evans, R. M. A role for adult TLX-positive neural stem cells in learning and behaviour. Nature 451, 1004-U1007. https:\/\/doi.org\/10.1038\/nature06562 (2008).","journal-title":"Nature"},{"key":"76176_CR14","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1523\/jneurosci.3780-09.2010","volume":"30","author":"DJ Jhaveri","year":"2010","unstructured":"Jhaveri, D. J. et al. Norepinephrine directly activates adult hippocampal precursors via \u03b23-adrenergic receptors. J. Neurosci. 30, 2795\u20132806. https:\/\/doi.org\/10.1523\/jneurosci.3780-09.2010 (2010).","journal-title":"J. Neurosci."},{"key":"76176_CR15","doi-asserted-by":"publisher","first-page":"8132","DOI":"10.1523\/jneurosci.0504-15.2015","volume":"35","author":"DJ Jhaveri","year":"2015","unstructured":"Jhaveri, D. J. et al. Purification of neural precursor cells reveals the presence of distinct, stimulus-specific subpopulations of quiescent precursors in the adult mouse hippocampus. J. Neurosci. 35, 8132\u20138144. https:\/\/doi.org\/10.1523\/jneurosci.0504-15.2015 (2015).","journal-title":"J. Neurosci."},{"key":"76176_CR16","doi-asserted-by":"publisher","first-page":"5240","DOI":"10.1523\/jneurosci.0344-08.2008","volume":"28","author":"TL Walker","year":"2008","unstructured":"Walker, T. L. et al. Latent stem and progenitor cells in the hippocampus are activated by neural excitation. J. Neurosci. 28, 5240\u20135247. https:\/\/doi.org\/10.1523\/jneurosci.0344-08.2008 (2008).","journal-title":"J. Neurosci."},{"key":"76176_CR17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.brainres.2009.06.045","volume":"1288","author":"GS Griesbach","year":"2009","unstructured":"Griesbach, G. S., Hovda, D. A. & Gomez-Pinilla, F. Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation. Brain Res. 1288, 105\u2013115. https:\/\/doi.org\/10.1016\/j.brainres.2009.06.045 (2009).","journal-title":"Brain Res."},{"key":"76176_CR18","doi-asserted-by":"publisher","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","volume":"96","author":"H van Praag","year":"1999","unstructured":"van Praag, H., Christie, B. R., Sejnowski, T. J. & Gage, F. H. Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc. Natl. Acad. Sci. U.S.A. 96, 13427\u201313431. https:\/\/doi.org\/10.1073\/pnas.96.23.13427 (1999).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"76176_CR19","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/6368","volume":"2","author":"H van Praag","year":"1999","unstructured":"van Praag, H., Kempermann, G. & Gage, F. H. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat. Neurosci. 2, 266\u2013270. https:\/\/doi.org\/10.1038\/6368\u00a0(1999).","journal-title":"Nat. Neurosci."},{"key":"76176_CR20","doi-asserted-by":"publisher","first-page":"6435","DOI":"10.1523\/jneurosci.5925-11.2012","volume":"32","author":"J Vukovic","year":"2012","unstructured":"Vukovic, J., Colditz, M. J., Blackmore, D. G., Ruitenberg, M. J. & Bartlett, P. F. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. J. Neurosci. 32, 6435\u20136443. https:\/\/doi.org\/10.1523\/jneurosci.5925-11.2012 (2012).","journal-title":"J. Neurosci."},{"key":"76176_CR21","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1017\/s1041610211001980","volume":"24","author":"TB Cumming","year":"2012","unstructured":"Cumming, T. B., Tyedin, K., Churilov, L., Morris, M. E. & Bernhardt, J. The effect of physical activity on cognitive function after stroke: a systematic review. Int. Psychogeriatr. 24, 557\u2013567. https:\/\/doi.org\/10.1017\/s1041610211001980 (2012).","journal-title":"Int. Psychogeriatr."},{"key":"76176_CR22","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1161\/01.Str.30.12.2752","volume":"30","author":"SP Feinklestein","year":"1999","unstructured":"Feinklestein, S. P. et al. Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke 30, 2752\u20132758. https:\/\/doi.org\/10.1161\/01.Str.30.12.2752 (1999).","journal-title":"Stroke"},{"key":"76176_CR23","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1161\/strokeaha.108.541128","volume":"40","author":"M Fisher","year":"2009","unstructured":"Fisher, M. et al. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 40, 2244\u20132250. https:\/\/doi.org\/10.1161\/strokeaha.108.541128 (2009).","journal-title":"Stroke"},{"key":"76176_CR24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neulet.2006.09.040","volume":"409","author":"Y Yagita","year":"2006","unstructured":"Yagita, Y. et al. Postischemic exercise decreases neurogenesis in the adult rat dentate gyrus. Neurosci. Lett. 409, 24\u201329. https:\/\/doi.org\/10.1016\/j.neulet.2006.09.040 (2006).","journal-title":"Neurosci. Lett."},{"key":"76176_CR25","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/jnr.21317","volume":"85","author":"CX Luo","year":"2007","unstructured":"Luo, C. X. et al. Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke. J. Neurosci. Res. 85, 1637\u20131646. https:\/\/doi.org\/10.1002\/jnr.21317 (2007).","journal-title":"J. Neurosci. Res."},{"key":"76176_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cne.10874","volume":"467","author":"JP Brown","year":"2003","unstructured":"Brown, J. P. et al. Transient expression of doublecortin during adult neurogenesis. J. Comp. Neurol. 467, 1\u201310. https:\/\/doi.org\/10.1002\/cne.10874 (2003).","journal-title":"J. Comp. Neurol."},{"key":"76176_CR27","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/hipo.20348","volume":"17","author":"AM Stranahan","year":"2007","unstructured":"Stranahan, A. M., Khalil, D. & Gould, E. Running induces widespread structural alterations in the hippocampus and Entorhinal cortex. Hippocampus 17, 1017\u20131022. https:\/\/doi.org\/10.1002\/hipo.20348 (2007).","journal-title":"Hippocampus"},{"key":"76176_CR28","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1161\/strokeaha.108.536144","volume":"40","author":"K Szabo","year":"2009","unstructured":"Szabo, K. et al. Hippocampal lesion patterns in acute posterior cerebral artery stroke: Clinical and MRI findings. Stroke 40, 2042\u20132045. https:\/\/doi.org\/10.1161\/strokeaha.108.536144 (2009).","journal-title":"Stroke"},{"key":"76176_CR29","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1161\/01.Str.28.9.1805","volume":"28","author":"M Fujii","year":"1997","unstructured":"Fujii, M. et al. Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57Black\/6 mice. Stroke 28, 1805\u20131810. https:\/\/doi.org\/10.1161\/01.Str.28.9.1805 (1997).","journal-title":"Stroke"},{"key":"76176_CR30","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1097\/00004647-199805000-00012","volume":"18","author":"K Kitagawa","year":"1998","unstructured":"Kitagawa, K. et al. Cerebral ischemia after bilateral carotid artery occlusion and intraluminal suture occlusion in mice: evaluation of the patency of the posterior communicating artery. J. Cereb. Blood Flow Metab. 18, 570\u2013579. https:\/\/doi.org\/10.1097\/00004647-199805000-00012 (1998).","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"76176_CR31","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/s0006-8993(97)01217-1","volume":"780","author":"K Murakami","year":"1998","unstructured":"Murakami, K., Kondo, T., Kawase, M. & Chan, P. H. The development of a new mouse model of global ischemia: focus on the relationships between ischemia duration, anesthesia, cerebral vasculature, and neuronal injury following global ischemia in mice. Brain Res. 780, 304\u2013310. https:\/\/doi.org\/10.1016\/s0006-8993(97)01217-1 (1998).","journal-title":"Brain Res."},{"key":"76176_CR32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/s0006-8993(00)02216-2","volume":"868","author":"JC Wellons","year":"2000","unstructured":"Wellons, J. C. et al. A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia. Brain Res. 868, 14\u201321. https:\/\/doi.org\/10.1016\/s0006-8993(00)02216-2 (2000).","journal-title":"Brain Res."},{"key":"76176_CR33","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/s0006-8993(96)01453-9","volume":"752","author":"GM Yang","year":"1997","unstructured":"Yang, G. M. et al. C57BL\/6 strain is most susceptible to cerebral ischemia following bilateral common carotid occlusion among seven mouse strains: Selective neuronal death in the murine transient forebrain ischemia. Brain Res. 752, 209\u2013218. https:\/\/doi.org\/10.1016\/s0006-8993(96)01453-9 (1997).","journal-title":"Brain Res."},{"key":"76176_CR34","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1046\/j.1365-2265.1999.00784.x","volume":"50","author":"PJ Jenkins","year":"1999","unstructured":"Jenkins, P. J. Growth hormone and exercise. Clin. Endocrinol. 50, 683\u2013689. https:\/\/doi.org\/10.1046\/j.1365-2265.1999.00784.x (1999).","journal-title":"Clin. Endocrinol."},{"key":"76176_CR35","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1002\/jnr.20077","volume":"76","author":"S Vaynman","year":"2004","unstructured":"Vaynman, S., Ying, Z. & Gomez-Pinilla, F. Exercise induces BDNF and synapsin I to specific hippocampal subfields. J. Neurosci. Res. 76, 356\u2013362. https:\/\/doi.org\/10.1002\/jnr.20077 (2004).","journal-title":"J. Neurosci. Res."},{"key":"76176_CR36","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/cbin.10022","volume":"37","author":"S Mojtahedi","year":"2013","unstructured":"Mojtahedi, S., Kordi, M. R., Hosseini, S. E., Omran, S. F. & Soleimani, M. Effect of treadmill running on the expression of genes that are involved in neuronal differentiation in the hippocampus of adult male rats. Cell Biol. Int. 37, 276\u2013283. https:\/\/doi.org\/10.1002\/cbin.10022 (2013).","journal-title":"Cell Biol. Int."},{"key":"76176_CR37","doi-asserted-by":"publisher","first-page":"8270","DOI":"10.1523\/jneurosci.5855-12.2013","volume":"33","author":"F Klempin","year":"2013","unstructured":"Klempin, F. et al. Serotonin is required for exercise-induced adult hippocampal neurogenesis. J. Neurosci. 33, 8270\u20138275. https:\/\/doi.org\/10.1523\/jneurosci.5855-12.2013 (2013).","journal-title":"J. Neurosci."},{"key":"76176_CR38","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1073\/pnas.1015950108","volume":"108","author":"KI Erickson","year":"2011","unstructured":"Erickson, K. I. et al. Exercise training increases size of hippocampus and improves memory. Proc. Natl. Acad. Sci. U.S.A. 108, 3017\u20133022. https:\/\/doi.org\/10.1073\/pnas.1015950108 (2011).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"76176_CR39","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/1467-9280.t01-1-01430","volume":"14","author":"S Colcombe","year":"2003","unstructured":"Colcombe, S. & Kramer, A. F. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol. Sci. 14, 125\u2013130. https:\/\/doi.org\/10.1111\/1467-9280.t01-1-01430 (2003).","journal-title":"Psychol. Sci."},{"key":"76176_CR40","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1016\/j.neuroimage.2006.12.040","volume":"35","author":"A Dorr","year":"2007","unstructured":"Dorr, A., Sled, J. G. & Kabani, N. Three-dimensional cerebral vasculature of the CBA mouse brain: a magnetic resonance imaging and micro computed tomography study. Neuroimage 35, 1409\u20131423. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.12.040 (2007).","journal-title":"Neuroimage"},{"key":"76176_CR41","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/mrm.1263","volume":"46","author":"J Biernaskie","year":"2001","unstructured":"Biernaskie, J., Corbett, D., Peeling, J., Wells, J. & Lei, H. A serial MR study of cerebral blood flow changes and lesion development following endothelin-1-induced ischemia in rats. Magn. Reson. Med. 46, 827\u2013830. https:\/\/doi.org\/10.1002\/mrm.1263 (2001).","journal-title":"Magn. Reson. Med."},{"key":"76176_CR42","doi-asserted-by":"publisher","first-page":"3531","DOI":"10.1073\/pnas.051628398","volume":"98","author":"JM Cimadevilla","year":"2001","unstructured":"Cimadevilla, J. M., Wesierska, M., Fenton, A. A. & Bures, J. Inactivating one hippocampus impairs avoidance of a stable room-defined place during dissociation of arena cues from room cues by rotation of the arena. Proc. Natl. Acad. Sci. U.S.A. 98, 3531\u20133536. https:\/\/doi.org\/10.1073\/pnas.051628398 (2001).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"76176_CR43","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/s0092-8674(02)00862-0","volume":"110","author":"H Nakatomi","year":"2002","unstructured":"Nakatomi, H. et al. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110, 429\u2013441. https:\/\/doi.org\/10.1016\/s0092-8674(02)00862-0 (2002).","journal-title":"Cell"},{"key":"76176_CR44","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bbr.2013.04.010","volume":"249","author":"LM Soares","year":"2013","unstructured":"Soares, L. M., Schiavon, A. P., Milani, H. & de Oliveira, R. M. W. Cognitive impairment and persistent anxiety-related responses following bilateral common carotid artery occlusion in mice. Behav. Brain Res. 249, 28\u201337. https:\/\/doi.org\/10.1016\/j.bbr.2013.04.010 (2013).","journal-title":"Behav. Brain Res."},{"key":"76176_CR45","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"2001","unstructured":"Paxinos, G. & Franklin, K. B. J. The Mouse Brain in Stereotaxic Coordinates 2nd edn. (Academic Press, Cambridge, 2001).","edition":"2"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-76176-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-76176-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-76176-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T22:34:46Z","timestamp":1670366086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-76176-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["76176"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-76176-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,6]]},"assertion":[{"value":"22 January 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19269"}}