{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:05:23Z","timestamp":1761491123243},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transpulmonary thermodilution (TPTD)-derived global end-diastolic volume index (GEDVI) is a static marker of preload which better predicted volume responsiveness compared to filling pressures in several studies. GEDVI can be generated with at least two devices: PiCCO and EV-1000. Several studies showed that uncorrected indicator injection into a <jats:italic>femoral<\/jats:italic> central venous catheter (CVC) results in a significant overestimation of GEDVI by the PiCCO-device. Therefore, the most recent PiCCO-algorithm corrects for femoral indicator injection. However, there are no systematic data on the impact of <jats:italic>femoral<\/jats:italic> indicator injection for the EV-1000 device. Furthermore, the correction algorithm of the PiCCO is poorly validated. Therefore, we prospectively analyzed 14 datasets from 10 patients with TPTD-monitoring undergoing central venous catheter (CVC)- and arterial line exchange. PiCCO was replaced by EV-1000, <jats:italic>femoral<\/jats:italic> CVCs were replaced by <jats:italic>jugular<\/jats:italic>\/<jats:italic>subclavian<\/jats:italic> CVCs and vice-versa. For PiCCO, <jats:italic>jugular<\/jats:italic> and <jats:italic>femoral<\/jats:italic> indicator injection derived GEDVI was comparable when the correct information about <jats:italic>femoral<\/jats:italic> catheter site was given (<jats:italic>p<\/jats:italic>\u2009=\u20090.251). By contrast, GEDVI derived from <jats:italic>femoral<\/jats:italic> indicator injection using the EV-1000 was obviously not corrected and was substantially higher than <jats:italic>jugular<\/jats:italic> GEDVI measured by the EV-1000 (846\u2009\u00b1\u2009250 vs. 712\u2009\u00b1\u2009227\u00a0ml\/m<jats:sup>2<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Furthermore, measurements of GEDVI were not comparable between PiCCO and EV-1000 even in case of <jats:italic>jugular<\/jats:italic> indicator injection (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). This is most probably due to different indexations of the raw value GEDV. EV-1000 could not be recommended to measure GEDVI in case of a <jats:italic>femoral<\/jats:italic> CVC. Furthermore, different indexations used by EV-1000 and PiCCO should be considered even in case of a jugular CVC when comparing GEDVI derived from PiCCO and EV-1000.<\/jats:p>","DOI":"10.1038\/s41598-020-76286-w","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T11:03:24Z","timestamp":1606475004000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of global end-diastolic volume index derived from jugular and femoral indicator injection: a prospective observational study in patients equipped with both a PiCCO-2 and an EV-1000-device"],"prefix":"10.1038","volume":"10","author":[{"given":"Alexander","family":"Herner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Heilmaier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland M.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"76286_CR1","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s00134-002-1211-z","volume":"28","author":"DA Reuter","year":"2002","unstructured":"Reuter, D. 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All other authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing of Interests"}}],"article-number":"20773"}}