{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:05:23Z","timestamp":1793480723132,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Taiwanese Ministry of Health and Welfare","award":["MOHW107-TDU-B-212-123005"],"award-info":[{"award-number":["MOHW107-TDU-B-212-123005"]}]},{"name":"Taiwanese Ministry of Health and Welfare","award":["MOHW108-TDU-B-212-133005"],"award-info":[{"award-number":["MOHW108-TDU-B-212-133005"]}]},{"name":"Taiwanese Ministry of Health and Welfare","award":["MOHW104-TDU-B-212-113003"],"award-info":[{"award-number":["MOHW104-TDU-B-212-113003"]}]},{"name":"Taiwanese Ministry of Health and Welfare","award":["MOHW105-TDU-B-212-13302"],"award-info":[{"award-number":["MOHW105-TDU-B-212-13302"]}]},{"name":"Taiwanese Ministry of Health and Welfare","award":["MOHW106-TDU-B-212-113005"],"award-info":[{"award-number":["MOHW106-TDU-B-212-113005"]}]},{"name":"Chang Gung Memorial Hospital Research Fund","award":["CMRPG3F2181"],"award-info":[{"award-number":["CMRPG3F2181"]}]},{"name":"Chang Gung Memorial Hospital Research Fund","award":["BMRPD69"],"award-info":[{"award-number":["BMRPD69"]}]},{"name":"Chang Gung Memorial Hospital Research Fund","award":["CORPG3J0342"],"award-info":[{"award-number":["CORPG3J0342"]}]},{"name":"Ministry of Science and Technology","award":["MOST 106-2314-B-182A-026-MY3"],"award-info":[{"award-number":["MOST 106-2314-B-182A-026-MY3"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The associations of <jats:sup>18<\/jats:sup>F-THK5351 tau positron emission tomography (PET) findings with core domains of progressive supranuclear palsy (PSP) and its diagnostic certainty have yet to be fully elucidated. The <jats:sup>18<\/jats:sup>F-THK5351 PET patterns of 17 patients with PSP (68.9\u2009\u00b1\u20096.5\u00a0years; 8 women) were compared with those observed in 28 age-matched and sex-matched (66.2\u2009\u00b1\u20094.5\u00a0years, 18 women) control subjects (CS). Tracer accumulation\u2014as reflected by standardized uptake value ratios (SUVRs) and z-scores\u2014was correlated with core domains of PSP and different levels of diagnostic certainty. Compared with CS, patients with PSP showed an increased <jats:sup>18<\/jats:sup>F-THK5351 uptake in the globus pallidus and red nucleus. Patients with PSP and oculomotor dysfunction had significantly higher SUVRs in the midbrain, red nucleus, and raphe nucleus than those without. In addition, cases who meet criteria for level 1 (highest) certainty in the postural instability domain showed significantly higher SUVRs in the frontal, parietal, precuneus, and sensory-motor cortex. Patients with probable PSP had significantly higher SUVR values than those with possible PSP in multiple cortical (i.e., frontal, parietal, temporal, anterior cingulate gyrus, precuneus, and sensory-motor gyrus) and subcortical (i.e., putamen, thalamus, and raphe nucleus) regions. Patterns of <jats:sup>18<\/jats:sup>F-THK5351 uptake were correlated to core domains of PSP\u2014including oculomotor dysfunction and postural instability. Moreover, the degree of diagnostic certainty for PSP was appreciably associated with <jats:sup>18<\/jats:sup>F-THK5351 PET findings.<\/jats:p>","DOI":"10.1038\/s41598-020-76339-0","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T11:02:41Z","timestamp":1605006161000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["18F-THK5351 PET imaging in patients with progressive supranuclear palsy: associations with core domains and diagnostic certainty"],"prefix":"10.1038","volume":"10","author":[{"given":"Jung-Lung","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Hsin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ing-Tsung","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Song","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Chen","family":"Yen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Ju","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hsin","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"76339_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1001\/archneur.1964.00460160003001","volume":"10","author":"JC Steele","year":"1964","unstructured":"Steele, J. C., Richardson, J. C. & Olszewski, J. Progressive supranuclear palsy. A heterogeneous degeneration involving the brain stem, basal ganglia and cerebellum with vertical gaze and pseudobulbar palsy, nuchal dystonia and dementia. Arch. Neurol. 10, 333\u2013359. https:\/\/doi.org\/10.1001\/archneur.1964.00460160003001 (1964).","journal-title":"Arch. Neurol."},{"key":"76339_CR2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1097\/WCO.0b013e32833be924","volume":"23","author":"DW Dickson","year":"2010","unstructured":"Dickson, D. W., Ahmed, Z., Algom, A. A., Tsuboi, Y. & Josephs, K. A. Neuropathology of variants of progressive supranuclear palsy. Curr. Opin. Neurol. 23, 394\u2013400. https:\/\/doi.org\/10.1097\/WCO.0b013e32833be924 (2010).","journal-title":"Curr. Opin. Neurol."},{"key":"76339_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/nan.12208","volume":"41","author":"GG Kovacs","year":"2015","unstructured":"Kovacs, G. G. Invited review: Neuropathology of tauopathies: Principles and practice. Neuropathol. Appl. Neurobiol. 41, 3\u201323. https:\/\/doi.org\/10.1111\/nan.12208 (2015).","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"76339_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/00005072-199601000-00010","volume":"55","author":"I Litvan","year":"1996","unstructured":"Litvan, I. et al. Validity and reliability of the preliminary NINDS neuropathologic criteria for progressive supranuclear palsy and related disorders. J. Neuropathol. Exp. Neurol. 55, 97\u2013105. https:\/\/doi.org\/10.1097\/00005072-199601000-00010 (1996).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"76339_CR5","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.cger.2019.09.014","volume":"36","author":"S Caproni","year":"2020","unstructured":"Caproni, S. & Colosimo, C. Diagnosis and differential diagnosis of Parkinson disease. Clin. Geriatr. Med. 36, 13\u201324. https:\/\/doi.org\/10.1016\/j.cger.2019.09.014 (2020).","journal-title":"Clin. Geriatr. Med."},{"key":"76339_CR6","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1212\/CON.0000000000000751","volume":"25","author":"P Greene","year":"2019","unstructured":"Greene, P. Progressive supranuclear palsy, corticobasal degeneration, and multiple system atrophy. Continuum (Minneap Minn) 25, 919\u2013935. https:\/\/doi.org\/10.1212\/CON.0000000000000751 (2019).","journal-title":"Continuum (Minneap Minn)"},{"key":"76339_CR7","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/mds.27619","volume":"34","author":"F Ali","year":"2019","unstructured":"Ali, F. et al. Sensitivity and specificity of diagnostic criteria for progressive supranuclear palsy. Mov. Disord. 34, 1144\u20131153. https:\/\/doi.org\/10.1002\/mds.27619 (2019).","journal-title":"Mov. Disord."},{"key":"76339_CR8","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/mds.26987","volume":"32","author":"GU Hoglinger","year":"2017","unstructured":"Hoglinger, G. U. et al. Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Mov. Disord. 32, 853\u2013864. https:\/\/doi.org\/10.1002\/mds.26987 (2017).","journal-title":"Mov. Disord."},{"key":"76339_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1212\/wnl.47.1.1","volume":"47","author":"I Litvan","year":"1996","unstructured":"Litvan, I. et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP international workshop. Neurology 47, 1\u20139. https:\/\/doi.org\/10.1212\/wnl.47.1.1 (1996).","journal-title":"Neurology"},{"key":"76339_CR10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11910-018-0819-5","volume":"18","author":"MJ Armstrong","year":"2018","unstructured":"Armstrong, M. J. Progressive supranuclear palsy: An update. Curr. Neurol. Neurosci. Rep. 18, 12. https:\/\/doi.org\/10.1007\/s11910-018-0819-5 (2018).","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"76339_CR11","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1002\/mds.27038","volume":"32","author":"JL Whitwell","year":"2017","unstructured":"Whitwell, J. L. et al. Radiological biomarkers for diagnosis in PSP: Where are we and where do we need to be?. Mov. Disord. 32, 955\u2013971. https:\/\/doi.org\/10.1002\/mds.27038 (2017).","journal-title":"Mov. Disord."},{"key":"76339_CR12","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00234-012-1132-7","volume":"55","author":"M Tripathi","year":"2013","unstructured":"Tripathi, M. et al. Differential diagnosis of parkinsonian syndromes using F-18 fluorodeoxyglucose positron emission tomography. Neuroradiology 55, 483\u2013492. https:\/\/doi.org\/10.1007\/s00234-012-1132-7 (2013).","journal-title":"Neuroradiology"},{"key":"76339_CR13","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1002\/1531-8257(200011)15:6<1158::aid-mds1015>3.0.co;2-0","volume":"15","author":"W Pirker","year":"2000","unstructured":"Pirker, W. et al. [123I]beta-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. Mov. Disord. 15, 1158\u20131167. https:\/\/doi.org\/10.1002\/1531-8257(200011)15:6%3c1158::aid-mds1015%3e3.0.co;2-0 (2000).","journal-title":"Mov. Disord."},{"key":"76339_CR14","first-page":"384","volume":"47","author":"K Van Laere","year":"2006","unstructured":"Van Laere, K. et al. Dual-tracer dopamine transporter and perfusion SPECT in differential diagnosis of parkinsonism using template-based discriminant analysis. J. Nucl. Med. 47, 384\u2013392 (2006).","journal-title":"J. Nucl. Med."},{"key":"76339_CR15","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/s41380-018-0342-8","volume":"24","author":"A Leuzy","year":"2019","unstructured":"Leuzy, A. et al. Tau PET imaging in neurodegenerative tauopathies-still a challenge. Mol. Psychiatry 24, 1112\u20131134. https:\/\/doi.org\/10.1038\/s41380-018-0342-8 (2019).","journal-title":"Mol. Psychiatry"},{"key":"76339_CR16","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/mds.26813","volume":"32","author":"R Smith","year":"2017","unstructured":"Smith, R. et al. Increased basal ganglia binding of (18) F-AV-1451 in patients with progressive supranuclear palsy. Mov. Disord. 32, 108\u2013114. https:\/\/doi.org\/10.1002\/mds.26813 (2017).","journal-title":"Mov. Disord."},{"key":"76339_CR17","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/mds.26834","volume":"32","author":"JL Whitwell","year":"2017","unstructured":"Whitwell, J. L. et al. [(18) F]AV-1451 tau positron emission tomography in progressive supranuclear palsy. Mov. Disord. 32, 124\u2013133. https:\/\/doi.org\/10.1002\/mds.26834 (2017).","journal-title":"Mov. Disord."},{"key":"76339_CR18","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1002\/mds.26844","volume":"32","author":"H Cho","year":"2017","unstructured":"Cho, H. et al. Subcortical (18) F-AV-1451 binding patterns in progressive supranuclear palsy. Mov. Disord. 32, 134\u2013140. https:\/\/doi.org\/10.1002\/mds.26844 (2017).","journal-title":"Mov. Disord."},{"key":"76339_CR19","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1002\/mds.27546","volume":"34","author":"JL Whitwell","year":"2019","unstructured":"Whitwell, J. L. et al. MRI outperforms [18F]AV-1451 PET as a longitudinal biomarker in progressive supranuclear palsy. Mov. Disord. 34, 105\u2013113. https:\/\/doi.org\/10.1002\/mds.27546 (2019).","journal-title":"Mov. Disord."},{"key":"76339_CR20","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00401-016-1650-1","volume":"133","author":"R Smith","year":"2017","unstructured":"Smith, R. et al. Tau neuropathology correlates with FDG-PET, but not AV-1451-PET, in progressive supranuclear palsy. Acta Neuropathol. 133, 149\u2013151. https:\/\/doi.org\/10.1007\/s00401-016-1650-1 (2017).","journal-title":"Acta Neuropathol."},{"key":"76339_CR21","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13195-017-0253-y","volume":"9","author":"KP Ng","year":"2017","unstructured":"Ng, K. P. et al. Monoamine oxidase B inhibitor, selegiline, reduces (18)F-THK5351 uptake in the human brain. Alzheimer\u2019s Res. Ther. 9, 25\u201325. https:\/\/doi.org\/10.1186\/s13195-017-0253-y (2017).","journal-title":"Alzheimer's Res. Ther."},{"key":"76339_CR22","doi-asserted-by":"publisher","first-page":"102091","DOI":"10.1016\/j.nicl.2019.102091","volume":"24","author":"KP Ng","year":"2019","unstructured":"Ng, K. P. et al. Rasagiline, a monoamine oxidase B inhibitor, reduces in vivo [(18)F]THK5351 uptake in progressive supranuclear palsy. Neuroimage Clin. 24, 102091\u2013102091. https:\/\/doi.org\/10.1016\/j.nicl.2019.102091 (2019).","journal-title":"Neuroimage Clin."},{"key":"76339_CR23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s40478-018-0556-7","volume":"6","author":"A Ishiki","year":"2018","unstructured":"Ishiki, A. et al. Neuroimaging-pathological correlations of [(18)F]THK5351 PET in progressive supranuclear palsy. Acta Neuropathol. Commun. 6, 53. https:\/\/doi.org\/10.1186\/s40478-018-0556-7 (2018).","journal-title":"Acta Neuropathol. Commun."},{"key":"76339_CR24","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3389\/fnagi.2017.00440","volume":"9","author":"M Brendel","year":"2017","unstructured":"Brendel, M. et al. [(18)F]-THK5351 PET correlates with topology and symptom severity in progressive supranuclear palsy. Front. Aging Neurosci. 9, 440. https:\/\/doi.org\/10.3389\/fnagi.2017.00440 (2017).","journal-title":"Front. Aging Neurosci."},{"key":"76339_CR25","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/ene.13164","volume":"24","author":"A Ishiki","year":"2017","unstructured":"Ishiki, A. et al. Tau imaging with [(18) F]THK-5351 in progressive supranuclear palsy. Eur. J. Neurol. 24, 130\u2013136. https:\/\/doi.org\/10.1111\/ene.13164 (2017).","journal-title":"Eur. J. Neurol."},{"key":"76339_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13195-015-0156-8","volume":"7","author":"JL Hsu","year":"2015","unstructured":"Hsu, J. L. et al. Improved predictive ability of the Montreal Cognitive Assessment for diagnosing dementia in a community-based study. Alzheimer\u2019s Res. Ther. 7, 69. https:\/\/doi.org\/10.1186\/s13195-015-0156-8 (2015).","journal-title":"Alzheimer's Res. Ther."},{"key":"76339_CR27","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.2967\/jnumed.116.189126","volume":"58","author":"IT Hsiao","year":"2017","unstructured":"Hsiao, I. T. et al. Biodistribution and radiation dosimetry for the Tau Tracer (18)F-THK-5351 in healthy human subjects. J. Nucl. Med. 58, 1498\u20131503. https:\/\/doi.org\/10.2967\/jnumed.116.189126 (2017).","journal-title":"J. Nucl. Med."},{"key":"76339_CR28","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s13195-019-0566-0","volume":"11","author":"SY Lin","year":"2019","unstructured":"Lin, S. Y. et al. Plasma amyloid assay as a pre-screening tool for amyloid positron emission tomography imaging in early stage Alzheimer\u2019s disease. Alzheimer\u2019s Res. Ther. 11, 111. https:\/\/doi.org\/10.1186\/s13195-019-0566-0 (2019).","journal-title":"Alzheimer's Res. Ther."},{"key":"76339_CR29","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","volume":"26","author":"J Ashburner","year":"2005","unstructured":"Ashburner, J. & Friston, K. J. Unified segmentation. Neuroimage 26, 839\u2013851. https:\/\/doi.org\/10.1016\/j.neuroimage.2005.02.018 (2005).","journal-title":"Neuroimage"},{"key":"76339_CR30","doi-asserted-by":"publisher","first-page":"16027","DOI":"10.1038\/s41598-018-34388-6","volume":"8","author":"H Jung Lung","year":"2018","unstructured":"Jung Lung, H., Weng, Y. H., Wen, M. C., Hsiao, I. T. & Lin, K. J. Quantitative study of (18)F-(+)DTBZ image: Comparison of PET template-based and MRI based image analysis. Sci. Rep. 8, 16027. https:\/\/doi.org\/10.1038\/s41598-018-34388-6 (2018).","journal-title":"Sci. Rep."},{"key":"76339_CR31","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.neuroimage.2016.12.077","volume":"147","author":"G Gonzalez-Escamilla","year":"2017","unstructured":"Gonzalez-Escamilla, G. et al. PETPVE12: An SPM toolbox for partial volume effects correction in brain PET\u2014Application to amyloid imaging with AV45-PET. Neuroimage 147, 669\u2013677. https:\/\/doi.org\/10.1016\/j.neuroimage.2016.12.077 (2017).","journal-title":"Neuroimage"},{"key":"76339_CR32","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","volume":"38","author":"J Ashburner","year":"2007","unstructured":"Ashburner, J. A fast diffeomorphic image registration algorithm. Neuroimage 38, 95\u2013113. https:\/\/doi.org\/10.1016\/j.neuroimage.2007.07.007 (2007).","journal-title":"Neuroimage"},{"key":"76339_CR33","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1176\/appi.ajp.162.7.1256","volume":"162","author":"JA Frazier","year":"2005","unstructured":"Frazier, J. A. et al. Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. Am. J. Psychiatry 162, 1256\u20131265. https:\/\/doi.org\/10.1176\/appi.ajp.162.7.1256 (2005).","journal-title":"Am. J. Psychiatry"},{"key":"76339_CR34","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1212\/WNL.0b013e318292a2d2","volume":"80","author":"LA Massey","year":"2013","unstructured":"Massey, L. A. et al. The midbrain to pons ratio: A simple and specific MRI sign of progressive supranuclear palsy. Neurology 80, 1856\u20131861. https:\/\/doi.org\/10.1212\/WNL.0b013e318292a2d2 (2013).","journal-title":"Neurology"},{"key":"76339_CR35","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1093\/brain\/aww340","volume":"140","author":"L Passamonti","year":"2017","unstructured":"Passamonti, L. et al. 18F-AV-1451 positron emission tomography in Alzheimer\u2019s disease and progressive supranuclear palsy. Brain 140, 781\u2013791. https:\/\/doi.org\/10.1093\/brain\/aww340 (2017).","journal-title":"Brain"},{"key":"76339_CR36","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40478-016-0315-6","volume":"4","author":"VJ Lowe","year":"2016","unstructured":"Lowe, V. J. et al. An autoradiographic evaluation of AV-1451 Tau PET in dementia. Acta Neuropathol. Commun. 4, 58. https:\/\/doi.org\/10.1186\/s40478-016-0315-6 (2016).","journal-title":"Acta Neuropathol. Commun."},{"key":"76339_CR37","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1016\/j.jalz.2016.01.003","volume":"12","author":"K Sander","year":"2016","unstructured":"Sander, K. et al. Characterization of tau positron emission tomography tracer [(18)F]AV-1451 binding to postmortem tissue in Alzheimer\u2019s disease, primary tauopathies, and other dementias. Alzheimers Dement. 12, 1116\u20131124. https:\/\/doi.org\/10.1016\/j.jalz.2016.01.003 (2016).","journal-title":"Alzheimers Dement."},{"key":"76339_CR38","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00429-017-1507-y","volume":"223","author":"S Coakeley","year":"2018","unstructured":"Coakeley, S. et al. [(18)F]AV-1451 binding to neuromelanin in the substantia nigra in PD and PSP. Brain Struct. Funct. 223, 589\u2013595. https:\/\/doi.org\/10.1007\/s00429-017-1507-y (2018).","journal-title":"Brain Struct. Funct."},{"key":"76339_CR39","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1097\/rlu.0000000000003164","volume":"45","author":"JL Hsu","year":"2020","unstructured":"Hsu, J. L. et al. The imaging features and clinical associations of a novel Tau PET Tracer-18F-APN1607 in Alzheimer disease. Clin. Nucl. Med. 45, 747\u2013756. https:\/\/doi.org\/10.1097\/rlu.0000000000003164 (2020).","journal-title":"Clin. Nucl. Med."},{"key":"76339_CR40","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25071750","author":"CC Weng","year":"2020","unstructured":"Weng, C. C. et al. Characterization of (18)F-PM-PBB3 ((18)F-APN-1607) uptake in the rTg4510 mouse model of tauopathy. Molecules (Basel, Switzerland). https:\/\/doi.org\/10.3390\/molecules25071750 (2020).","journal-title":"Molecules (Basel, Switzerland)."},{"key":"76339_CR41","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.parkreldis.2019.02.022","volume":"63","author":"A Quattrone","year":"2019","unstructured":"Quattrone, A. et al. Imaging counterpart of postural instability and vertical ocular dysfunction in patients with PSP: A multimodal MRI study. Parkinson. Relat. Disord. 63, 124\u2013130. https:\/\/doi.org\/10.1016\/j.parkreldis.2019.02.022 (2019).","journal-title":"Parkinson. Relat. Disord."},{"key":"76339_CR42","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1002\/mds.25437","volume":"28","author":"KA Josephs","year":"2013","unstructured":"Josephs, K. A. et al. Modeling trajectories of regional volume loss in progressive supranuclear palsy. Mov. Disord. 28, 1117\u20131124. https:\/\/doi.org\/10.1002\/mds.25437 (2013).","journal-title":"Mov. Disord."},{"key":"76339_CR43","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1212\/WNL.0000000000003125","volume":"87","author":"A Quattrone","year":"2016","unstructured":"Quattrone, A. et al. MR parkinsonism index predicts vertical supranuclear gaze palsy in patients with PSP-parkinsonism. Neurology 87, 1266\u20131273. https:\/\/doi.org\/10.1212\/WNL.0000000000003125 (2016).","journal-title":"Neurology"},{"key":"76339_CR44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.parkreldis.2013.09.017","volume":"20","author":"LL Chan","year":"2014","unstructured":"Chan, L. L. et al. Transcallosal diffusion tensor abnormalities in predominant gait disorder parkinsonism. Parkinson. Relat. Disord. 20, 53\u201359. https:\/\/doi.org\/10.1016\/j.parkreldis.2013.09.017 (2014).","journal-title":"Parkinson. Relat. Disord."},{"key":"76339_CR45","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1212\/WNL.0b013e318223c79d","volume":"77","author":"A Zwergal","year":"2011","unstructured":"Zwergal, A. et al. Postural imbalance and falls in PSP correlate with functional pathology of the thalamus. Neurology 77, 101\u2013109. https:\/\/doi.org\/10.1212\/WNL.0b013e318223c79d (2011).","journal-title":"Neurology"},{"key":"76339_CR46","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s40478-016-0391-7","volume":"4","author":"C Kurz","year":"2016","unstructured":"Kurz, C. et al. An autopsy-confirmed case of progressive supranuclear palsy with predominant postural instability. Acta Neuropathol. Commun. 4, 120. https:\/\/doi.org\/10.1186\/s40478-016-0391-7 (2016).","journal-title":"Acta Neuropathol. Commun."},{"key":"76339_CR47","doi-asserted-by":"publisher","first-page":"249","DOI":"10.3389\/fnagi.2019.00249","volume":"11","author":"S Schonecker","year":"2019","unstructured":"Schonecker, S. et al. PET imaging of astrogliosis and tau facilitates diagnosis of Parkinsonian syndromes. Front. Aging Neurosci. 11, 249. https:\/\/doi.org\/10.3389\/fnagi.2019.00249 (2019).","journal-title":"Front. Aging Neurosci."},{"key":"76339_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27092","author":"F Jacobacci","year":"2020","unstructured":"Jacobacci, F. et al. Improving Spatial normalization of brain diffusion MRI to measure longitudinal changes of tissue microstructure in the cortex and white matter. J. Magn. Reson. Imaging https:\/\/doi.org\/10.1002\/jmri.27092 (2020).","journal-title":"J. Magn. Reson. Imaging"}],"updated-by":[{"DOI":"10.1038\/s41598-021-83535-z","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T00:00:00Z","timestamp":1612828800000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-76339-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-76339-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-76339-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T22:58:47Z","timestamp":1670367527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-76339-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,10]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["76339"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-76339-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,10]]},"assertion":[{"value":"13 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-021-83535-z","URL":"https:\/\/doi.org\/10.1038\/s41598-021-83535-z","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19410"}}