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A total of 540 individuals (\u2265\u200918\u00a0years old) participated in both phase of the study. Participants were categorized into 3 categories of regressed, progressed and unchanged metabolic syndrome (MetS). Demographic, anthropometric and biochemical parameters were assessed for each individual in both phase. Variables differences (delta: \u0394) between the two phase of study were calculated. Unchanged group was considered as baseline category. Based on IDF, MetS had been regressed and progressed in 42 participants (7.7%) and 112 (20.7%) participants respectively, in the second phase. More than 47% of people, whose MetS regressed, experienced also NAFLD regression. Results of multiple variable analysis revealed that increased age, positive \u0394-TG, and \u0394-FBS, significantly increased the odds of MetS progression based on IDF and ATP III definitions, while negative \u0394-HDL and \u0394-neutrophil to lymph ration increased the odds of progression. On the other hand, negative \u0394-TG and positive \u0394-HDL significantly increased the odds of Mets regression based of both IDF and ATP III. 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