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We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment for AUD between 2013 and 2017 were eligible (77% men); age at admission was 47\u00a0years [interquartile range (IQR), 40\u201353\u00a0years], age of onset of alcohol consumption was 16\u00a0years [IQR, 16\u201318\u00a0years] and the amount of alcohol consumed was 160\u00a0g\/day [IQR, 120\u2013240\u00a0g\/day]. Body Mass Index was 24.7\u00a0kg\/m<jats:sup>2<\/jats:sup> [IQR, 21.9\u201328.4\u00a0kg\/m<jats:sup>2<\/jats:sup>], eGFR was 105\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> [IQR, 95.7\u2013113.0\u00a0mL], 9.7% had metabolic syndrome and 23% had advanced liver fibrosis (FIB-4\u2009&gt;\u20093.25). Prevalence of hyperuricemia was 12.5%. The eGFR-adjusted multivariate analysis showed that relative to patients with GGT\u2009\u2264\u200950, those with GGT between 51 and 300\u00a0U\/L and those with GGT\u2009&gt;\u2009300\u00a0U\/L were 4.31 (95% CI 1.62\u201311.46) and 10.3 (95% CI 3.50\u201329.90) times more likely to have hyperuricemia, respectively. Our data shows that hyperuricemia in the context of AUD is strongly associated with serum GGT levels and suggest an increased cardio-metabolic risk in this population.<\/jats:p>","DOI":"10.1038\/s41598-020-77013-1","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T11:05:54Z","timestamp":1605697554000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of hyperuricemia and gamma glutamyl transferase as a marker of metabolic risk in alcohol use disorder"],"prefix":"10.1038","volume":"10","author":[{"given":"Anna","family":"Hern\u00e1ndez-Rubio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantza","family":"Sanvisens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferran","family":"Bolao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"P\u00e9rez-Ma\u00f1\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Garc\u00eda-Marchena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Fern\u00e1ndez-Prendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Muga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"77013_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","volume":"213","author":"J Maiuolo","year":"2016","unstructured":"Maiuolo, J., Oppedisano, F., Gratteri, S., Muscoli, C. & Mollace, V. 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