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We recently reported that alcohol-induced hepatic retinoid mobilization is impaired in <jats:italic>Cd36<\/jats:italic>\n            <jats:sup>\n              <jats:italic>\u2212\/\u2212<\/jats:italic>\n            <\/jats:sup> mice, leading us to hypothesize that CD36 has a novel role in hepatic vitamin A mobilization. Given the central role of the liver in systemic vitamin A homeostasis we also postulated that absence of CD36 would affect whole-body vitamin A homeostasis. We tested this hypothesis in aging wild type and <jats:italic>Cd36<\/jats:italic>\n            <jats:sup>\n              <jats:italic>\u2212\/\u2212<\/jats:italic>\n            <\/jats:sup> mice, as well as mice fed a vitamin A-deficient diet. In agreement with our hypothesis, <jats:italic>Cd36<\/jats:italic>\n            <jats:sup>\n              <jats:italic>\u2212\/\u2212<\/jats:italic>\n            <\/jats:sup> mice accumulated hepatic retinyl ester stores with age to a greater extent than wild type mice. However, contrary to expectations, <jats:italic>Cd36<\/jats:italic>\n            <jats:sup>\n              <jats:italic>\u2212\/\u2212<\/jats:italic>\n            <\/jats:sup> mice consuming a vitamin A-deficient diet mobilized hepatic retinoid similar to wild type mice. Interestingly, we observed that <jats:italic>Cd36<\/jats:italic>\n            <jats:sup>\n              <jats:italic>\u2212\/\u2212<\/jats:italic>\n            <\/jats:sup> mice had significantly reduced white adipose tissue retinoid levels compared to wild type mice. In conclusion, we demonstrate that the absence of CD36 alters whole-body vitamin A homeostasis.<\/jats:p>","DOI":"10.1038\/s41598-020-77411-5","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T11:14:02Z","timestamp":1606130042000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Absence of CD36 alters systemic vitamin A homeostasis"],"prefix":"10.1038","volume":"10","author":[{"given":"Michael J.","family":"Trites","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Febbraio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin D.","family":"Clugston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"77411_CR1","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/neu.20242","volume":"66","author":"R Blomhoff","year":"2006","unstructured":"Blomhoff, R. & Blomhoff, H. 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