{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T19:38:38Z","timestamp":1774294718460,"version":"3.50.1"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate a new method of measuring the intraocular pressure (IOP) in the vitreous cavity. IOPs in the anterior chamber and vitreous cavities of 24 porcine eyes (12 eyes with lenses and 12 eyes without lenses) were measured directly, continuously, and simultaneously. We used a needle as a part of the pressure sensor to measure the anterior chamber IOP and a disk-shaped sensor to measure the vitreous cavity IOP. A significant group-by-condition interaction on the vitreous cavity IOP between the two groups (phakia and aphakia) and four conditions of anterior chamber IOP were observed (F[3,258]\u2009=\u20095.8564, p\u2009&lt;\u20090.001). A positive correlation was observed between the vitreous cavity IOP and anterior chamber IOP in both the phakia group (R\u2009=\u20090.96, p\u2009&lt;\u20090.001) and the aphakia group (R\u2009=\u20090.97, p\u2009&lt;\u20090.001). No significant correlation was observed between the \u0394IOPv-a (vitreous cavity IOP\u2009\u2212\u2009anterior chamber IOP) and anterior chamber IOP in either group (phakia group: R\u2009=\u2009\u2009\u2212\u20090.18, p\u2009=\u20090.034; aphakia group: R\u2009=\u2009\u2009\u2212\u20090.029, p\u2009=\u20090.73). The vitreous cavity IOP measured with the new sensor was well-correlated with the anterior chamber IOP in the physiological range tested.<\/jats:p>","DOI":"10.1038\/s41598-020-77633-7","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T11:03:44Z","timestamp":1606302224000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Investigation of intraocular pressure of the anterior chamber and vitreous cavity of porcine eyes via a novel method"],"prefix":"10.1038","volume":"10","author":[{"given":"Koji","family":"Nagae","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromasa","family":"Sawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Aihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,25]]},"reference":[{"key":"77633_CR1","first-page":"146","volume":"43","author":"M Aihara","year":"2002","unstructured":"Aihara, M., Lindsey, J. D. & Wienreb, R. N. Reduction of intraocular pressure in mouse eyes treated with latanoprost. Investig. Ophthalmol. Vis. Sci. 43, 146\u2013150 (2002).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"77633_CR2","first-page":"249","volume":"38","author":"SW John","year":"1997","unstructured":"John, S. W., Hagaman, J. R., MacTaggart, T. E., Peng, L. & Smithes, O. Intraocular pressure in inbred mouse strains. Investig. Ophthalmol. Vis. Sci. 38, 249\u2013253 (1997).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"77633_CR3","first-page":"940","volume":"37","author":"LS Abrams","year":"1996","unstructured":"Abrams, L. S., Vitale, S. & Jamepel, H. D. Comparison of three tonometers for measuring intraocular pressure in rabbits. Investig. Ophthalmol. Vis. Sci. 37, 940\u2013944 (1996).","journal-title":"Investig. Ophthalmol. Vis. 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RSC Adv. 8, 36999\u201337007 (2018).","journal-title":"RSC Adv."},{"key":"77633_CR8","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00417-011-1617-9","volume":"249","author":"I Sanchez","year":"2011","unstructured":"Sanchez, I., Martin, R., Ussa, F. & Fernandez-Bueno, I. The parameters of the porcine eyeball. Graefes Arch. Clin. Exp. Ophthalmol. 249, 475\u2013482 (2011).","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"77633_CR9","first-page":"4820167","volume":"2019","author":"W Wang","year":"2019","unstructured":"Wang, W., Song, H. & Liu, Z. Computational study on the biomechanics of pupil block phenomenon. BioMed Res. Int. 2019, 4820167 (2019).","journal-title":"BioMed Res. Int."},{"key":"77633_CR10","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1167\/iovs.17-22890","volume":"59","author":"NW El-Nimri","year":"2018","unstructured":"El-Nimri, N. W. & Wildsoet, C. F. Effects of topical latanoprost on intraocular pressure and myopia progression in young guinea pigs. Investig. Ophthalmol. Vis. Sci. 59, 2644\u20132651 (2018).","journal-title":"Investig. Ophthalmol. Vis. 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