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But its role in stable coronary artery disease (CAD) has not been fully elucidated. This study aimed to identify the relationship between the circulating galectin-1 level and the severity of CAD in patients with suspected CAD. Pre-procedure galectin-1 and high-sensitivity C-reactive protein (hs-CRP) concentrations were measured in 834 subjects who underwent scheduled coronary angiography. Subjects were grouped into tertiles of the galectin-1 levels. SYNTAX scores were calculated to evaluate the severity of CAD. All patients were followed until January 2019 or the occurrence of major adverse cardiovascular events (MACE). Patients with higher galectin-1 concentrations were older; had greater prevalence of hypertension, diabetes, chronic kidney disease, and heart failure; and were more likely to present with higher hs-CRP levels and SYNTAX scores. During the follow-up period of 1.3\u2009\u00b1\u20091.1\u00a0years, patients in the highest tertile of galectin-1 were associated with a greater risk of MACE after adjustment for age, sex, comorbidities, co-medications, serum levels of hemoglobin, creatinine, hs-CRP, ejection fraction, SYNTAX scores, and revascularization modalities (adjusted hazard ratio 10.95, 95% confidence interval 2.29\u201352.47, <jats:italic>p<\/jats:italic>\u2009=\u20090.003). Galectin-1 showed better discriminatory performance than hs-CRP, and non-inferior performance to SYNTAX scores, in predicting the incidence of MACE.<\/jats:p>","DOI":"10.1038\/s41598-020-77804-6","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T11:03:50Z","timestamp":1606388630000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Galectin-1 is associated with the severity of coronary artery disease and adverse cardiovascular events in patients undergoing coronary angiography"],"prefix":"10.1038","volume":"10","author":[{"given":"Ruey-Hsing","family":"Chou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-Sung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Sung","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen-Chih","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Lin","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Wen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Chin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Hsun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shing-Jong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"77804_CR1","doi-asserted-by":"crossref","first-page":"20807","DOI":"10.1016\/S0021-9258(17)31891-4","volume":"269","author":"SH Barondes","year":"1994","unstructured":"Barondes, S. H., Cooper, D. N., Gitt, M. A. & Leffler, H. Galectins, structure and function of a large family of animal lectins. J. Biol. Chem. 269, 20807\u201320810 (1994).","journal-title":"J. Biol. Chem."},{"key":"77804_CR2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.coi.2016.12.003","volume":"45","author":"SP Mendez-Huergo","year":"2017","unstructured":"Mendez-Huergo, S. P., Blidner, A. G. & Rabinovich, G. A. Galectins, emerging regulatory checkpoints linking tumor immunity and angiogenesis. Curr. Opin. Immunol. 45, 8\u201315 (2017).","journal-title":"Curr. Opin. Immunol."},{"key":"77804_CR3","doi-asserted-by":"publisher","first-page":"9186940","DOI":"10.1155\/2018\/9186940","volume":"2018","author":"MF Brinchmann","year":"2018","unstructured":"Brinchmann, M. F., Patel, D. M. & Iversen, M. H. The role of galectins as modulators of metabolism and inflammation. Mediat. Inflamm. 2018, 9186940 (2018).","journal-title":"Mediat. 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