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These could be secondary infections derived from opportunistic bacteria on the skin or infections directly vectored by the spider. In this study, we investigated whether it is plausible for <jats:italic>S. nobilis<\/jats:italic> and other synanthropic European spiders to vector bacteria during a bite, by seeking to identify bacteria with pathogenic potential on the spiders. 11 genera of bacteria were identified through 16S rRNA sequencing from the body surfaces and chelicerae of <jats:italic>S. nobilis<\/jats:italic>, and two native spiders: <jats:italic>Amaurobius similis<\/jats:italic> and <jats:italic>Eratigena atrica<\/jats:italic>. Out of 22 bacterial species isolated from <jats:italic>S. nobilis<\/jats:italic>, 12 were related to human pathogenicity among which <jats:italic>Staphylococcus epidermidis<\/jats:italic>, <jats:italic>Kluyvera intermedia<\/jats:italic>, <jats:italic>Rothia mucilaginosa<\/jats:italic> and <jats:italic>Pseudomonas putida<\/jats:italic> are recognized as class 2 pathogens. The isolates varied in their antibiotic susceptibility: <jats:italic>Pseudomonas putida, Staphylococcus capitis<\/jats:italic> and <jats:italic>Staphylococcus edaphicus<\/jats:italic> showed the highest extent of resistance, to three antibiotics in total. On the other hand, all bacteria recovered from <jats:italic>S<\/jats:italic>. <jats:italic>nobilis<\/jats:italic> were susceptible to ciprofloxacin. Our study demonstrates that <jats:italic>S. nobilis<\/jats:italic> does carry opportunistic pathogenic bacteria on its body surfaces and chelicerae. Therefore, some post-bite infections could be the result of vector-borne bacterial zoonoses that may be antibiotic resistant.<\/jats:p>","DOI":"10.1038\/s41598-020-77839-9","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T11:05:07Z","timestamp":1606820707000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Synanthropic spiders, including the global invasive noble false widow Steatoda nobilis, are reservoirs for medically important and antibiotic resistant bacteria"],"prefix":"10.1038","volume":"10","author":[{"given":"John P.","family":"Dunbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neyaz A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy L.","family":"Abberton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearce","family":"Brosnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Afoullouss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"O\u2019Flaherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel M.","family":"Dugon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"77839_CR1","doi-asserted-by":"publisher","first-page":"e0007169","DOI":"10.1371\/journal.pntd.0007169","volume":"13","author":"CV Pulford","year":"2019","unstructured":"Pulford, C. 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