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In <jats:italic>Caenorhabditis elegans,<\/jats:italic> two <jats:italic>cbs<\/jats:italic> genes are present: <jats:italic>cbs-1<\/jats:italic> functions similarly as to human CBS, and <jats:italic>cbs-2,<\/jats:italic> whose roles are instead unknown. In the present study we performed a phenotypic characterization of the <jats:italic>cbs-2<\/jats:italic> mutant. The null <jats:italic>cbs-2<\/jats:italic> mutant is viable, fertile and shows the wild-type complement of six bivalents in most oocyte nuclei, which is indicative of a correct formation of crossover recombination. In absence of synaptonemal complex formation (<jats:italic>syp-2<\/jats:italic> mutant), loss of <jats:italic>cbs-2<\/jats:italic> leads to chromosome fragmentation, suggesting that <jats:italic>cbs-2<\/jats:italic> is essential during inter-sister repair. Interestingly, although proficient in the activation of the DNA damage checkpoint after exposure to genotoxic stress, the <jats:italic>cbs-2<\/jats:italic> mutant is defective in DNA damage-induced apoptosis in meiotic germ cells. These results suggest possible functions for CBS-2 in meiosis, distinct from a role in the trans-sulfuration pathway. We propose that the <jats:italic>C. elegans<\/jats:italic> CBS-2 protein is required for both inter-sister repair and execution of DNA damage-induced apoptosis.<\/jats:p>","DOI":"10.1038\/s41598-020-78006-w","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T11:05:07Z","timestamp":1606820707000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Functional characterization of Caenorhabditis elegans cbs-2 gene during meiosis"],"prefix":"10.1038","volume":"10","author":[{"given":"Pamela","family":"Santonicola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Germoglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico Scotto","family":"d\u2019Abbusco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adele","family":"Adamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"78006_CR1","doi-asserted-by":"publisher","first-page":"22457","DOI":"10.1074\/jbc.M109.010868","volume":"284","author":"S Singh","year":"2009","unstructured":"Singh, S., Padovani, D., Leslie, R. 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