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Diabetic patients who were propensity-score matched were retrospectively included from hospital-based database. Kaplan\u2013Meier approach with a log-rank test was used to compare the cumulative incidences of KP-PLA including IKPS between aspirin users and non-users. Totally, 63,500 patients were analyzed after propensity-score matching (1:1). Compared with that of non-users, the incidence of KP-PLA was significantly reduced in aspirin users (0.31% vs. 0.50%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), but not for that of IKPS (0.02% vs. 0.03%, <jats:italic>p<\/jats:italic>\u2009=\u20090.29). Patients taking aspirin for\u2009\u2265\u200990\u00a0days had a significantly lower risk for KP-PLA (hazard ratio, 0.67; 95%CI, 0.50\u20130.90). Females, taking clopidogrel or metformin for\u2009\u2265\u200990\u00a0days, and taking H2-blockers or proton pump inhibitors (PPIs) for\u2009\u2265\u20095\u00a0days were also associated with a lower risk of KP-PLA. However, cholangitis and a glycated hemoglobin\u2009\u2265\u20098.5% were associated with an\u00a0increased risk of KP-PLA.<\/jats:p>","DOI":"10.1038\/s41598-020-78442-8","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T11:07:06Z","timestamp":1607339226000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The impact of aspirin on Klebsiella pneumoniae liver abscess in diabetic patients"],"prefix":"10.1038","volume":"10","author":[{"given":"Chien-Hsiang","family":"Tai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ning","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Cheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Kun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chen","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng-Kee","family":"Chuah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hsiang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"78442_CR1","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.jmii.2014.08.028","volume":"49","author":"YC Chen","year":"2016","unstructured":"Chen, Y. 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