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In Australia, two remarkably similar mortality events enabled the creation of a case definition based on pathology and environmental factors. The first affected a community of endemic<jats:italic>Tursiops australis<\/jats:italic>in the Gippsland Lakes, Victoria, while the second occurred among<jats:italic>T. aduncus<\/jats:italic>resident in the Swan-Canning River system, Western Australia. The common features of both events were (1) an abrupt and marked decrease in salinity (from\u2009&gt;\u200930ppt to\u2009&lt;\u20095ppt) due to rainfall in the catchments, with hypo-salinity persisting weeks to months, and (2) dermatitis characterized grossly by patchy skin pallor that progressed to variable circular or targetoid, often raised, and centrally ulcerated lesions covering up to 70% of the body surface. The affected skin was often colonized by a variety of fungal, bacterial and algal species that imparted variable yellow, green or orange discoloration. Histologic lesions consisted of epidermal hydropic change leading to vesiculation and erosion; alternately, or in addition, the formation of intra-epithelial pustules resulting in ulceration and hypodermal necrosis. Thus, the environmental factors and characteristic pathologic lesions, are necessary components of the case definition for freshwater skin disease.<\/jats:p>","DOI":"10.1038\/s41598-020-78858-2","type":"journal-article","created":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T11:04:54Z","timestamp":1608030294000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Fresh water skin disease in dolphins: a case definition based on pathology and environmental factors in Australia"],"prefix":"10.1038","volume":"10","author":[{"given":"P\u00e1draig J.","family":"Duignan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahiid S.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Robb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,15]]},"reference":[{"key":"78858_CR1","first-page":"399","volume":"43","author":"JR Geraci","year":"1979","unstructured":"Geraci, J. 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