{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:53:16Z","timestamp":1787003596162,"version":"build-2736575974"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Supra inguinal fascia iliaca compartment block (FICB) is increasingly used in elderly patients with hip fractures. However, the minimum effective volume of local anesthetics required for ultrasound-guided supra-inguinal FICB has not been determined. With ethical committee approval and written informed consent from patients, we studied 21 consecutive patients of ASA physical status I\u2013III undergoing surgery for hip fracture who met the inclusion criteria. Blocks were performed before going to the operation room. We determined the injection volumes of 0.25% ropivacaine for consecutive patients from the preceding patient's outcome. The initial volume was 30\u00a0ml. The testing interval was set at 10\u00a0ml, and the lowest volume was 5\u00a0ml. An effective block was defined as loss of sensation of pinprick in the territory of the femoral nerve and lateral cutaneous nerve of the thigh 30\u00a0min after the injection. The aim of this study was to determine the 50% effective volume (EV\n                    <jats:sub>50<\/jats:sub>\n                    ) and the 95% effective volume (EV\n                    <jats:sub>95<\/jats:sub>\n                    ) of 0.25% ropivacaine for ultrasound-guided supra-inguinal FICB using Logistic regression analysis. EV\n                    <jats:sub>50<\/jats:sub>\n                    and EV\n                    <jats:sub>95<\/jats:sub>\n                    of 0.25% ropivacaine for ultrasound-guided supra-inguinal FICB calculated with logistic regression analysis were 15.01\u00a0ml (95% confidence interval, 6.53\u201322.99\u00a0ml) and 26.99\u00a0ml (95% confidence interval, 20.54\u201384.09\u00a0ml), respectively. EV\n                    <jats:sub>50<\/jats:sub>\n                    and EV\n                    <jats:sub>95<\/jats:sub>\n                    of 0.25% ropivacaine for ultrasound-guided supra-inguinal FICB were 15.01\u00a0ml and 26.99\u00a0ml, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical trial number<\/jats:bold>\n                    : UMIN000027277 (URL\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.umin.ac.jp\/ctr\/index-j.htm\">https:\/\/www.umin.ac.jp\/ctr\/index-j.htm<\/jats:ext-link>\n                    ).\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-79059-7","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T06:04:43Z","timestamp":1607925883000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Minimum effective volume of ropivacaine for ultrasound-guided supra-inguinal fascia iliaca compartment block"],"prefix":"10.1038","volume":"10","author":[{"given":"Kumiko","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Inomata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyuki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"key":"79059_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1017\/cem.2015.75","volume":"18","author":"B Ritcey","year":"2016","unstructured":"Ritcey, B., Pageau, P., Woo, M. Y. & Perry, J. J. Regional nerve blocks for hip and femoral neck fractures in the emergency department: A systematic review. CJEM. 18, 37\u201347 (2016).","journal-title":"CJEM."},{"key":"79059_CR2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.injury.2015.08.014","volume":"46","author":"TH Tosounidis","year":"2015","unstructured":"Tosounidis, T. H., Sheikh, H., Stone, M. H. & Giannoudis, P. V. Pain relief management following proximal femoral fractures: Options, issues and controversies. Injury 46, 52\u201358 (2015).","journal-title":"Injury"},{"key":"79059_CR3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.mporth.2016.03.012","volume":"30","author":"N Freeman","year":"2016","unstructured":"Freeman, N. & Clarke, J. Perioperative pain management for hip fracture patients. J. Orthop. Trauma. 30, 145\u2013152 (2016).","journal-title":"J. Orthop. 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