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The WHO describes an increasing global health burden with more than 290 million people threatened by the disease and a potential to spread into regions with temperate climates like Corsica, France. The aim of our study was to investigate the influence of <jats:italic>S. mansoni<\/jats:italic> infection on colorectal carcinogenic signaling pathways in vivo and in vitro. <jats:italic>S. mansoni<\/jats:italic> infection, soluble egg antigens (SEA) and the Interleukin-4-inducing principle from <jats:italic>S. mansoni<\/jats:italic> eggs induce Wnt\/\u03b2-catenin signaling and the protooncogene c-Jun as well as downstream factor Cyclin D1 and markers for DNA-damage, such as Parp1 and \u03b3H2a.x in enterocytes. The presence of these characteristic hallmarks of colorectal carcinogenesis was confirmed in colon biopsies from <jats:italic>S. mansoni<\/jats:italic>-infected patients demonstrating the clinical relevance of our findings. 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