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To prolong their survival, helminths suppress the immune responses of their hosts.\n                    <jats:italic>Strongyloides ratti<\/jats:italic>\n                    delays its expulsion from the gut by induction of regulatory circuits in a mouse strain-specific manner: depletion of Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    regulatory T cells (Treg) improves the anti-\n                    <jats:italic>S. ratti<\/jats:italic>\n                    immunity in BALB\/c but not in C57BL\/6 mice. In the current study we compare the hierarchy of immunoregulatory pathways in BALB\/c, C57BL\/6 mice and their F1 progeny (BALB\/c \u00d7 C57BL\/6). Using multicolor flow cytometry, we show that\n                    <jats:italic>S<\/jats:italic>\n                    .\n                    <jats:italic>ratti<\/jats:italic>\n                    induces a distinct pattern of inhibitory checkpoint receptors by Foxp3\n                    <jats:sup>+<\/jats:sup>\n                    Treg and Foxp3\n                    <jats:sup>\u2212<\/jats:sup>\n                    T cells. Intensity of expression was highest in C57BL\/6 and lowest in BALB\/c mice, while the F1 cross had an intermediate phenotype or resembled BALB\/c mice. Treg subsets expanded during infection in all three mouse strains. Similar to BALB\/c mice, depletion of Treg reduced intestinal parasite burden and increased mucosal mast cell activation in\n                    <jats:italic>S. ratti<\/jats:italic>\n                    -infected F1 mice. Our data indicate that Treg dominate the regulation of immune responses in BALB\/c and F1 mice, while multiple regulatory layers exist in C57BL\/6 mice that may compensate for the absence of Treg.\n                  <\/jats:p>","DOI":"10.1038\/s41598-020-79477-7","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T06:02:30Z","timestamp":1610690550000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Elucidating different pattern of immunoregulation in BALB\/c and C57BL\/6 mice and their F1 progeny"],"prefix":"10.1038","volume":"11","author":[{"given":"Wiebke","family":"Hartmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birte","family":"Blankenhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Luise","family":"Brunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Meiners","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minka","family":"Breloer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"79477_CR1","doi-asserted-by":"publisher","first-page":"8636","DOI":"10.1038\/s41598-018-26907-2","volume":"8","author":"M Reitz","year":"2018","unstructured":"Reitz, M. et al. 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