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In this paper we have evaluated the activity of commercially available thyme oil and its constituents thymol, carvacrol, and<jats:italic>p<\/jats:italic>-cymene, as potential disruptants of the pheromone-mediated communication in the major pest moths<jats:italic>Spodoptera littoralis<\/jats:italic>Boisduval (Lepidoptera: Noctuidae), and<jats:italic>Grapholita molesta<\/jats:italic>(Busck) (Lepidoptera: Tortricidae). In electroantennographic assays, the antennal response of males to thyme oil, thymol, and carvacrol was altered at high doses (10<jats:sup>3<\/jats:sup>\u201310<jats:sup>4<\/jats:sup>\u00a0\u00b5g), shifting the signal waveform into a biphasic negative\u2013positive potential that caused a decay in the response. In wind tunnel assays, pheromone-mediated attraction of males of both species was interrupted in presence of thyme oil. Further trials demonstrated that thymol alone reduced the number of<jats:italic>G. molesta<\/jats:italic>and<jats:italic>S. littoralis<\/jats:italic>males landing on the pheromone source. This effect did not differ from that of thyme oil, although the latter provoked a significant reduction on downwind behavior steps in<jats:italic>S. littoralis<\/jats:italic>. Overall, our findings provide a preliminary basis for delving into the effect of thyme oil, and especially of its major constituent thymol, as potential mating disruptants of both species.<\/jats:p>","DOI":"10.1038\/s41598-020-79550-1","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T11:15:21Z","timestamp":1610536521000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inhibitory effect of thymol on pheromone-mediated attraction in two pest moth species"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-1622","authenticated-orcid":false,"given":"Sergio","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aroa","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2323-2691","authenticated-orcid":false,"given":"\u00c1ngel","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-2778","authenticated-orcid":false,"given":"Carmen","family":"Quero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"79550_CR1","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.tplants.2016.10.005","volume":"21","author":"R Pavela","year":"2016","unstructured":"Pavela, R. & Benelli, G. 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