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SNEDDS of furosemide contained 10% Castor oil, 60% Cremophor EL, and 30% PEG 400. The mean droplets size was 17.9\u2009\u00b1\u20094.5\u00a0nm. The theoretical model was used to calculate the amounts of the carrier (Avicel PH101) and coating materials (Aerosil 200) to prepare liquisolid powder. Carrier\/coating materials ratio of 5\/1 was used and Ludipress was added to the solid system, thus tablets with hardness of 45\u2009\u00b1\u20092\u00a0N were obtained. Liquisolid tablets showed 2-folds increase in drug release as compared to the generic tablets after 60\u00a0min in HCl 0.1\u00a0N using USP apparatus-II. Furosemide loaded SNEDDS tablets have great prospects for further in vivo studies, and the theoretical model is useful for calculating the adequate amounts of adsorbents required to solidify these systems.<\/jats:p>","DOI":"10.1038\/s41598-020-79940-5","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T11:11:08Z","timestamp":1610622668000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Formulation and in vitro evaluation of self-nanoemulsifying liquisolid tablets of furosemide"],"prefix":"10.1038","volume":"11","author":[{"given":"Lena","family":"Dalal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Wahab","family":"Allaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hind","family":"El-Zein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,14]]},"reference":[{"key":"79940_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jconrel.2017.01.014","volume":"248","author":"R Ghadi","year":"2017","unstructured":"Ghadi, R. & Dand, N. 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