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This work studied the status of pentraxin (CRP\/SAP) protein, ferritin, TNF-\u03b1 and IL-1\u03b2 levels in Dengue patients of different pathophysiological manifestations. Accordingly, clinically confirmed Dengue cases (n\u2009=\u200997) were enrolled and subsequently blood parameters were studied by Haematology cell counter and Biochemistry Autoanalyser. CRP, SAP, ferritin, TNF-\u03b1 and IL-1\u03b2 ELISA were done in all the samples by using standard ELISA kits. Statistical Analysis was done in all the experiments. The levels of CRP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), SAP (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), ferritin (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), TNF-\u03b1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and IL-1\u03b2 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) were high in patients with Severe Dengue as compared to Dengue without warning signs. High levels of SGOT, SGPT and decreased platelet counts were found in severe patients as compared to Healthy donor. CRP\/SAP as well as TNF-\u03b1\/IL-1\u03b2 were independently associated with both dengue severity and overall disease manifestation. Statistically significant increased CRP, SAP, ferritin, TNF-\u03b1 and IL-1\u03b2 titres were correlated in patients with severe clinical manifestations as compared to mild disease forms of dengue. Elevated levels of pentraxin, TNF-\u03b1\/IL-1\u03b2 in blood during dengue infection could act as an early predictor in Severe Dengue infection.<\/jats:p>","DOI":"10.1038\/s41598-020-80144-0","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T18:36:08Z","timestamp":1610476568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Increased levels of pentraxins protein and cytokines bear good association in patients with severe dengue infection"],"prefix":"10.1038","volume":"11","author":[{"given":"Goutam","family":"Patra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bibhuti","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumi","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"80144_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0065-3527(08)60342-5","volume":"53","author":"DJ Gur","year":"1999","unstructured":"Gur, D. 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