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The study involved eighty-four individuals with chronic stroke (mean age\u2009=\u200959.7\u00a0years, SD\u2009=\u20096.5) with mild to moderate motor impairment (Fugl-Meyer Assessment lower limb motor score: mean\u2009=\u200924.0, SD\u2009=\u20093.5) randomly assigned to either a 20\u00a0Hz or 30\u00a0Hz WBV intervention program. Both programs involved 3 training sessions per week for 8\u00a0weeks. Isokinetic knee concentric and eccentric extension strength, serum level of cross-linked N-telopeptides of type I collagen (NTx), and walking endurance (6-min walk test; 6MWT) were assessed at baseline and post-intervention. An intention-to-treat analysis revealed a significant time effect for all muscle strength outcomes and NTx, but not for 6MWT. The time-by-group interaction was only significant for the paretic eccentric knee extensor work, with a medium effect size (0.44; 95% CI: 0.01, 0.87). Both WBV protocols were effective in improving leg muscle strength and reducing bone resorption. Comparatively greater improvement in paretic eccentric leg strength was observed for the 30\u00a0Hz protocol.<\/jats:p>","DOI":"10.1038\/s41598-020-80526-4","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T11:13:01Z","timestamp":1610104381000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of different vibration frequencies on muscle strength, bone turnover and walking endurance in chronic stroke"],"prefix":"10.1038","volume":"11","author":[{"given":"Zhenhui","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiev","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zou","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Y. 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