{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:58:43Z","timestamp":1793411923813,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Choroidal microvasculature dropout (CMvD) implies compromised optic nerve head perfusion in glaucoma patients. However, there are conflicting findings whether office-hour systemic blood pressure (BP) is related to the presence of CMvD. The present study investigated which systemic BP parameters, derived from 24-h ambulatory BP monitoring (ABPM), are associated with CMvD as assessed by optical coherence tomography angiography (OCT-A) in normal-tension glaucoma (NTG). This study included 88 eyes of 88 NTG patients who underwent 24-h ABPM and OCT-A imaging. Various systemic BP parameters associated with the presence of CMvD were evaluated using logistic regression analyses. CMvD was detected in 38 NTG eyes (43.2%). NTG eyes with CMvD had nighttime diastolic BP (DBP) dip of greater magnitude and longer duration than eyes without CMvD. In multivariate logistic regression, worse VF mean deviation (MD) (odds ratio [OR] 0.786; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), greater nighttime DBP dip \u201c%\u201d (OR 1.051; <jats:italic>P<\/jats:italic>\u2009=\u20090.034), and higher daytime peak IOP (OR 1.459; <jats:italic>P<\/jats:italic>\u2009=\u20090.013) were significantly associated with the presence of CMvD. Based on our findings that the eyes with CMvD are closely associated with having nighttime DBP dip, NTG patients with CMvD should be recommended to undergo 24-h ABPM.<\/jats:p>","DOI":"10.1038\/s41598-020-80705-3","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T11:19:34Z","timestamp":1610104774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma"],"prefix":"10.1038","volume":"11","author":[{"given":"Joong Won","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Hye","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Kyung","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hun Jae","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"issue":"11","key":"80705_CR1","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1016\/j.ophtha.2007.03.016","volume":"114","author":"MC Leske","year":"2007","unstructured":"Leske, M. C. et al. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology 114(11), 1965\u20131972 (2007).","journal-title":"Ophthalmology"},{"issue":"1","key":"80705_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ophtha.2007.03.017","volume":"115","author":"MC Leske","year":"2008","unstructured":"Leske, M. C. et al. Risk factors for incident open-angle glaucoma: The Barbados Eye Studies. Ophthalmology 115(1), 85\u201393 (2008).","journal-title":"Ophthalmology"},{"issue":"6","key":"80705_CR3","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1097\/00055735-199912000-00017","volume":"10","author":"SS Hayreh","year":"1999","unstructured":"Hayreh, S. S. Role of nocturnal arterial hypotension in the development of ocular manifestations of systemic arterial hypertension. Curr. Opin. Ophthalmol. 10(6), 474\u2013482 (1999).","journal-title":"Curr. Opin. Ophthalmol."},{"issue":"1","key":"80705_CR4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0161-6420(95)31053-6","volume":"102","author":"SL Graham","year":"1995","unstructured":"Graham, S. L. et al. Ambulatory blood pressure monitoring in glaucoma. Nocturnal Dip. Ophthalmol. 102(1), 61\u201369 (1995).","journal-title":"Nocturnal Dip. Ophthalmol."},{"issue":"1","key":"80705_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1023\/A:1006113109864","volume":"22","author":"N Collignon","year":"1998","unstructured":"Collignon, N., Dewe, W., Guillaume, S. & Collignon-Brach, J. Ambulatory blood pressure monitoring in glaucoma patients: The nocturnal systolic dip and its relationship with disease progression. Int. Ophthalmol. 22(1), 19\u201325 (1998).","journal-title":"Int. Ophthalmol."},{"issue":"4","key":"80705_CR6","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1007\/s10384-003-0071-6","volume":"48","author":"T Tokunaga","year":"2004","unstructured":"Tokunaga, T. et al. Association between nocturnal blood pressure reduction and progression of visual field defect in patients with primary open-angle glaucoma or normal-tension glaucoma. Jpn. J. Ophthalmol. 48(4), 380\u2013385 (2004).","journal-title":"Jpn. J. Ophthalmol."},{"issue":"10","key":"80705_CR7","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1016\/j.ophtha.2014.04.016","volume":"121","author":"ME Charlson","year":"2014","unstructured":"Charlson, M. E. et al. Nocturnal systemic hypotension increases the risk of glaucoma progression. Ophthalmology 121(10), 2004\u20132012 (2014).","journal-title":"Ophthalmology"},{"issue":"6","key":"80705_CR8","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.ophtha.2017.11.029","volume":"125","author":"JD Melgarejo","year":"2018","unstructured":"Melgarejo, J. D. et al. Glaucomatous optic neuropathy associated with nocturnal dip in blood pressure: Findings from the maracaibo aging study. Ophthalmology 125(6), 807\u2013814 (2018).","journal-title":"Ophthalmology"},{"issue":"7","key":"80705_CR9","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.ophtha.2019.03.001","volume":"126","author":"J Kwon","year":"2019","unstructured":"Kwon, J. et al. Baseline systolic versus diastolic blood pressure dip and subsequent visual field progression in normal-tension glaucoma. Ophthalmology 126(7), 967\u2013979 (2019).","journal-title":"Ophthalmology"},{"issue":"3","key":"80705_CR10","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.ajo.2015.05.034","volume":"160","author":"J Lee","year":"2015","unstructured":"Lee, J. et al. Relationship between daytime variability of blood pressure or ocular perfusion pressure and glaucomatous visual field progression. Am. J. Ophthalmol. 160(3), 522\u201337.e1 (2015).","journal-title":"Am. J. Ophthalmol."},{"issue":"11","key":"80705_CR11","doi-asserted-by":"publisher","first-page":"5266","DOI":"10.1167\/iovs.09-3716","volume":"50","author":"KR Sung","year":"2009","unstructured":"Sung, K. R. et al. Twenty-four hour ocular perfusion pressure fluctuation and risk of normal-tension glaucoma progression. Invest. Ophthalmol. Vis. Sci. 50(11), 5266\u20135274 (2009).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"80705_CR12","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.ophtha.2017.03.039","volume":"124","author":"EJ Lee","year":"2017","unstructured":"Lee, E. J., Lee, K. M., Lee, S. H. & Kim, T. W. Parapapillary choroidal microvasculature dropout in glaucoma: A comparison between optical coherence tomography angiography and indocyanine green angiography. Ophthalmology 124(8), 1209\u20131217 (2017).","journal-title":"Ophthalmology"},{"issue":"12","key":"80705_CR13","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1016\/j.ophtha.2016.09.002","volume":"123","author":"MH Suh","year":"2016","unstructured":"Suh, M. H. et al. Deep retinal layer microvasculature dropout detected by the optical coherence tomography angiography in glaucoma. Ophthalmology 123(12), 2509\u20132518 (2016).","journal-title":"Ophthalmology"},{"issue":"2","key":"80705_CR14","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/IJG.0000000000000859","volume":"27","author":"JW Shin","year":"2018","unstructured":"Shin, J. W., Kwon, J., Lee, J. & Kook, M. S. Choroidal microvasculature dropout is not associated with myopia, but is associated with glaucoma. J. Glaucoma 27(2), 189\u2013196 (2018).","journal-title":"J. Glaucoma"},{"issue":"4","key":"80705_CR15","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.ophtha.2017.10.036","volume":"125","author":"EJ Lee","year":"2018","unstructured":"Lee, E. J., Kim, T. W., Kim, J. A. & Kim, J. A. Central visual field damage and parapapillary choroidal microvasculature dropout in primary open-angle glaucoma. Ophthalmology 125(4), 588\u2013596 (2018).","journal-title":"Ophthalmology"},{"key":"80705_CR16","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ajo.2018.01.035","volume":"188","author":"J Kwon","year":"2018","unstructured":"Kwon, J., Shin, J. W., Lee, J. & Kook, M. S. Choroidal microvasculature dropout is associated with parafoveal visual field defects in glaucoma. Am. J. Ophthalmol. 188, 141\u2013154 (2018).","journal-title":"Am. J. Ophthalmol."},{"issue":"7","key":"80705_CR17","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.ophtha.2018.01.016","volume":"125","author":"HL Park","year":"2018","unstructured":"Park, H. L., Kim, J. W. & Park, C. K. Choroidal microvasculature dropout is associated with progressive retinal nerve fiber layer thinning in glaucoma with disc hemorrhage. Ophthalmology 125(7), 1003\u20131013 (2018).","journal-title":"Ophthalmology"},{"key":"80705_CR18","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ajo.2018.12.007","volume":"200","author":"JM Kwon","year":"2019","unstructured":"Kwon, J. M., Weinreb, R. N., Zangwill, L. M. & Suh, M. H. Parapapillary deep-layer microvasculature dropout and visual field progression in glaucoma. Am. J. Ophthalmol. 200, 65\u201375 (2019).","journal-title":"Am. J. Ophthalmol."},{"issue":"3","key":"80705_CR19","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1167\/iovs.03-0469","volume":"45","author":"SS Hayreh","year":"2004","unstructured":"Hayreh, S. S. Posterior ciliary artery circulation in health and disease: The Weisenfeld lecture. Invest. Ophthalmol. Vis. Sci. 45(3), 749\u2013757 (2004).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"80705_CR20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0002-9394(76)90414-1","volume":"82","author":"DR Anderson","year":"1976","unstructured":"Anderson, D. R. & Braverman, S. Reevaluation of the optic disk vasculature. Am. J. Ophthalmol. 82(2), 165\u2013174 (1976).","journal-title":"Am. J. Ophthalmol."},{"issue":"5","key":"80705_CR21","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1167\/iovs.17-23046","volume":"59","author":"MH Suh","year":"2018","unstructured":"Suh, M. H. et al. Deep-layer microvasculature dropout by optical coherence tomography angiography and microstructure of parapapillary atrophy. Invest. Ophthalmol. Vis. Sci. 59(5), 1995\u20132004 (2018).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"5","key":"80705_CR22","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/S0002-9394(14)70067-4","volume":"117","author":"SS Hayreh","year":"1994","unstructured":"Hayreh, S. S., Zimmerman, M. B., Podhajsky, P. & Alward, W. L. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am. J. Ophthalmol. 117(5), 603\u2013624 (1994).","journal-title":"Am. J. Ophthalmol."},{"issue":"Suppl 1","key":"80705_CR23","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/S0039-6257(99)00016-8","volume":"43","author":"SL Graham","year":"1999","unstructured":"Graham, S. L. & Drance, S. M. Nocturnal hypotension: Role in glaucoma progression. Surv. Ophthalmol. 43(Suppl 1), S10\u2013S16 (1999).","journal-title":"Surv. Ophthalmol."},{"issue":"1","key":"80705_CR24","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1007\/s12028-013-9913-3","volume":"20","author":"GV Varsos","year":"2014","unstructured":"Varsos, G. V. et al. Cessation of diastolic cerebral blood flow velocity: The role of critical closing pressure. Neurocrit. Care 20(1), 40\u201348 (2014).","journal-title":"Neurocrit. Care"},{"issue":"5","key":"80705_CR25","doi-asserted-by":"publisher","first-page":"H2450","DOI":"10.1152\/ajpheart.00790.2004","volume":"288","author":"DS Fokkema","year":"2005","unstructured":"Fokkema, D. S. et al. Diastolic time fraction as a determinant of subendocardial perfusion. Am. J. Physiol. Heart Circ. Physiol. 288(5), H2450\u2013H2456 (2005).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"16","key":"80705_CR26","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.jacc.2016.07.754","volume":"68","author":"JW McEvoy","year":"2016","unstructured":"McEvoy, J. W. et al. Diastolic blood pressure, subclinical myocardial damage, and cardiac events: Implications for blood pressure control. J. Am. Coll. Cardiol. 68(16), 1713\u20131722 (2016).","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"80705_CR27","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1161\/HYPERTENSIONAHA.107.089797","volume":"50","author":"AD Protogerou","year":"2007","unstructured":"Protogerou, A. D. et al. Diastolic blood pressure and mortality in the elderly with cardiovascular disease. Hypertension 50(1), 172\u2013180 (2007).","journal-title":"Hypertension"},{"issue":"3","key":"80705_CR28","doi-asserted-by":"publisher","first-page":"345","DOI":"10.5603\/CJ.a2017.0109","volume":"25","author":"V Senthong","year":"2018","unstructured":"Senthong, V. et al. Low diastolic blood pressure is associated with a high atherosclerotic burden in patients with obstructive coronary artery disease. Cardiol. J. 25(3), 345\u2013352 (2018).","journal-title":"Cardiol. J."},{"issue":"6","key":"80705_CR29","doi-asserted-by":"publisher","first-page":"R278","DOI":"10.1186\/cc13133","volume":"17","author":"M Legrand","year":"2013","unstructured":"Legrand, M. et al. Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: A retrospective observational study. Crit. Care 17(6), R278 (2013).","journal-title":"Crit. Care"},{"key":"80705_CR30","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13054-016-1253-1","volume":"20","author":"S Saito","year":"2016","unstructured":"Saito, S. et al. Postoperative blood pressure deficit and acute kidney injury progression in vasopressor-dependent cardiovascular surgery patients. Crit. Care 20, 74 (2016).","journal-title":"Crit. Care"},{"issue":"1","key":"80705_CR31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13054-017-1611-7","volume":"21","author":"R Sato","year":"2017","unstructured":"Sato, R., Luthe, S. K. & Nasu, M. Blood pressure and acute kidney injury. Crit. Care 21(1), 28 (2017).","journal-title":"Crit. Care"},{"key":"80705_CR32","first-page":"592","volume":"103","author":"GA Cioffi","year":"2005","unstructured":"Cioffi, G. A. Ischemic model of optic nerve injury. Trans. Am. Ophthalmol. Soc. 103, 592\u2013613 (2005).","journal-title":"Trans. Am. Ophthalmol. Soc."},{"issue":"1","key":"80705_CR33","doi-asserted-by":"publisher","first-page":"8525","DOI":"10.1038\/s41598-019-44942-5","volume":"9","author":"YH Jo","year":"2019","unstructured":"Jo, Y. H. et al. Rapid central visual field progression rate in eyes with open-angle glaucoma and choroidal microvasculature dropout. Sci. Rep. 9(1), 8525 (2019).","journal-title":"Sci. Rep."},{"issue":"5","key":"80705_CR34","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S1350-9462(01)00004-0","volume":"20","author":"SS Hayreh","year":"2001","unstructured":"Hayreh, S. S. The blood supply of the optic nerve head and the evaluation of it\u2014myth and reality. Prog. Retin. Eye Res. 20(5), 563\u2013593 (2001).","journal-title":"Prog. Retin. Eye Res."},{"issue":"9","key":"80705_CR35","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1016\/S0161-6420(89)32721-7","volume":"96","author":"A Crichton","year":"1989","unstructured":"Crichton, A., Drance, S. M., Douglas, G. R. & Schulzer, M. Unequal intraocular pressure and its relation to asymmetric visual field defects in low-tension glaucoma. Ophthalmology 96(9), 1312\u20131314 (1989).","journal-title":"Ophthalmology"},{"issue":"4","key":"80705_CR36","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.ophtha.2015.11.020","volume":"123","author":"CG De Moraes","year":"2016","unstructured":"De Moraes, C. G. et al. Visual field change and 24-hour IOP-related profile with a contact lens sensor in treated glaucoma patients. Ophthalmology 123(4), 744\u2013753 (2016).","journal-title":"Ophthalmology"},{"issue":"1","key":"80705_CR37","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1089\/jop.2011.0081","volume":"28","author":"AG Konstas","year":"2012","unstructured":"Konstas, A. G. et al. Peak intraocular pressure and glaucomatous progression in primary open-angle glaucoma. J. Ocul. Pharmacol. Ther. 28(1), 26\u201332 (2012).","journal-title":"J. Ocul. Pharmacol. Ther."},{"issue":"9","key":"80705_CR38","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1016\/j.ophtha.2011.02.013","volume":"118","author":"SC Park","year":"2011","unstructured":"Park, S. C. et al. Initial parafoveal versus peripheral scotomas in glaucoma: Risk factors and visual field characteristics. Ophthalmology 118(9), 1782\u20131789 (2011).","journal-title":"Ophthalmology"},{"issue":"4","key":"80705_CR39","doi-asserted-by":"publisher","first-page":"504","DOI":"10.3109\/08820538.2015.1123733","volume":"32","author":"SW Jin","year":"2017","unstructured":"Jin, S. W., Seo, H. R., Rho, S. S. & Rho, S. H. The effects of nocturnal dip and blood pressure variability on paracentral scotoma in early open-angle glaucoma. Semin. Ophthalmol. 32(4), 504\u2013510 (2017).","journal-title":"Semin. Ophthalmol."},{"key":"80705_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2012.08.003","volume":"32","author":"DC Hood","year":"2013","unstructured":"Hood, D. C. et al. Glaucomatous damage of the macula. Prog. Retin. Eye Res. 32, 1\u201321 (2013).","journal-title":"Prog. Retin. Eye Res."},{"key":"80705_CR41","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ajo.2017.06.028","volume":"181","author":"PK Sodhi","year":"2017","unstructured":"Sodhi, P. K., Garg, E. & Vidula, ,. Association between nocturnal blood pressure dips and optic disc hemorrhage in patients with normal-tension glaucoma. Am. J. Ophthalmol. 181, 176\u2013177 (2017).","journal-title":"Am. J. Ophthalmol."},{"issue":"6","key":"80705_CR42","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1001\/jamaophthalmol.2019.0422","volume":"137","author":"HY Park","year":"2019","unstructured":"Park, H. Y., Shin, D. Y., Jeon, S. J. & Park, C. K. Association between parapapillary choroidal vessel density measured with optical coherence tomography angiography and future visual field progression in patients with glaucoma. JAMA Ophthalmol. 137(6), 681\u2013688 (2019).","journal-title":"JAMA Ophthalmol."},{"issue":"4","key":"80705_CR43","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","volume":"21","author":"J Flammer","year":"2002","unstructured":"Flammer, J. et al. The impact of ocular blood flow in glaucoma. Prog. Retin. Eye. Res. 21(4), 359\u2013393 (2002).","journal-title":"Prog. Retin. Eye. Res."},{"issue":"6","key":"80705_CR44","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1016\/j.ophtha.2010.10.016","volume":"118","author":"CS Kim","year":"2011","unstructured":"Kim, C. S., Seong, G. J., Lee, N. H. & Song, K. C. Prevalence of primary open-angle glaucoma in central South Korea the Namil study. Ophthalmology 118(6), 1024\u20131030 (2011).","journal-title":"Ophthalmology"},{"issue":"5","key":"80705_CR45","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.ajo.2012.11.020","volume":"155","author":"JM Kim","year":"2013","unstructured":"Kim, J. M. et al. Comparison of clinical characteristics between Korean and Western normal-tension glaucoma patients. Am. J. Ophthalmol. 155(5), 852\u2013857 (2013).","journal-title":"Am. J. Ophthalmol."},{"key":"80705_CR46","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.ajo.2017.01.002","volume":"176","author":"J Kwon","year":"2017","unstructured":"Kwon, J. et al. Association between nocturnal blood pressure dips and optic disc hemorrhage in patients with normal-tension glaucoma. Am. J. Ophthalmol. 176, 87\u2013101 (2017).","journal-title":"Am. J. Ophthalmol."},{"issue":"4","key":"80705_CR47","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1167\/iovs.13-13607","volume":"55","author":"DW Jeong","year":"2014","unstructured":"Jeong, D. W. et al. Circadian pattern of intraocular pressure fluctuations in young myopic eyes with open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 55(4), 2148\u20132156 (2014).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"10","key":"80705_CR48","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1097\/00004872-199310000-00019","volume":"11","author":"A Frattola","year":"1993","unstructured":"Frattola, A. et al. Prognostic value of 24-hour blood pressure variability. J. Hypertens. 11(10), 1133\u20131137 (1993).","journal-title":"J. Hypertens."},{"issue":"9718","key":"80705_CR49","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/S0140-6736(10)60309-1","volume":"375","author":"PM Rothwell","year":"2010","unstructured":"Rothwell, P. M. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet 375(9718), 938\u2013948 (2010).","journal-title":"Lancet"},{"issue":"2","key":"80705_CR50","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.amjhyper.2006.07.017","volume":"20","author":"P Verdecchia","year":"2007","unstructured":"Verdecchia, P. et al. Impact of blood pressure variability on cardiac and cerebrovascular complications in hypertension. Am. J. Hypertens. 20(2), 154\u2013161 (2007).","journal-title":"Am. J. Hypertens."},{"issue":"10","key":"80705_CR51","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.amjhyper.2006.03.009","volume":"19","author":"SD Pierdomenico","year":"2006","unstructured":"Pierdomenico, S. D. et al. Blood pressure variability and cardiovascular risk in treated hypertensive patients. Am. J. Hypertens. 19(10), 991\u2013997 (2006).","journal-title":"Am. J. Hypertens."},{"issue":"9","key":"80705_CR52","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1001\/archinte.1992.00400210081013","volume":"152","author":"P Palatini","year":"1992","unstructured":"Palatini, P. et al. Clinical relevance of nighttime blood pressure and of daytime blood pressure variability. Arch. Intern. Med. 152(9), 1855\u20131860 (1992).","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"80705_CR53","doi-asserted-by":"publisher","first-page":"4710","DOI":"10.1364\/OE.20.004710","volume":"20","author":"Y Jia","year":"2012","unstructured":"Jia, Y. et al. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography. Opt. Express 20(4), 4710\u20134725 (2012).","journal-title":"Opt. Express"},{"issue":"5","key":"80705_CR54","first-page":"908","volume":"30","author":"JB Jonas","year":"1989","unstructured":"Jonas, J. B., Nguyen, X. N., Gusek, G. C. & Naumann, G. O. Parapapillary chorioretinal atrophy in normal and glaucoma eyes. I. Morphometric data. Invest. Ophthalmol. Vis. Sci. 30(5), 908\u2013918 (1989).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"6","key":"80705_CR55","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/BF00175988","volume":"232","author":"AG Bennett","year":"1994","unstructured":"Bennett, A. G., Rudnicka, A. R. & Edgar, D. F. Improvements on Littmann\u2019s method of determining the size of retinal features by fundus photography. Graefes Arch. Clin. Exp. Ophthalmol. 232(6), 361\u2013367 (1994).","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"issue":"12","key":"80705_CR56","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3109\/02713683.2013.820328","volume":"38","author":"V Aykut","year":"2013","unstructured":"Aykut, V. et al. Influence of axial length on peripapillary retinal nerve fiber layer thickness in children: A study by RTVue spectral-domain optical coherence tomography. Curr. Eye Res. 38(12), 1241\u20131247 (2013).","journal-title":"Curr. Eye Res."},{"issue":"2","key":"80705_CR57","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.ophtha.2004.08.015","volume":"112","author":"P Mitchell","year":"2005","unstructured":"Mitchell, P. et al. Retinal vessel diameter and open-angle glaucoma: The Blue Mountains Eye Study. Ophthalmology 112(2), 245\u2013250 (2005).","journal-title":"Ophthalmology"},{"issue":"1","key":"80705_CR58","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1600-0587.2012.07348.x","volume":"36","author":"CF Dormann","year":"2013","unstructured":"Dormann, C. F. et al. Collinearity: A review of methods to deal with it and a simulation study evaluating their performance. Ecography 36(1), 27\u201346 (2013).","journal-title":"Ecography"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-80705-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-80705-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-80705-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T01:07:31Z","timestamp":1670029651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-020-80705-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,8]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["80705"],"URL":"https:\/\/doi.org\/10.1038\/s41598-020-80705-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,8]]},"assertion":[{"value":"12 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"206"}}