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We trained a 2D convolutional neural network (CNN) for automatic segmentation ventricular volume from 3D US of preterm infants with PHVD. The method was validated with the Dice similarity coefficient (DSC) and the intra-class coefficient (ICC) compared to manual segmentation. The mean birth weight of the included patients was 1233.1\u00a0g (SD 309.4) and mean gestational age was 28.1\u00a0weeks (SD 1.6). A total of 152 serial 3D US from 10 preterm infants with PHVD were analysed. 230 ventricles were manually segmented. Of these, 108 were used for training a 2D CNN and 122 for validating the methodology for automatic segmentation. The global agreement for manual versus automated measures in the validation data (n\u2009=\u2009122) was excellent with an ICC of 0.944 (0.874\u20130.971). The Dice similarity coefficient was 0.8 (\u00b1\u20090.01). 3D US based ventricular volume estimation through an automatic segmentation software developed through deep learning improves the accuracy and reduces the processing time needed for manual segmentation using VOCAL. 3D US should be considered a promising tool to help deepen our current understanding of the complex evolution of PHVD.<\/jats:p>","DOI":"10.1038\/s41598-020-80783-3","type":"journal-article","created":{"date-parts":[[2021,1,12]],"date-time":"2021-01-12T18:36:08Z","timestamp":1610476568000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Automatic segmentation of ventricular volume by 3D ultrasonography in post haemorrhagic ventricular dilatation among preterm infants"],"prefix":"10.1038","volume":"11","author":[{"given":"Lionel C.","family":"Gontard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Pizarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"Sanz-Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sim\u00f3n P.","family":"Lubi\u00e1n L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Benavente-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,12]]},"reference":[{"key":"80783_CR1","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3171\/2011.12.PEDS11136","volume":"9","author":"S Robinson","year":"2012","unstructured":"Robinson, S. 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