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We retrospectively reviewed 83 patients with histopathologically proven TETs (50 thymomas; 33 thymic carcinomas) who underwent FDG PET\/CT after surgery. The sensitivity and specificity of FDG PET\/CT in detecting recurrence were calculated. The progression-free survival rate (PFS) was calculated by the Kaplan\u2013Meier method. FDG PET\/CT results were positive in 50 patients and negative in 33. Recurrent TETs were confirmed in 40 of 50 patients with positive PET\/CT findings. The sensitivity and specificity of FDG PET\/CT were 100% and 76.7%, respectively. Disease progression occurred in 28 patients during the follow-up. FDG PET\/CT showed added prognostic value over the Masaoka stage and histopathology. Among patients with the same Masaoka stage, negative PET\/CT was significantly associated with better PFS (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Similarly, among patients with the same histopathology, negative PET\/CT was also associated with a significantly longer PFS (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). FDG PET\/CT demonstrated a good diagnostic performance in patients with recurrent TETs and had an important prognostic value in assessing the risk of disease progression.<\/jats:p>","DOI":"10.1038\/s41598-021-00003-4","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T15:30:38Z","timestamp":1634311838000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic and prognostic value of FDG PET-CT in patients with suspected recurrent thymic epithelial tumors"],"prefix":"10.1038","volume":"11","author":[{"given":"Guozhu","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuying","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"3_CR1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ejca.2007.11.004","volume":"44","author":"WK de Jong","year":"2008","unstructured":"de Jong, W. 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