{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:25:14Z","timestamp":1793053514517,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100016389","name":"Sociedad de Endocrinolog\u00eda, Nutrici\u00f3n y Diabetes de la Comunidad de Madrid","doi-asserted-by":"publisher","award":["BECA SENDIMAD de Ayuda a la Investigaci\u00f3n en Endocrinolog\u00eda, Nutrici\u00f3n y Diabetes 2019"],"award-info":[{"award-number":["BECA SENDIMAD de Ayuda a la Investigaci\u00f3n en Endocrinolog\u00eda, Nutrici\u00f3n y Diabetes 2019"]}],"id":[{"id":"10.13039\/501100016389","id-type":"DOI","asserted-by":"publisher"}]},{"name":"IRYCIS","award":["Convocatoria intramural de ayudas a proyectos de investigaci\u00f3n de investigadores noveles, investigadores cl\u00ednicos asociados y\/o grupos emergentes del Hospital Universitario Ram\u00f3n y Cajal 2019"],"award-info":[{"award-number":["Convocatoria intramural de ayudas a proyectos de investigaci\u00f3n de investigadores noveles, investigadores cl\u00ednicos asociados y\/o grupos emergentes del Hospital Universitario Ram\u00f3n y Cajal 2019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the diagnostic accuracy of the different tests commonly used in the evaluation of adrenal incidentalomas (AIs) for the identification of autonomous cortisol secretion (ACS) and comorbidities potentially related to ACS. In a retrospective study of patients with AIs\u2009\u2265\u20091\u00a0cm, we evaluated the diagnostic reliability and validity of the dexamethasone suppression test (DST), urinary free cortisol (UFC), ACTH, late-night salivary cortisol (LNSC), and dehydroepiandrosterone-sulphate (DHEAS) for the diagnosis of comorbidities potentially related to ACS. Diagnostic indexes were also calculated for UFC, ACTH, LNSC, and DHEAS considering DST as the gold standard test for the diagnosis of ACS, using three different post-DST cortisol thresholds (138\u00a0nmol\/L, 50\u00a0nmol\/L and 83\u00a0nmol\/L). We included 197 patients with AIs in whom the results of the five tests abovementioned were available. At diagnosis, 85.9% of patients with one or more AIs had any comorbidity potentially related to ACS, whereas 9.6% had ACS as defined by post-DST cortisol\u2009&gt;\u2009138\u00a0nmol\/L. The reliability of UFC, ACTH, LNSC, and DHEAS for the diagnosis of ACS was low (kappa index\u2009&lt;\u20090.30). Of them, LNSC reached the highest diagnosis accuracy for ACS identification (AUC\u2009=\u20090.696 [95% CI 0.626\u20130.759]). The diagnostic performances of these tests for comorbidities potentially related to ACS was poor; of them, the DST was the most accurate (AUC\u2009=\u20090.661 [95% CI 0.546\u20130.778]) and had the strongest association with these comorbidities (OR 2.6, <jats:italic>P<\/jats:italic>\u2009=\u20090.045). Patients presenting with increased values of both DST and LNSC had the strongest association with hypertension (OR 7.1, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and with cardiovascular events (OR 3.6, <jats:italic>P<\/jats:italic>\u2009=\u20090.041). In conclusion,\u00a0LNSC was the test showing the highest diagnosis accuracy for the identification of ACS when a positive DST was used as the gold standard for its diagnosis. The DST test showed the strongest association with comorbidities potentially related to ACS. The definition of ACS based on the combination of elevated DST and LNSC levels improved the identification of patients with increased cardiometabolic risk.\n<\/jats:p>","DOI":"10.1038\/s41598-021-00011-4","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T15:30:38Z","timestamp":1634311838000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Diagnostic accuracy of the different hormonal tests used for the diagnosis of autonomous cortisol secretion"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0519-0072","authenticated-orcid":false,"given":"Marta","family":"Araujo-Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garc\u00eda Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Jim\u00e9nez Mendiguch\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor F.","family":"Escobar-Morreale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Valderr\u00e1bano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"issue":"1","key":"11_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.beem.2011.08.006","volume":"26","author":"J Wagner","year":"2012","unstructured":"Wagner, J. & Aron, D. C. Incidentalomas\u2014A \u201cdisease\u201d of modern imaging technology. Best Pract Res. Clin. Endocrinol. Metab. 26(1), 3\u20138. https:\/\/doi.org\/10.1016\/j.beem.2011.08.006 (2012).","journal-title":"Best Pract Res. Clin. Endocrinol. Metab."},{"issue":"2","key":"11_CR2","doi-asserted-by":"publisher","first-page":"G1","DOI":"10.1530\/EJE-16-0467","volume":"175","author":"M Fassnacht","year":"2016","unstructured":"Fassnacht, M. et al. Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors. Eur. J. Endocrinol. 175(2), G1\u2013G34. https:\/\/doi.org\/10.1530\/EJE-16-0467 (2016).","journal-title":"Eur. J. Endocrinol."},{"issue":"4","key":"11_CR3","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1210\/edrv-16-4-460","volume":"16","author":"RT Kloos","year":"1995","unstructured":"Kloos, R. T., Gross, M. D., Francis, I. R., Korobkin, M. & Shapiro, B. Incidentally discovered adrenal masses. Endocr. Rev. 16(4), 460\u2013484. https:\/\/doi.org\/10.1210\/edrv-16-4-460 (1995).","journal-title":"Endocr. Rev."},{"issue":"6","key":"11_CR4","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.endinu.2020.03.002","volume":"67","author":"M Araujo-Castro","year":"2020","unstructured":"Araujo-Castro, M. et al. Practical guide on the initial evaluation, follow-up, and treatment of adrenal incidentalomas Adrenal Diseases Group of the Spanish Society of Endocrinology and Nutrition. Endocrinol. Diabetes Nutr. 67(6), 408\u2013419. https:\/\/doi.org\/10.1016\/j.endinu.2020.03.002 (2020).","journal-title":"Endocrinol. Diabetes Nutr."},{"issue":"3","key":"11_CR5","doi-asserted-by":"publisher","first-page":"101427","DOI":"10.1016\/j.beem.2020.101427","volume":"34","author":"S Cambos","year":"2020","unstructured":"Cambos, S. & Tabarin, A. Management of adrenal incidentalomas: Working through uncertainty. Best Pract. Res. Clin. Endocrinol. Metab. 34(3), 101427. https:\/\/doi.org\/10.1016\/j.beem.2020.101427 (2020).","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"3","key":"11_CR6","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1530\/eje.1.02110","volume":"154","author":"B Bulow","year":"2006","unstructured":"Bulow, B. et al. Adrenal incidentaloma\u2014Follow-up results from a Swedish prospective study. Eur. J. Endocrinol. 154(3), 419\u2013423. https:\/\/doi.org\/10.1530\/eje.1.02110 (2006).","journal-title":"Eur. J. Endocrinol."},{"issue":"6","key":"11_CR7","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1530\/EJE-10-1147","volume":"164","author":"M Terzolo","year":"2011","unstructured":"Terzolo, M. et al. AME position statement on adrenal incidentaloma. Eur. J. Endocrinol. 164(6), 851\u2013870. https:\/\/doi.org\/10.1530\/EJE-10-1147 (2011).","journal-title":"Eur. J. Endocrinol."},{"issue":"6","key":"11_CR8","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.ando.2008.09.003","volume":"69","author":"A Tabarin","year":"2008","unstructured":"Tabarin, A. et al. Exploration and management of adrenal incidentalomas. French Society of Endocrinology Consensus. Ann. Endocrinol. 69(6), 487\u2013500. https:\/\/doi.org\/10.1016\/j.ando.2008.09.003 (2008).","journal-title":"Ann. Endocrinol."},{"issue":"1","key":"11_CR9","doi-asserted-by":"publisher","first-page":"S13","DOI":"10.2337\/dc19-S002","volume":"42","author":"American Diabetes Association","year":"2019","unstructured":"American Diabetes Association. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2019. Diabetes Care 42(1), S13\u2013S28. https:\/\/doi.org\/10.2337\/dc19-S002 (2019).","journal-title":"Diabetes Care"},{"issue":"25","key":"11_CR10","doi-asserted-by":"publisher","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","volume":"106","author":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","year":"2002","unstructured":"National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106(25), 3143\u20133421 (2002).","journal-title":"Circulation"},{"issue":"12","key":"11_CR11","doi-asserted-by":"publisher","first-page":"4462","DOI":"10.1210\/jc.2014-3007","volume":"99","author":"M Debono","year":"2014","unstructured":"Debono, M. et al. Cortisol as a marker for increased mortality in patients with incidental adrenocortical adenomas. J. Clin. Endocrinol. Metab. 99(12), 4462\u20134470. https:\/\/doi.org\/10.1210\/jc.2014-3007 (2014).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"11_CR12","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/S2213-8587(13)70211-0","volume":"2","author":"G Di Dalmazi","year":"2014","unstructured":"Di Dalmazi, G. et al. Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing\u2019s syndrome: A 15-year retrospective study. Lancet Diabetes Endocrinol. 2(5), 396\u2013405. https:\/\/doi.org\/10.1016\/S2213-8587(13)70211-0 (2014).","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"5","key":"11_CR13","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1530\/EJE-17-098","volume":"178","author":"E Sbardella","year":"2018","unstructured":"Sbardella, E. et al. Cardiovascular features of possible autonomous cortisol secretion in patients with adrenal incidentalomas. Eur. J. Endocrinol. 178(5), 501\u2013511. https:\/\/doi.org\/10.1530\/EJE-17-098 (2018).","journal-title":"Eur. J. Endocrinol."},{"issue":"2","key":"11_CR14","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.1365-2265.2010.03794.x","volume":"73","author":"V Morelli","year":"2010","unstructured":"Morelli, V. et al. Subclinical hypercortisolism: Correlation between biochemical diagnostic criteria and clinical aspects. Clin. Endocrinol. (Oxf) 73(2), 161\u2013166. https:\/\/doi.org\/10.1111\/j.1365-2265.2010.03794.x (2010).","journal-title":"Clin. Endocrinol. (Oxf)"},{"issue":"1","key":"11_CR15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1530\/EJE-17-0047","volume":"177","author":"V Morelli","year":"2017","unstructured":"Morelli, V. et al. Cardiovascular events in patients with mild autonomous cortisol secretion: Analysis with artificial neural networks. Eur. J. Endocrinol. 177(1), 73\u201383. https:\/\/doi.org\/10.1530\/EJE-17-0047 (2017).","journal-title":"Eur. J. Endocrinol."},{"key":"11_CR16","doi-asserted-by":"publisher","first-page":"S2530","DOI":"10.1016\/j.endinu.2021.07.004","volume":"2","author":"M Araujo-Castro","year":"2021","unstructured":"Araujo-Castro, M. et al. Presurgical predictive factors of surgical remission in Cushing\u2019s disease. Study of 32 cases. Endocrinol. Diabetes Nutr. 2, S2530. https:\/\/doi.org\/10.1016\/j.endinu.2021.07.004 (2021).","journal-title":"Endocrinol. Diabetes Nutr."},{"issue":"4","key":"11_CR17","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1530\/EJE-11-1039","volume":"166","author":"G Di Dalmazi","year":"2012","unstructured":"Di Dalmazi, G. et al. Progressively increased patterns of subclinical cortisol hypersecretion in adrenal incidentalomas differently predict major metabolic and cardiovascular outcomes: A large cross-sectional study. Eur. J. Endocrinol. 166(4), 669\u2013677. https:\/\/doi.org\/10.1530\/EJE-11-1039 (2012).","journal-title":"Eur. J. Endocrinol."},{"issue":"3","key":"11_CR18","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1210\/jc.2013-3527","volume":"99","author":"V Morelli","year":"2014","unstructured":"Morelli, V. et al. Long-term follow-up in adrenal incidentalomas: An Italian multicenter study. J. Clin. Endocrinol. Metab. 99(3), 827\u2013834. https:\/\/doi.org\/10.1210\/jc.2013-3527 (2014).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"11_CR19","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1176\/ajp.141.12.1550","volume":"141","author":"AH Rosenbaum","year":"1984","unstructured":"Rosenbaum, A. H. et al. The dexamethasone suppression test in normal control subjects: Comparison of two assays and effect of age. Am. J. Psychiatry 141(12), 1550\u20131555. https:\/\/doi.org\/10.1176\/ajp.141.12.1550 (1984).","journal-title":"Am. J. Psychiatry"},{"issue":"9","key":"11_CR20","doi-asserted-by":"publisher","first-page":"3266","DOI":"10.1210\/jc.2008-0104","volume":"93","author":"JW Funder","year":"2008","unstructured":"Funder, J. W. et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: An endocrine society clinical practice guideline. J. Clin. Endocrinol Metab. 93(9), 3266\u20133281. https:\/\/doi.org\/10.1210\/jc.2008-0104 (2008).","journal-title":"J. Clin. Endocrinol Metab."},{"key":"11_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.maturitas.2018.12.002","volume":"121","author":"GI Sydney","year":"2019","unstructured":"Sydney, G. I., Ioakim, K. J. & Paschou, S. A. Insulin resistance and adrenal incidentalomas: A bidirectional relationship. Maturitas 121, 1\u20136. https:\/\/doi.org\/10.1016\/j.maturitas.2018.12.002 (2019).","journal-title":"Maturitas"},{"issue":"1","key":"11_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12020-019-01888-y","volume":"64","author":"M Araujo-Castro","year":"2019","unstructured":"Araujo-Castro, M., Sampedro N\u00fa\u00f1ez, M. A. & Marazuela, M. Autonomous cortisol secretion in adrenal incidentalomas. Endocrine 64(1), 1\u201313. https:\/\/doi.org\/10.1007\/s12020-019-01888-y (2019).","journal-title":"Endocrine"},{"issue":"2","key":"11_CR23","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s12020-014-0387-7","volume":"48","author":"S Yener","year":"2015","unstructured":"Yener, S., Yilmaz, H., Demir, T., Secil, M. & Comlekci, A. DHEAS for the prediction of subclinical Cushing\u2019s syndrome: Perplexing or advantageous? Endocrine 48(2), 669\u2013676. https:\/\/doi.org\/10.1007\/s12020-014-0387-7 (2015).","journal-title":"Endocrine"},{"issue":"9","key":"11_CR24","doi-asserted-by":"publisher","first-page":"3529","DOI":"10.1210\/JC.2015-1992","volume":"100","author":"G Di Dalmazi","year":"2015","unstructured":"Di Dalmazi, G. et al. Steroid profiling by LC-MS\/MS in nonsecreting and subclinical cortisol-secreting adrenocortical adenomas. J. Clin. Endocrinol. Metab. 100(9), 3529\u20133538. https:\/\/doi.org\/10.1210\/JC.2015-1992 (2015).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"11_CR25","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1177\/0004563217704738","volume":"54","author":"H Stoddart","year":"2017","unstructured":"Stoddart, H. Low dehydroepiandrosterone sulphate: a sensitive and specific test for the detection of subclinical hypercortisolism in adrenal incidentalomas. Clin. Biochem. 54(4), 511. https:\/\/doi.org\/10.1177\/0004563217704738 (2017).","journal-title":"Clin. Biochem."},{"issue":"7","key":"11_CR26","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1055\/s-2001-16234","volume":"33","author":"A Tanabe","year":"2001","unstructured":"Tanabe, A. et al. Autonomy of cortisol secretion in clinically silent adrenal incidentaloma. Horm. Metab. Res. 33(7), 444\u2013450. https:\/\/doi.org\/10.1055\/s-2001-16234 (2001).","journal-title":"Horm. Metab. Res."},{"issue":"5","key":"11_CR27","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1210\/jcem.81.5.8626824","volume":"81","author":"Z Bencsik","year":"1996","unstructured":"Bencsik, Z. et al. Low dehydroepiandrosterone sulfate (DHEA-S) level is not a good predictor of hormonal activity in nonselected patients with incidentally detected adrenal tumors. J. Clin. Endocrinol. Metab. 81(5), 1726\u20131729. https:\/\/doi.org\/10.1210\/jcem.81.5.8626824 (1996).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"11_CR28","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1210\/jc.2018-01029","volume":"104","author":"H Olsen","year":"2019","unstructured":"Olsen, H., Kjellbom, A., L\u00f6ndahl, M. & Lindgren, O. Suppressed ACTH is frequently unrelated to autonomous cortisol secretion in patients with adrenal incidentalomas. J. Clin. Endocrinol. Metab. 104(2), 506\u2013512. https:\/\/doi.org\/10.1210\/jc.2018-01029 (2019).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"11_CR29","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s40618-019-01104-8","volume":"42","author":"M Vieira-Correa","year":"2019","unstructured":"Vieira-Correa, M. et al. Saliva versus serum cortisol to identify subclinical hypercortisolism in adrenal incidentalomas: Simplicity versus accuracy. J. Endocrinol. Investig. 42(12), 1435\u20131442. https:\/\/doi.org\/10.1007\/s40618-019-01104-8 (2019).","journal-title":"J. Endocrinol. Investig."},{"issue":"6","key":"11_CR30","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1530\/EJE-17-0078","volume":"176","author":"G Ueland","year":"2017","unstructured":"Ueland, G. et al. Simultaneous assay of cortisol and dexamethasone improved diagnostic accuracy of the dexamethasone suppression test. Eur. J. Endocrinol. 176(6), 705\u2013713. https:\/\/doi.org\/10.1530\/EJE-17-0078 (2017).","journal-title":"Eur. J. Endocrinol."},{"issue":"8","key":"11_CR31","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s40618-020-01197-6","volume":"43","author":"F Ceccato","year":"2020","unstructured":"Ceccato, F. et al. Dexamethasone measurement during low-dose suppression test for suspected hypercortisolism: Threshold development with and validation. J. Endocrinol. Investig. 43(8), 1105\u20131113. https:\/\/doi.org\/10.1007\/s40618-020-01197-6 (2020).","journal-title":"J. Endocrinol. Investig."},{"issue":"5","key":"11_CR32","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1210\/jc.2008-0125","volume":"93","author":"LK Nieman","year":"2008","unstructured":"Nieman, L. K. et al. The diagnosis of cushing\u2019s syndrome: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 93(5), 1526\u20131540. https:\/\/doi.org\/10.1210\/jc.2008-0125 (2008).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"11_CR33","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1373\/clinchem.2016.255034","volume":"62","author":"JM Hawley","year":"2016","unstructured":"Hawley, J. M. et al. Serum cortisol: An up-to-date assessment of routine assay performance. Clin. Chem. 62(9), 1220\u20131229. https:\/\/doi.org\/10.1373\/clinchem.2016.255034 (2016).","journal-title":"Clin. Chem."},{"key":"11_CR34","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02544-6","author":"M Araujo-Castro","year":"2020","unstructured":"Araujo-Castro, M., Valderr\u00e1bano, P., Escobar-Morreale, H. F., Hanzu, F. A. & Casals, G. Urine steroid profile as a new promising tool for the evaluation of adrenal tumors. Literature review. Endocrine. https:\/\/doi.org\/10.1007\/s12020-020-02544-6 (2020).","journal-title":"Endocrine"},{"issue":"11","key":"11_CR35","doi-asserted-by":"publisher","first-page":"5519","DOI":"10.1210\/jc.2019-00365","volume":"104","author":"G Di Dalmazi","year":"2019","unstructured":"Di Dalmazi, G. et al. The steroid profile of adrenal incidentalomas: Subtyping subjects with high cardiovascular risk. J. Clin. Endocrinol. Metab. 104(11), 5519\u20135528. https:\/\/doi.org\/10.1210\/jc.2019-00365 (2019).","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-00011-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-00011-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-00011-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T16:38:36Z","timestamp":1670085516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-00011-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["11"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-00011-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,15]]},"assertion":[{"value":"13 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20539"}}