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A consecutive sample of 435 internal derangement patients was enrolled in the study. Clinical and MRI studies were used to establish the new classification system. A total of 747 joints were classified according to our staging system and received treatment according to the associated nonsurgical treatment protocol. The primary outcome variables were maximum voluntary mouth opening and visual analogue scale pain scores. The secondary outcome variable was joint sound. Statistical analysis of the differences between pretreatment and posttreatment measurements showed an increase in mouth opening throughout the study period (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 at 12\u00a0m posttreatment). Statistical analysis of the <jats:bold>VAS<\/jats:bold> scores showed a statistically significant decrease in all study groups during all study periods, with <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001 at 12\u00a0months posttreatment. Statistical analysis of <jats:bold>joint sounds<\/jats:bold> showed significant improvement during all study periods. The new classification system is a simple, &amp; reasonable including a detailed description of all the pathologic changes of the joint. The nonsurgical treatment protocol was Simple, effective and specific depending on the pathological changes in joint.<\/jats:p>","DOI":"10.1038\/s41598-021-00456-7","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T10:09:32Z","timestamp":1634897372000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Classification of temporomandibular joint internal derangement based on magnetic resonance imaging and clinical findings of 435 patients contributing to a nonsurgical treatment protocol"],"prefix":"10.1038","volume":"11","author":[{"given":"Ayman F.","family":"Hegab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam IAbd","family":"Al Hameed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled Said","family":"Karam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"456_CR1","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.tripleo.2011.04.021","volume":"112","author":"D Manfredini","year":"2011","unstructured":"Manfredini, D. et al. 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