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Myometrium was collected on days 15\u201316 of pregnancy from pigs fed a normal- (n\u2009=\u20094) or restricted-diet (n\u2009=\u20094) from conception until day 9th of pregnancy, and the transcriptomic profiles of the tissue were compared using Porcine (V2) Expression Microarrays 4\u2009\u00d7\u200944\u00a0K. In restricted diet-fed pigs, 1021 differentially expressed genes (DEGs) with fold change\u2009\u2265\u20091.5, <jats:italic>P<\/jats:italic>\u2009\u2264\u20090.05 were revealed, and 708 of them were up-regulated. Based on the count score, the top within GOs was GO cellular components \u201c<jats:italic>extracellular exosome<\/jats:italic>\u201d, and the top KEGG pathway was the metabolic pathway. Ten selected DEGs, i.e.<jats:italic> hydroxysteroid (17\u03b2) dehydrogenase 8<\/jats:italic>, <jats:italic>cyclooxygenase 2, prostaglandin F receptor<\/jats:italic>, <jats:italic>progesterone receptor membrane component 1<\/jats:italic>, <jats:italic>progesterone receptor membrane component 2<\/jats:italic>, <jats:italic>annexin A2<\/jats:italic>, <jats:italic>homeobox A10<\/jats:italic>, <jats:italic>S-phase cyclin A-associated protein in the ER<\/jats:italic>, <jats:italic>SRC proto-oncogene<\/jats:italic>, <jats:italic>non-receptor tyrosine kinase<\/jats:italic>, and <jats:italic>proliferating cell nuclear antigen<\/jats:italic> were conducted through qPCR to validate microarray data. In conclusion, dietary restriction during the peri-conceptional period causes alterations in the expression of genes encoding proteins involved i.a. in the endocrine activity of the myometrium, embryo-maternal interactions, and mechanisms regulating cell cycle and proliferation.<\/jats:p>","DOI":"10.1038\/s41598-021-00533-x","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T10:04:13Z","timestamp":1635329053000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nutritional restriction during the peri-conceptional period alters the myometrial transcriptome during the peri-implantation period"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1328-0190","authenticated-orcid":false,"given":"Ewa Monika","family":"Drzewiecka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0260-5199","authenticated-orcid":false,"given":"Wiktoria","family":"Kozlowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0661-130X","authenticated-orcid":false,"given":"Agata","family":"Zmijewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-8207","authenticated-orcid":false,"given":"Anita","family":"Franczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"533_CR1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.anireprosci.2012.01.015","volume":"130","author":"TP Fleming","year":"2012","unstructured":"Fleming, T. 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