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The objective of this study was to evaluate the influence of thyroid nodule size on the clinical diagnostic efficacy of SWE. A total of 356 thyroid nodules of 280 patients were divided into three groups according to size (Group A:\u2009\u2264\u20091\u00a0cm; Group B: 1\u20132\u00a0cm; Group C:\u2009\u2265\u20092\u00a0cm). SWE was used to measure the maximum Young's modulus (Emax) values of all thyroid nodules. Receiver operating characteristic (ROC) curves were drawn with pathological results as the gold standard. For all nodules, the optimal cutoff value of Emax in SWE for diagnosing malignant thyroid nodules was 36.2\u00a0kPa. The sensitivity and specificity were 76.5% and 78.4%, respectively. Groups A, B, and C had different optimal Emax cutoff values of 33.7\u00a0kPa, 37.7\u00a0kPa, and 55.1\u00a0kPa, respectively. The area under the ROC curve (AUC) values of Groups A, B, and C (0.844, 0.886, and 0.935, respectively) were all greater than the values for all lesions (0.830). The specificity values of Groups A, B, and C (86.4%, 82.6%, and 88.2%, respectively) were all increased, and the sensitivity values of Groups B and C (89.7% and 96.4%, respectively) were also increased compared with the values for all lesions. Thyroid nodule size affects the optimal Emax cutoff value of SWE. We suggest that different cutoff values be used to diagnose benign and malignant thyroid nodules\u00a0according to lesion size.<\/jats:p>","DOI":"10.1038\/s41598-021-01114-8","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T11:04:18Z","timestamp":1635937458000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules"],"prefix":"10.1038","volume":"11","author":[{"given":"Huizhan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2782-5865","authenticated-orcid":false,"given":"Chunsong","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwang","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"issue":"1","key":"1114_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen, B. R. et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26(1), 1\u2013133. https:\/\/doi.org\/10.1089\/thy.2015.0020 (2016).","journal-title":"Thyroid"},{"issue":"11","key":"1114_CR2","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1007\/s00330-012-2495-1","volume":"22","author":"KS Bhatia","year":"2012","unstructured":"Bhatia, K. S. et al. Shear wave elastography of thyroid nodules in routine clinical practice: Preliminary observations and utility for detecting malignancy. Eur. Radiol. 22(11), 2397\u20132406. https:\/\/doi.org\/10.1007\/s00330-012-2495-1 (2012).","journal-title":"Eur. Radiol."},{"issue":"1","key":"1114_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3233\/CH-180452","volume":"72","author":"HX Xu","year":"2019","unstructured":"Xu, H. X. et al. 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