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Here, the molecular mechanisms of muscle atrophy following SCI were investigated. The GSE45550 gene expression profile of control (before SCI) and experimental (14\u00a0days following SCI) groups, consisting of Sprague\u2013Dawley rat soleus muscle (n\u2009=\u20096 per group), was downloaded from the Gene Expression Omnibus database, and then differentially expressed gene (DEG) identification and Gene Ontology, pathway, pathway network, and gene signal network analyses were performed. A total of 925 differentially expressed genes, 149 biological processes, and 55 pathways were screened. In the pathway network analysis, the 10 most important pathways were citrate cycle (TCA cycle), pyruvate metabolism, MAPK signalling pathway, fatty acid degradation, propanoate metabolism, apoptosis, focal adhesion, synthesis and degradation of ketone bodies, Wnt signalling, and cancer pathways. In the gene signal network analysis, the 10 most important genes were\n                    <jats:italic>Acat1<\/jats:italic>\n                    ,\n                    <jats:italic>Acadvl<\/jats:italic>\n                    ,\n                    <jats:italic>Acaa2<\/jats:italic>\n                    ,\n                    <jats:italic>Hadhb<\/jats:italic>\n                    ,\n                    <jats:italic>Acss1<\/jats:italic>\n                    ,\n                    <jats:italic>Oxct1<\/jats:italic>\n                    ,\n                    <jats:italic>Hadha, Hadh<\/jats:italic>\n                    ,\n                    <jats:italic>Acaca<\/jats:italic>\n                    , and\n                    <jats:italic>Cpt1b<\/jats:italic>\n                    . Thus, we screened the key genes and pathways that may be involved in muscle atrophy after SCI and provided support for finding valuable markers for this disease.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-01302-6","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T06:02:38Z","timestamp":1636437758000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Bioinformatic analysis of the gene expression profile in muscle atrophy after spinal cord injury"],"prefix":"10.1038","volume":"11","author":[{"given":"Hui","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinju","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiquan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"1302_CR1","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1152\/jappl.1999.86.1.350","volume":"86","author":"MJ Castro","year":"1999","unstructured":"Castro, M. 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