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Intracranial pressure (ICP) elevation occurs 18\u201324\u00a0h after experimental stroke. This elevation is prevented by short-duration hypothermia spanning the time of reperfusion. We aimed to determine whether hypothermia-rewarming completed prior to reperfusion, also prevents ICP elevation 24\u00a0h post-stroke. Transient middle cerebral artery occlusion was performed on male outbred Wistar rats. Sixty-minute hypothermia to 33\u00a0\u00b0C, followed by rewarming was induced prior to reperfusion in one group, and after reperfusion in another group. Normothermia controls received identical anaesthesia protocols. \u0394ICP from pre-stroke to 24\u00a0h post-stroke was measured, and infarct volumes were calculated. Rewarming pre-reperfusion prevented ICP elevation (\u0394ICP\u2009=\u20090.3\u2009\u00b1\u20093.9\u00a0mmHg vs. normothermia \u0394ICP\u2009=\u20095.2\u2009\u00b1\u20092.1\u00a0mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and reduced infarct volume (pre-reperfusion\u2009=\u200978.6\u2009\u00b1\u200923.7 mm<jats:sup>3<\/jats:sup> vs. normothermia\u2009=\u2009125.1\u2009\u00b1\u200944.3 mm<jats:sup>3<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) 24\u00a0h post-stroke. There were no significant differences in \u0394ICP or infarct volumes between hypothermia groups rewarmed pre- or post-reperfusion. Hypothermia during reperfusion is not necessary for prevention of ICP rise or infarct volume reduction. Short-duration hypothermia may be an applicable early treatment strategy for stroke patients prior to- during-, and after reperfusion therapy.<\/jats:p>","DOI":"10.1038\/s41598-021-01838-7","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T11:06:37Z","timestamp":1637060797000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Short-duration hypothermia completed prior to reperfusion prevents intracranial pressure elevation following ischaemic stroke in rats"],"prefix":"10.1038","volume":"11","author":[{"given":"Daniel","family":"Omileke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Azarpeykan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Bothwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Pepperall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Beard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Coupland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adjanie","family":"Patabendige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Spratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"1838_CR1","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1161\/STROKEAHA.108.543769","volume":"40","author":"PS Vosler","year":"2009","unstructured":"Vosler, P. 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