{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:25:29Z","timestamp":1793507129084,"version":"4.5.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oral mucositis (OM) is one of the most frequent adverse events of high-dose conditioning chemotherapy with melphalan prior to autologous hematopoietic stem cell transplantation (AHSCT). It significantly reduces the patients\u2019 quality of life. One of the preventive strategies for OM is cryotherapy. We retrospectively analyzed whether commercially available ice-cream could prevent OM during the melphalan infusion. We retrospectively analyzed 74 patients after AHSCT to see whether there is any correlation between OM and cryotherapy (ice-cream), melphalan dose (140\u00a0mg\/m<jats:sup>2<\/jats:sup> or 200\u00a0mg\/m<jats:sup>2<\/jats:sup>). The incidence of OM in our study inversely correlated with cryotherapy in the form of ice-cream. Out of 74 patients receiving conditioning chemotherapy with high-dose melphalan, 52 received cryotherapy. Fifteen patients in the cryotherapy group (28.84%) developed OM, whereas 13 patients (59.09%) developed it in the group without cryotherapy. In a multiple linear regression test cryotherapy remained a significant protective\u00a0factor against\u00a0OM (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) We have also seen the relationship between melphalan dose with OM (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005). Cryotherapy in the form of ice-cream is associated with a lower rate of OM and, therefore, could potentially be used as a cost-effective, less burdensome, and easy to implement method in prevention of oral mucositis.<\/jats:p>","DOI":"10.1038\/s41598-021-02002-x","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T11:06:20Z","timestamp":1637233580000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Ice-cream used as cryotherapy during high-dose melphalan conditioning reduces oral mucositis after autologous hematopoietic stem cell transplantation"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7519-9507","authenticated-orcid":false,"given":"Marcin","family":"Jasi\u0144ski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9529-7684","authenticated-orcid":false,"given":"Martyna","family":"Maciejewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0017-1040","authenticated-orcid":false,"given":"Anna","family":"Brodziak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"G\u00f3rka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Skwierawska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6813-3331","authenticated-orcid":false,"given":"Wies\u0142aw W.","family":"J\u0119drzejczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Tomaszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz W.","family":"Basak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-7571","authenticated-orcid":false,"given":"Emilian","family":"Snarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"issue":"8","key":"2002_CR1","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1038\/bmt.2015.6","volume":"50","author":"A Sureda","year":"2015","unstructured":"Sureda, A. et al. Indications for allo- and auto-SCT for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2015. Bone Marrow Transpl 50(8), 1037\u20131056. https:\/\/doi.org\/10.1038\/bmt.2015.6 (2015).","journal-title":"Bone Marrow Transpl"},{"issue":"7","key":"2002_CR2","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/j.bbmt.2020.03.002","volume":"26","author":"AS Kanate","year":"2020","unstructured":"Kanate, A. S. et al. Indications for hematopoietic cell transplantation and immune effector cell therapy: guidelines from the American Society for transplantation and cellular therapy. Biol Blood Marrow Transp 26(7), 1247\u20131256. https:\/\/doi.org\/10.1016\/j.bbmt.2020.03.002 (2020).","journal-title":"Biol Blood Marrow Transp"},{"issue":"8","key":"2002_CR3","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.1200\/JCO.2001.19.8.2201","volume":"19","author":"ST Sonis","year":"2001","unstructured":"Sonis, S. T. et al. Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation. J Clin Oncol 19(8), 2201\u20132205. https:\/\/doi.org\/10.1200\/JCO.2001.19.8.2201 (2001).","journal-title":"J Clin Oncol"},{"issue":"2","key":"2002_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cden.2013.12.005","volume":"58","author":"RV Lalla","year":"2014","unstructured":"Lalla, R. V., Saunders, D. P. & Peterson, D. E. Chemotherapy or radiation-induced oral mucositis. Dent Clin North Am 58(2), 341\u2013349. https:\/\/doi.org\/10.1016\/j.cden.2013.12.005 (2014).","journal-title":"Dent Clin North Am"},{"issue":"1","key":"2002_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s005209900095","volume":"8","author":"LA Bellm","year":"2000","unstructured":"Bellm, L. A., Epstein, J. B., Rose-Ped, A., Martin, P. & Fuchs, H. J. Patient reports of complications of bone marrow transplantation. 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Cochrane Database Syst Rev 11, CD011990. https:\/\/doi.org\/10.1002\/14651858.CD011990.pub2 (2017).","journal-title":"Cochrane Database Syst Rev"},{"issue":"11","key":"2002_CR8","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1038\/sj.bmt.1705384","volume":"37","author":"K Lilleby","year":"2006","unstructured":"Lilleby, K. et al. A prospective, randomized study of cryotherapy during administration of high-dose melphalan to decrease the severity and duration of oral mucositis in patients with multiple myeloma undergoing autologous peripheral blood stem cell transplantation. Bone Marrow Transp 37(11), 1031\u20131035. https:\/\/doi.org\/10.1038\/sj.bmt.1705384 (2006).","journal-title":"Bone Marrow Transp"},{"issue":"2","key":"2002_CR9","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1177\/1078155215620920","volume":"23","author":"J Chen","year":"2017","unstructured":"Chen, J., Seabrook, J., Fulford, A. & Rajakumar, I. Icing oral mucositis: oral cryotherapy in multiple myeloma patients undergoing autologous hematopoietic stem cell transplant. J Oncol Pharm Pract 23(2), 116\u2013120. https:\/\/doi.org\/10.1177\/1078155215620920 (2017).","journal-title":"J Oncol Pharm Pract"},{"issue":"6","key":"2002_CR10","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1111\/j.1365-2702.2005.01128.x","volume":"14","author":"S Karagozoglu","year":"2005","unstructured":"Karagozoglu, S. & Filiz Ulusoy, M. Chemotherapy: the effect of oral cryotherapy on the development of mucositis. J Clin Nurs 14(6), 754\u2013765. https:\/\/doi.org\/10.1111\/j.1365-2702.2005.01128.x (2005).","journal-title":"J Clin Nurs"},{"issue":"4","key":"2002_CR11","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1080\/10428190400029957","volume":"46","author":"A Tartarone","year":"2005","unstructured":"Tartarone, A., Matera, R., Romano, G., Vigliotti, M. L. & Di Renzo, N. 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Systematic review of oral cryotherapy for the management of oral mucositis in cancer patients and clinical practice guidelines. Support Care Cancer 28(5), 2449\u20132456. https:\/\/doi.org\/10.1007\/s00520-019-05217-x (2020).","journal-title":"Support Care Cancer"},{"issue":"5","key":"2002_CR14","doi-asserted-by":"publisher","first-page":"e0128763","DOI":"10.1371\/journal.pone.0128763","volume":"10","author":"L Wang","year":"2015","unstructured":"Wang, L. et al. Efficacy of oral cryotherapy on oral mucositis prevention in patients with hematological malignancies undergoing hematopoietic stem cell transplantation: a meta-analysis of randomized controlled trials. PLoS ONE 10(5), e0128763. https:\/\/doi.org\/10.1371\/journal.pone.0128763 (2015).","journal-title":"PLoS ONE"},{"issue":"7","key":"2002_CR15","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1038\/sj.bmt.1705471","volume":"38","author":"ML Grazziutti","year":"2006","unstructured":"Grazziutti, M. L. et al. Oral mucositis in myeloma patients undergoing melphalan-based autologous stem cell transplantation: incidence, risk factors and a severity predictive model. 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