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Cine magnetic resonance imaging (MRI) may potentially improve the quantitative analysis of gastrointestinal motility; however, suitable CIPO detection parameters should be determined. Cine MRI was performed in seven patients with CIPO and 11 healthy controls. The logarithm of the Mahalanobis distance (x<jats:sub>1<\/jats:sub>) and distance variation per time (x<jats:sub>2<\/jats:sub>) were used as the original parameters to determine CIPO diagnostic thresholds. Furthermore, the correlation between cine MRI findings and CIPO severity was investigated. Threshold values of \u03b1\u2009=\u20091.10 and \u03b2\u2009=\u20090.15 for x<jats:sub>1<\/jats:sub> and x<jats:sub>2<\/jats:sub>, respectively, produced a CIPO diagnosis sensitivity of 1.00 (7\/7) and specificity of 0.82 (9\/11). The resulting error was 0.11 (2\/18). The two parameters were correlated (Pearson\u2019s correlation coefficient: \u2212\u00a00.52). Any of the intestinal tracts of patients with severe CIPO requiring home parenteral nutrition belonged to the region defined by x<jats:sub>1<\/jats:sub>\u2009\u2265\u20091.10 and x<jats:sub>2<\/jats:sub>\u2009\u2264\u20090.15. Cine MRI is effective for the quantitative evaluation of small intestinal motility and CIPO diagnosis when using the abovementioned parameters and can be useful for treatment decision-making. However, these parameters have a wide distribution in healthy volunteers; this may complicate the detection of other disorders.<\/jats:p>","DOI":"10.1038\/s41598-021-02268-1","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T11:02:47Z","timestamp":1637924567000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["New cine magnetic resonance imaging parameters for the differential diagnosis of chronic intestinal pseudo-obstruction"],"prefix":"10.1038","volume":"11","author":[{"given":"Hiroki","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ogihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzo","family":"Kawata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Hamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Terai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"2268_CR1","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1159\/000337528","volume":"86","author":"H Ohkubo","year":"2012","unstructured":"Ohkubo, H. et al. 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