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One or both eyes of each subject were imaged for a 3\u2009\u00d7\u20093\u00a0mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Their association with visual field (VF) parameters and retinal nerve fiber layer (RNFL) thickness were determined. Sixty-eight eyes of 51 PACG, 68 eyes of 48 NTG, and 68 eyes of 49 control subjects were cross-sectionally analyzed. NTG eyes had significantly lower global cpVD (52.369\u2009\u00b1\u20090.781%) compared with PACG eyes (55.389\u2009\u00b1\u20090.721%,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.004) that had comparable disease severity and average RNFL thickness. Multivariable analysis revealed that, for PACG and NTG eyes, decreased cpVD ([PACG] \u03b2\u2009=\u2009\u22124.242; CI: \u22128.120, \u22120.363 vs [NTG] \u03b2\u2009=\u2009\u22125.531; CI: \u22129.472, \u22121.590) and cpFD ([PACG] \u03b2\u2009=\u2009\u22128.894;CI: \u221211.925, \u22125.864 vs [NTG] \u03b2\u2009=\u2009\u221212.064; CI: \u221217.095, \u22126.932) were associated with decreased RNFL thickness (all\n                    <jats:italic>P<\/jats:italic>\n                    \u2009\u2264\u20090.032); with a stronger association between decrease cpFD and decreased RNFL thickness in NTG eyes (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.028). Decreased cpVD was associated with decrease mean deviation (MD) in NTG eyes (\u03b2\u2009=\u2009\u22120.707; CI: \u22121.090, \u22120.324;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009\u2264\u20090.001) and not associated with the visual field parameters in PACG eyes. Early NTG had lower global cpVD compared with early PACG, despite similar disease severity and average RNFL thickness.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-02296-x","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:53:32Z","timestamp":1638276812000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of optical coherence tomography angiography metrics in primary angle-closure glaucoma and normal-tension glaucoma"],"prefix":"10.1038","volume":"11","author":[{"given":"Ruyue","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Meng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol Y.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poemen P.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clement C.","family":"Tham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"issue":"18","key":"2296_CR1","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1001\/jama.2014.3192","volume":"311","author":"RN Weinreb","year":"2014","unstructured":"Weinreb, R. 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