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Forty-two patients with Class II malocclusion were included, and their maxillary quadrants were allocated into two groups: treatment with an active diode laser and a placebo group. In each group, the time taken to obtain Class I occlusion after 6\u00a0months, rate of movement, total displacement of the maxillary canine to Class I occlusion and pain were recorded. The time to reach Class I occlusion in the active laser group (2.46\u2009\u00b1\u20092.1\u00a0months) was not significantly different from that in the placebo group (2.48\u2009\u00b1\u20092.0\u00a0months) (<jats:italic>p<\/jats:italic>\u2009=\u20090.938). Interestingly, the total distance of movement on the active laser side (2.27\u2009\u00b1\u20091.5\u00a0mm) was significantly greater than that on the placebo side (1.64\u2009\u00b1\u20091.3\u00a0mm) (<jats:italic>p<\/jats:italic>\u2009=\u20090.009). The pain levels on days 1, 2 and 3 were not significantly different between the laser and placebo sections. The rate of distance change toward Class I occlusion in the laser group (1.1\u2009\u00b1\u20090.7\u00a0mm\/month) was significantly higher than that in the placebo group (0.74\u2009\u00b1\u20090.6\u00a0mm\/month) (<jats:italic>p<\/jats:italic>\u2009=\u20090.037). Low-level laser therapy (970\u00a0nm) did not reduce the time needed to obtain Class I occlusion, but a significant acceleration in tooth movement was observed in the irradiated group.<\/jats:p><jats:p>Trial registration: NCT02181439. 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