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This leads to the characteristic pathological changes in the inflammatory cells of COPD patients.\n                    <jats:italic>ADAM33<\/jats:italic>\n                    has been reported to be involved in the pathogenesis of COPD in East Asia by affecting airway inflammation and other immune responses. The aim of this study was to determine the potential role of\n                    <jats:italic>ADAM33<\/jats:italic>\n                    (mRNA and soluble levels) as a biomarker of inflammation in COPD patients. This is a case control study using consecutive sampling. The COPD case and control (non-COPD) groups comprised 37 and 29 patients, respectively. We used univariate analysis to assess differences in the parameters between the groups and bivariate analysis to non-parametrically compare these parameters between the two groups. We observed significantly higher mRNA levels of\n                    <jats:italic>ADAM33<\/jats:italic>\n                    in the COPD patients (10.39\u2009\u00b1\u20091.76) as compared to that in the non-COPD individuals (6.93\u2009\u00b1\u20090.39; P\u2009&lt;\u20090.001). The levels of soluble\n                    <jats:italic>ADAM33<\/jats:italic>\n                    were also significantly higher in the COPD patients (2.188\u2009\u00b1\u20091.142\u00a0ng\/ml) compared to the non-COPD individuals (0.487\u2009\u00b1\u20090.105\u00a0ng\/ml; P\u2009&lt;\u20090.001). The mRNA and soluble\n                    <jats:italic>ADAM33<\/jats:italic>\n                    levels were significantly higher in COPD patients compared to those in the parameter-matched non-COPD individuals. Thus,\n                    <jats:italic>ADAM33<\/jats:italic>\n                    is a potential biomarker and treatment for inflammation in COPD patients.\n                  <\/jats:p>","DOI":"10.1038\/s41598-021-02615-2","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T12:53:32Z","timestamp":1638276812000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The strong correlation between ADAM33 expression and airway inflammation in chronic obstructive pulmonary disease and candidate for biomarker and treatment of COPD"],"prefix":"10.1038","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4429-822X","authenticated-orcid":false,"given":"Muhammad","family":"Fachri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8456-4203","authenticated-orcid":false,"given":"Mochammad","family":"Hatta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nasrum","family":"Massi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif","family":"Santoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri Ariguntar","family":"Wikanningtyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ressy","family":"Dwiyanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ade Rifka","family":"Junita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Reza","family":"Primaguna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Sabir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"2615_CR1","unstructured":"Global Initiative for Chronic Obstructive Pulmonary Disease, Diagnosis and assessment. 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