{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:46:44Z","timestamp":1791524804408,"version":"4.3.4"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T00:00:00Z","timestamp":1638403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["Basic Science Research Program (Grant No. 2018M3C7A1022317)"],"award-info":[{"award-number":["Basic Science Research Program (Grant No. 2018M3C7A1022317)"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["Basic Science Research Program (Grant No. 2018M3C7A1022317)"],"award-info":[{"award-number":["Basic Science Research Program (Grant No. 2018M3C7A1022317)"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dysfunctional thalamocortical interactions have been suggested as putative mechanisms of ineffective pain modulation and also suggested as possible pathophysiology of fibromyalgia (FM). However, it remains unclear which specific thalamocortical networks are altered and whether it is related to abnormal pain perception in people with FM. Here, we conducted combined vertex-wise subcortical shape, cortical thickness, structural covariance, and resting-state functional connectivity analyses to address these questions. FM group exhibited a regional shape deflation of the left posterior thalamus encompassing the ventral posterior lateral and pulvinar nuclei. The structural covariance analysis showed that the extent of regional deflation of the left posterior thalamus was negatively covaried with the left inferior parietal cortical thickness in the FM group, whereas those two regions were positively covaried in the healthy controls. In functional connectivity analysis with the left posterior thalamus as a seed, FM group had less connectivity with the periaqueductal gray compared with healthy controls, but enhanced connectivity between the posterior thalamus and bilateral inferior parietal regions, associated with a lower electrical pain threshold at the hand dorsum (pain-free point). Overall, our findings showed the structural thalamic alteration interacts with the cortical regions in a functionally maladaptive direction, leading the FM brain more responsive to external stimuli and potentially contributing to pain amplification.<\/jats:p>","DOI":"10.1038\/s41598-021-02616-1","type":"journal-article","created":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T11:03:04Z","timestamp":1638442984000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Structural and functional thalamocortical connectivity study in female fibromyalgia"],"prefix":"10.1038","volume":"11","author":[{"given":"Dajung J.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyoel","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June Sic","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Kee","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,12,2]]},"reference":[{"key":"2616_CR1","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/j.pain.0000000000000314","volume":"157","author":"KE Mansfield","year":"2016","unstructured":"Mansfield, K. E., Sim, J., Jordan, J. L. & Jordan, K. P. A systematic review and meta-analysis of the prevalence of chronic widespread pain in the general population. Pain 157, 55\u201364. https:\/\/doi.org\/10.1097\/j.pain.0000000000000314 (2016).","journal-title":"Pain"},{"key":"2616_CR2","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/nrrheum.2011.216","volume":"8","author":"J McBeth","year":"2012","unstructured":"McBeth, J. & Mulvey, M. R. Fibromyalgia: Mechanisms and potential impact of the ACR 2010 classification criteria. Nat. Rev. Rheumatol. 8, 108\u2013116. https:\/\/doi.org\/10.1038\/nrrheum.2011.216 (2012).","journal-title":"Nat. Rev. Rheumatol."},{"key":"2616_CR3","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/nrrheum.2011.98","volume":"7","author":"T Schmidt-Wilcke","year":"2011","unstructured":"Schmidt-Wilcke, T. & Clauw, D. J. Fibromyalgia: From pathophysiology to therapy. Nat. Rev. Rheumatol. 7, 518\u2013527. https:\/\/doi.org\/10.1038\/nrrheum.2011.98 (2011).","journal-title":"Nat. Rev. Rheumatol."},{"key":"2616_CR4","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","volume":"152","author":"CJ Woolf","year":"2011","unstructured":"Woolf, C. J. Central sensitization: Implications for the diagnosis and treatment of pain. Pain 152, S2-15. https:\/\/doi.org\/10.1016\/j.pain.2010.09.030 (2011).","journal-title":"Pain"},{"key":"2616_CR5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.semarthrit.2014.01.001","volume":"44","author":"B Cagnie","year":"2014","unstructured":"Cagnie, B. et al. Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI. Semin. Arthritis Rheum. 44, 68\u201375. https:\/\/doi.org\/10.1016\/j.semarthrit.2014.01.001 (2014).","journal-title":"Semin. Arthritis Rheum."},{"key":"2616_CR6","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.1002\/art.38771","volume":"66","author":"DJ Kim","year":"2014","unstructured":"Kim, D. J. et al. Altered white matter integrity in the corpus callosum in fibromyalgia patients identified by tract-based spatial statistical analysis. Arthritis Rheumatol. 66, 3190\u20133199. https:\/\/doi.org\/10.1002\/art.38771 (2014).","journal-title":"Arthritis Rheumatol."},{"key":"2616_CR7","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3390\/ijerph18041549","volume":"18","author":"JL Leon-Llamas","year":"2021","unstructured":"Leon-Llamas, J. L., Villafaina, S., Murillo-Garcia, A. & Gusi, N. Impact of fibromyalgia in the hippocampal subfields volumes of women\u2014An MRI study. Int. J. Environ. Res. Public Health 18, 1549. https:\/\/doi.org\/10.3390\/ijerph18041549 (2021).","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"2616_CR8","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.jpain.2010.10.003","volume":"12","author":"ME Robinson","year":"2011","unstructured":"Robinson, M. E., Craggs, J. G., Price, D. D., Perlstein, W. M. & Staud, R. Gray matter volumes of pain-related brain areas are decreased in fibromyalgia syndrome. J. Pain 12, 436\u2013443. https:\/\/doi.org\/10.1016\/j.jpain.2010.10.003 (2011).","journal-title":"J. Pain"},{"key":"2616_CR9","doi-asserted-by":"publisher","first-page":"2064","DOI":"10.1038\/s41598-017-18999-z","volume":"8","author":"MK Choe","year":"2018","unstructured":"Choe, M. K., Lim, M., Kim, J. S., Lee, D. S. & Chung, C. K. Disrupted resting state network of fibromyalgia in theta frequency. Sci. Rep. 8, 2064. https:\/\/doi.org\/10.1038\/s41598-017-18999-z (2018).","journal-title":"Sci. Rep."},{"key":"2616_CR10","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1002\/ejp.883","volume":"20","author":"W Choi","year":"2016","unstructured":"Choi, W., Lim, M., Kim, J. S. & Chung, C. K. Habituation deficit of auditory N100m in patients with fibromyalgia. Eur. J. Pain 20, 1634\u20131643. https:\/\/doi.org\/10.1002\/ejp.883 (2016).","journal-title":"Eur. J. Pain"},{"key":"2616_CR11","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1097\/j.pain.0000000000000096","volume":"156","author":"M Lim","year":"2015","unstructured":"Lim, M. et al. Disinhibition of the primary somatosensory cortex in patients with fibromyalgia. Pain 156, 666\u2013674. https:\/\/doi.org\/10.1097\/j.pain.0000000000000096 (2015).","journal-title":"Pain"},{"key":"2616_CR12","doi-asserted-by":"publisher","first-page":"e0151776","DOI":"10.1371\/journal.pone.0151776","volume":"11","author":"M Lim","year":"2016","unstructured":"Lim, M. et al. Augmented pain processing in primary and secondary somatosensory cortex in fibromyalgia: A magnetoencephalography study using intra-epidermal electrical stimulation. PLoS ONE 11, e0151776. https:\/\/doi.org\/10.1371\/journal.pone.0151776 (2016).","journal-title":"PLoS ONE"},{"key":"2616_CR13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/j.pain.0000000000000707","volume":"158","author":"M Lopez-Sola","year":"2017","unstructured":"Lopez-Sola, M. et al. Towards a neurophysiological signature for fibromyalgia. Pain 158, 34\u201347. https:\/\/doi.org\/10.1097\/j.pain.0000000000000707 (2017).","journal-title":"Pain"},{"key":"2616_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13512","author":"M Lim","year":"2021","unstructured":"Lim, M. et al. Functional magnetic resonance imaging signal variability is associated with neuromodulation in fibromyalgia. Neuromodulation https:\/\/doi.org\/10.1111\/ner.13512 (2021).","journal-title":"Neuromodulation"},{"key":"2616_CR15","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/j.pain.0000000000001707","volume":"161","author":"FB Pomares","year":"2020","unstructured":"Pomares, F. B. et al. Upregulation of cortical GABAA receptor concentration in fibromyalgia. Pain 161, 74\u201382. https:\/\/doi.org\/10.1097\/j.pain.0000000000001707 (2020).","journal-title":"Pain"},{"key":"2616_CR16","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1002\/art.33339","volume":"64","author":"BR Foerster","year":"2012","unstructured":"Foerster, B. R. et al. Reduced insular gamma-aminobutyric acid in fibromyalgia. Arthritis Rheum. 64, 579\u2013583. https:\/\/doi.org\/10.1002\/art.33339 (2012).","journal-title":"Arthritis Rheum."},{"key":"2616_CR17","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1097\/j.pain.0000000000000633","volume":"157","author":"A Schrepf","year":"2016","unstructured":"Schrepf, A. et al. Endogenous opioidergic dysregulation of pain in fibromyalgia: A PET and fMRI study. Pain 157, 2217\u20132225. https:\/\/doi.org\/10.1097\/j.pain.0000000000000633 (2016).","journal-title":"Pain"},{"key":"2616_CR18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jocn.2016.12.014","volume":"38","author":"P Sawaddiruk","year":"2017","unstructured":"Sawaddiruk, P., Paiboonworachat, S., Chattipakorn, N. & Chattipakorn, S. C. Alterations of brain activity in fibromyalgia patients. J. Clin. Neurosci. 38, 13\u201322. https:\/\/doi.org\/10.1016\/j.jocn.2016.12.014 (2017).","journal-title":"J. Clin. Neurosci."},{"key":"2616_CR19","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.pain.2009.03.018","volume":"144","author":"KB Jensen","year":"2009","unstructured":"Jensen, K. B. et al. Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain. Pain 144, 95\u2013100. https:\/\/doi.org\/10.1016\/j.pain.2009.03.018 (2009).","journal-title":"Pain"},{"key":"2616_CR20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1744-8069-8-32","volume":"8","author":"KB Jensen","year":"2012","unstructured":"Jensen, K. B. et al. Patients with fibromyalgia display less functional connectivity in the brain\u2019s pain inhibitory network. Mol. Pain 8, 32. https:\/\/doi.org\/10.1186\/1744-8069-8-32 (2012).","journal-title":"Mol. Pain"},{"key":"2616_CR21","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1089\/brain.2014.0274","volume":"4","author":"P Flodin","year":"2014","unstructured":"Flodin, P. et al. Fibromyalgia is associated with decreased connectivity between pain- and sensorimotor brain areas. Brain Connect. 4, 587\u2013594. https:\/\/doi.org\/10.1089\/brain.2014.0274 (2014).","journal-title":"Brain Connect."},{"key":"2616_CR22","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3389\/fnhum.2016.00111","volume":"10","author":"M Lim","year":"2016","unstructured":"Lim, M., Kim, J. S., Kim, D. J. & Chung, C. K. Increased low- and high-frequency oscillatory activity in the prefrontal cortex of fibromyalgia patients. Front. Hum. Neurosci. 10, 111. https:\/\/doi.org\/10.3389\/fnhum.2016.00111 (2016).","journal-title":"Front. Hum. Neurosci."},{"key":"2616_CR23","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0896-6273(01)00582-7","volume":"33","author":"RW Guillery","year":"2002","unstructured":"Guillery, R. W. & Sherman, S. M. Thalamic relay functions and their role in corticocortical communication: Generalizations from the visual system. Neuron 33, 163\u2013175 (2002).","journal-title":"Neuron"},{"key":"2616_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3389\/fnsys.2015.00039","volume":"9","author":"YB Saalmann","year":"2015","unstructured":"Saalmann, Y. B. & Kastner, S. The cognitive thalamus. Front. Syst. Neurosci. 9, 39. https:\/\/doi.org\/10.3389\/fnsys.2015.00039 (2015).","journal-title":"Front. Syst. Neurosci."},{"key":"2616_CR25","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/nn.4269","volume":"19","author":"SM Sherman","year":"2016","unstructured":"Sherman, S. M. Thalamus plays a central role in ongoing cortical functioning. Nat. Neurosci. 19, 533\u2013541. https:\/\/doi.org\/10.1038\/nn.4269 (2016).","journal-title":"Nat. Neurosci."},{"key":"2616_CR26","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s10194-020-01210-6","volume":"22","author":"M Lim","year":"2021","unstructured":"Lim, M., Jassar, H., Kim, D. J., Nascimento, T. D. & DaSilva, A. F. Differential alteration of fMRI signal variability in the ascending trigeminal somatosensory and pain modulatory pathways in migraine. J. Headache Pain 22, 4. https:\/\/doi.org\/10.1186\/s10194-020-01210-6 (2021).","journal-title":"J. Headache Pain"},{"key":"2616_CR27","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1126\/science.1223082","volume":"337","author":"YB Saalmann","year":"2012","unstructured":"Saalmann, Y. B., Pinsk, M. A., Wang, L., Li, X. & Kastner, S. The pulvinar regulates information transmission between cortical areas based on attention demands. Science 337, 753\u2013756. https:\/\/doi.org\/10.1126\/science.1223082 (2012).","journal-title":"Science"},{"key":"2616_CR28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13075-016-0934-0","volume":"18","author":"CM Cummiford","year":"2016","unstructured":"Cummiford, C. M. et al. Changes in resting state functional connectivity after repetitive transcranial direct current stimulation applied to motor cortex in fibromyalgia patients. Arthritis Res. Ther. 18, 40. https:\/\/doi.org\/10.1186\/s13075-016-0934-0 (2016).","journal-title":"Arthritis Res. Ther."},{"key":"2616_CR29","doi-asserted-by":"publisher","first-page":"3960","DOI":"10.1002\/art.24070","volume":"58","author":"J Lutz","year":"2008","unstructured":"Lutz, J. et al. White and gray matter abnormalities in the brain of patients with fibromyalgia: A diffusion-tensor and volumetric imaging study. Arthritis Rheum. 58, 3960\u20133969. https:\/\/doi.org\/10.1002\/art.24070 (2008).","journal-title":"Arthritis Rheum."},{"issue":"Suppl 1","key":"2616_CR30","doi-asserted-by":"publisher","first-page":"S109","DOI":"10.1016\/j.pain.2007.05.010","volume":"132","author":"T Schmidt-Wilcke","year":"2007","unstructured":"Schmidt-Wilcke, T. et al. Striatal grey matter increase in patients suffering from fibromyalgia\u2014A voxel-based morphometry study. Pain 132(Suppl 1), S109-116. https:\/\/doi.org\/10.1016\/j.pain.2007.05.010 (2007).","journal-title":"Pain"},{"key":"2616_CR31","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1093\/cercor\/bhp182","volume":"20","author":"D Zhang","year":"2010","unstructured":"Zhang, D., Snyder, A. Z., Shimony, J. S., Fox, M. D. & Raichle, M. E. Noninvasive functional and structural connectivity mapping of the human thalamocortical system. Cereb. Cortex 20, 1187\u20131194. https:\/\/doi.org\/10.1093\/cercor\/bhp182 (2010).","journal-title":"Cereb. Cortex"},{"key":"2616_CR32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/cercor\/bhh105","volume":"15","author":"H Johansen-Berg","year":"2005","unstructured":"Johansen-Berg, H. et al. Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus. Cereb. Cortex 15, 31\u201339. https:\/\/doi.org\/10.1093\/cercor\/bhh105 (2005).","journal-title":"Cereb. Cortex"},{"key":"2616_CR33","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1038\/nn1075","volume":"6","author":"TE Behrens","year":"2003","unstructured":"Behrens, T. E. et al. Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat. Neurosci. 6, 750\u2013757. https:\/\/doi.org\/10.1038\/nn1075 (2003).","journal-title":"Nat. Neurosci."},{"key":"2616_CR34","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/art.1780330203","volume":"33","author":"F Wolfe","year":"1990","unstructured":"Wolfe, F. et al. The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum. 33, 160\u2013172 (1990).","journal-title":"Arthritis Rheum."},{"key":"2616_CR35","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1136\/jnnp-2011-301484","volume":"83","author":"K Inui","year":"2012","unstructured":"Inui, K. & Kakigi, R. Pain perception in humans: Use of intraepidermal electrical stimulation. J. Neurol. Neurosurg. Psychiatry 83, 551\u2013556. https:\/\/doi.org\/10.1136\/jnnp-2011-301484 (2012).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"2616_CR36","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.neuroimage.2011.02.046","volume":"56","author":"B Patenaude","year":"2011","unstructured":"Patenaude, B., Smith, S. M., Kennedy, D. N. & Jenkinson, M. A Bayesian model of shape and appearance for subcortical brain segmentation. Neuroimage 56, 907\u2013922. https:\/\/doi.org\/10.1016\/j.neuroimage.2011.02.046 (2011).","journal-title":"Neuroimage"},{"key":"2616_CR37","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1002\/hbm.22068","volume":"34","author":"AC Nugent","year":"2013","unstructured":"Nugent, A. C. et al. Automated subcortical segmentation using FIRST: Test\u2013retest reliability, interscanner reliability, and comparison to manual segmentation. Hum. Brain Mapp. 34, 2313\u20132329. https:\/\/doi.org\/10.1002\/hbm.22068 (2013).","journal-title":"Hum. Brain Mapp."},{"key":"2616_CR38","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.neuroimage.2009.10.042","volume":"49","author":"A Krauth","year":"2010","unstructured":"Krauth, A. et al. A mean three-dimensional atlas of the human thalamus: Generation from multiple histological data. Neuroimage 49, 2053\u20132062. https:\/\/doi.org\/10.1016\/j.neuroimage.2009.10.042 (2010).","journal-title":"Neuroimage"},{"key":"2616_CR39","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.neuroimage.2005.03.036","volume":"27","author":"JS Kim","year":"2005","unstructured":"Kim, J. S. et al. Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification. Neuroimage 27, 210\u2013221. https:\/\/doi.org\/10.1016\/j.neuroimage.2005.03.036 (2005).","journal-title":"Neuroimage"},{"key":"2616_CR40","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.neuroimage.2017.12.072","volume":"171","author":"DN Greve","year":"2018","unstructured":"Greve, D. N. & Fischl, B. False positive rates in surface-based anatomical analysis. Neuroimage 171, 6\u201314. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.12.072 (2018).","journal-title":"Neuroimage"},{"key":"2616_CR41","doi-asserted-by":"publisher","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","volume":"8","author":"M Xia","year":"2013","unstructured":"Xia, M., Wang, J. & He, Y. BrainNet Viewer: A network visualization tool for human brain connectomics. PLoS ONE 8, e68910. https:\/\/doi.org\/10.1371\/journal.pone.0068910 (2013).","journal-title":"PLoS ONE"},{"key":"2616_CR42","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","volume":"14","author":"CG Yan","year":"2016","unstructured":"Yan, C. G., Wang, X. D., Zuo, X. N. & Zang, Y. F. DPABI: Data processing & analysis for (resting-state) brain imaging. Neuroinformatics 14, 339\u2013351. https:\/\/doi.org\/10.1007\/s12021-016-9299-4 (2016).","journal-title":"Neuroinformatics"},{"key":"2616_CR43","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1177\/0022034521994089","volume":"100","author":"M Lim","year":"2021","unstructured":"Lim, M., Nascimento, T. D., Kim, D. J., Ellingrod, V. L. & DaSilva, A. F. Aberrant brain signal variability and COMT genotype in chronic TMD patients. J. Dent. Res. 100, 714\u2013722. https:\/\/doi.org\/10.1177\/0022034521994089 (2021).","journal-title":"J. Dent. Res."},{"key":"2616_CR44","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1097\/j.pain.0000000000000665","volume":"157","author":"A Rogachov","year":"2016","unstructured":"Rogachov, A. et al. Regional brain signal variability: A novel indicator of pain sensitivity and coping. Pain 157, 2483\u20132492. https:\/\/doi.org\/10.1097\/j.pain.0000000000000665 (2016).","journal-title":"Pain"},{"key":"2616_CR45","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13041-020-00705-2","volume":"14","author":"J Kong","year":"2021","unstructured":"Kong, J. et al. Altered functional connectivity between hypothalamus and limbic system in fibromyalgia. Mol. Brain. 14, 17. https:\/\/doi.org\/10.1186\/s13041-020-00705-2 (2021).","journal-title":"Mol. Brain."},{"key":"2616_CR46","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini, Y. & Hochberg, Y. Controlling the false discovery rate\u2014A practical and powerful approach to multiple testing. J. R. Stat. Soc. B 57, 289\u2013300. https:\/\/doi.org\/10.1111\/j.2517-6161.1995.tb02031.x (1995).","journal-title":"J. R. Stat. Soc. B"},{"key":"2616_CR47","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.neuroimage.2014.10.044","volume":"105","author":"JD Power","year":"2015","unstructured":"Power, J. D., Schlaggar, B. L. & Petersen, S. E. Recent progress and outstanding issues in motion correction in resting state fMRI. Neuroimage 105, 536\u2013551. https:\/\/doi.org\/10.1016\/j.neuroimage.2014.10.044 (2015).","journal-title":"Neuroimage"},{"key":"2616_CR48","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.acra.2007.03.015","volume":"14","author":"PC Sundgren","year":"2007","unstructured":"Sundgren, P. C. et al. Diffusion-weighted and diffusion tensor imaging in fibromyalgia patients: A prospective study of whole brain diffusivity, apparent diffusion coefficient, and fraction anisotropy in different regions of the brain and correlation with symptom severity. Acad. Radiol. 14, 839\u2013846. https:\/\/doi.org\/10.1016\/j.acra.2007.03.015 (2007).","journal-title":"Acad. Radiol."},{"key":"2616_CR49","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1093\/brain\/awv389","volume":"139","author":"N Vartiainen","year":"2016","unstructured":"Vartiainen, N. et al. Thalamic pain: Anatomical and physiological indices of prediction. Brain J. Neurol. 139, 708\u2013722. https:\/\/doi.org\/10.1093\/brain\/awv389 (2016).","journal-title":"Brain J. Neurol."},{"key":"2616_CR50","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1177\/1073858410396220","volume":"17","author":"A May","year":"2011","unstructured":"May, A. Structural brain imaging: A window into chronic pain. Neurosci. Rev. J. Bringing Neurobiol. Neurol. Psychiatry 17, 209\u2013220. https:\/\/doi.org\/10.1177\/1073858410396220 (2011).","journal-title":"Neurosci. Rev. J. Bringing Neurobiol. Neurol. Psychiatry"},{"key":"2616_CR51","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.tins.2012.06.002","volume":"35","author":"CY Saab","year":"2012","unstructured":"Saab, C. Y. Pain-related changes in the brain: Diagnostic and therapeutic potentials. Trends Neurosci. 35, 629\u2013637. https:\/\/doi.org\/10.1016\/j.tins.2012.06.002 (2012).","journal-title":"Trends Neurosci."},{"key":"2616_CR52","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuroimage.2013.05.054","volume":"80","author":"AC Evans","year":"2013","unstructured":"Evans, A. C. Networks of anatomical covariance. Neuroimage 80, 489\u2013504. https:\/\/doi.org\/10.1016\/j.neuroimage.2013.05.054 (2013).","journal-title":"Neuroimage"},{"key":"2616_CR53","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1002\/hbm.23572","volume":"38","author":"YT Chang","year":"2017","unstructured":"Chang, Y. T. et al. Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white-matter integrity in Alzheimer\u2019s disease. Hum. Brain Mapp. 38, 3039\u20133051. https:\/\/doi.org\/10.1002\/hbm.23572 (2017).","journal-title":"Hum. Brain Mapp."},{"key":"2616_CR54","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/npp.2012.214","volume":"38","author":"H Tost","year":"2013","unstructured":"Tost, H. et al. Effects of the BDNF Val66Met polymorphism on white matter microstructure in healthy adults. Neuropsychopharmacology 38, 525\u2013532. https:\/\/doi.org\/10.1038\/npp.2012.214 (2013).","journal-title":"Neuropsychopharmacology"},{"key":"2616_CR55","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1523\/JNEUROSCI.3554-12.2013","volume":"33","author":"A Alexander-Bloch","year":"2013","unstructured":"Alexander-Bloch, A., Raznahan, A., Bullmore, E. & Giedd, J. The convergence of maturational change and structural covariance in human cortical networks. J Neurosci 33, 2889\u20132899. https:\/\/doi.org\/10.1523\/JNEUROSCI.3554-12.2013 (2013).","journal-title":"J Neurosci"},{"key":"2616_CR56","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","volume":"62","author":"WW Seeley","year":"2009","unstructured":"Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L. & Greicius, M. D. Neurodegenerative diseases target large-scale human brain networks. Neuron 62, 42\u201352. https:\/\/doi.org\/10.1016\/j.neuron.2009.03.024 (2009).","journal-title":"Neuron"},{"key":"2616_CR57","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1093\/cercor\/bhn196","volume":"19","author":"P Bermudez","year":"2009","unstructured":"Bermudez, P., Lerch, J. P., Evans, A. C. & Zatorre, R. J. Neuroanatomical correlates of musicianship as revealed by cortical thickness and voxel-based morphometry. Cereb. Cortex 19, 1583\u20131596. https:\/\/doi.org\/10.1093\/cercor\/bhn196 (2009).","journal-title":"Cereb. Cortex"},{"key":"2616_CR58","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1038\/s41593-017-0020-1","volume":"20","author":"MM Halassa","year":"2017","unstructured":"Halassa, M. M. & Kastner, S. Thalamic functions in distributed cognitive control. Nat. Neurosci. 20, 1669\u20131679. https:\/\/doi.org\/10.1038\/s41593-017-0020-1 (2017).","journal-title":"Nat. Neurosci."},{"key":"2616_CR59","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1002\/hbm.23132","volume":"37","author":"M Dehghan","year":"2016","unstructured":"Dehghan, M. et al. Coordinate-based (ALE) meta-analysis of brain activation in patients with fibromyalgia. Hum. Brain Mapp. 37, 1749\u20131758. https:\/\/doi.org\/10.1002\/hbm.23132 (2016).","journal-title":"Hum. Brain Mapp."},{"key":"2616_CR60","doi-asserted-by":"publisher","DOI":"10.1002\/art.38170","author":"KB Jensen","year":"2013","unstructured":"Jensen, K. B. et al. Overlapping structural and functional brain changes in patients with long-term exposure to fibromyalgia. Arthritis Rheum. https:\/\/doi.org\/10.1002\/art.38170 (2013).","journal-title":"Arthritis Rheum."},{"key":"2616_CR61","doi-asserted-by":"publisher","DOI":"10.1111\/jabr.12137","author":"SE Harte","year":"2018","unstructured":"Harte, S. E., Harris, R. E. & Clauw, D. J. The neurobiology of central sensitization. J. Appl. Biobehav. Res. https:\/\/doi.org\/10.1111\/jabr.12137 (2018).","journal-title":"J. Appl. Biobehav. Res."},{"key":"2616_CR62","doi-asserted-by":"publisher","first-page":"9848","DOI":"10.1523\/JNEUROSCI.1575-14.2015","volume":"35","author":"MJ Arcaro","year":"2015","unstructured":"Arcaro, M. J., Pinsk, M. A. & Kastner, S. The anatomical and functional organization of the human visual pulvinar. J. Neurosci. 35, 9848\u20139871. https:\/\/doi.org\/10.1523\/JNEUROSCI.1575-14.2015 (2015).","journal-title":"J. Neurosci."},{"key":"2616_CR63","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1523\/JNEUROSCI.2104-19.2019","volume":"40","author":"M Lim","year":"2020","unstructured":"Lim, M. et al. Threat prediction from schemas as a source of bias in pain perception. J. Neurosci. 40, 1538\u20131548. https:\/\/doi.org\/10.1523\/JNEUROSCI.2104-19.2019 (2020).","journal-title":"J. Neurosci."},{"key":"2616_CR64","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/j.pain.0000000000001086","volume":"159","author":"SL Yang","year":"2018","unstructured":"Yang, S. L., Wu, T. W. & Tseng, M. T. Vigilance-related attention systems subserve the discrimination of relative intensity differences between painful stimuli. Pain 159, 359\u2013370. https:\/\/doi.org\/10.1097\/j.pain.0000000000001086 (2018).","journal-title":"Pain"},{"key":"2616_CR65","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.3389\/fpsyg.2015.01051","volume":"6","author":"EA Garza-Villarreal","year":"2015","unstructured":"Garza-Villarreal, E. A. et al. Music reduces pain and increases resting state fMRI BOLD signal amplitude in the left angular gyrus in fibromyalgia patients. Front. Psychol. 6, 1051. https:\/\/doi.org\/10.3389\/fpsyg.2015.01051 (2015).","journal-title":"Front. Psychol."},{"key":"2616_CR66","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.cortex.2017.01.010","volume":"89","author":"DM Torta","year":"2017","unstructured":"Torta, D. M., Legrain, V., Mouraux, A. & Valentini, E. Attention to pain! A neurocognitive perspective on attentional modulation of pain in neuroimaging studies. Cortex 89, 120\u2013134. https:\/\/doi.org\/10.1016\/j.cortex.2017.01.010 (2017).","journal-title":"Cortex"},{"key":"2616_CR67","doi-asserted-by":"publisher","first-page":"e2706","DOI":"10.1212\/WNL.0000000000007607","volume":"92","author":"Y Tu","year":"2019","unstructured":"Tu, Y. et al. Abnormal thalamocortical network dynamics in migraine. Neurology 92, e2706\u2013e2716. https:\/\/doi.org\/10.1212\/WNL.0000000000007607 (2019).","journal-title":"Neurology"},{"key":"2616_CR68","doi-asserted-by":"publisher","first-page":"3948","DOI":"10.1038\/s41467-020-17788-z","volume":"11","author":"Y Tu","year":"2020","unstructured":"Tu, Y. et al. Distinct thalamocortical network dynamics are associated with the pathophysiology of chronic low back pain. Nat. Commun. 11, 3948. https:\/\/doi.org\/10.1038\/s41467-020-17788-z (2020).","journal-title":"Nat. Commun."},{"key":"2616_CR69","doi-asserted-by":"publisher","first-page":"7574","DOI":"10.1523\/JNEUROSCI.0174-13.2013","volume":"33","author":"LA Henderson","year":"2013","unstructured":"Henderson, L. A. et al. Chronic pain: Lost inhibition?. J. Neurosci. 33, 7574\u20137582. https:\/\/doi.org\/10.1523\/JNEUROSCI.0174-13.2013 (2013).","journal-title":"J. Neurosci."},{"key":"2616_CR70","doi-asserted-by":"publisher","first-page":"3146","DOI":"10.1002\/art.24849","volume":"60","author":"RE Harris","year":"2009","unstructured":"Harris, R. E. et al. Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis Rheum. 60, 3146\u20133152. https:\/\/doi.org\/10.1002\/art.24849 (2009).","journal-title":"Arthritis Rheum."},{"key":"2616_CR71","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/SPC.0000000000000055","volume":"8","author":"MH Ossipov","year":"2014","unstructured":"Ossipov, M. H., Morimura, K. & Porreca, F. Descending pain modulation and chronification of pain. Curr. Opin. Support Palliat. Care 8, 143\u2013151. https:\/\/doi.org\/10.1097\/SPC.0000000000000055 (2014).","journal-title":"Curr. Opin. Support Palliat. Care"},{"key":"2616_CR72","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/PSY.0b013e3182408f04","volume":"74","author":"I Cifre","year":"2012","unstructured":"Cifre, I. et al. Disrupted functional connectivity of the pain network in fibromyalgia. Psychosom. Med. 74, 55\u201362. https:\/\/doi.org\/10.1097\/PSY.0b013e3182408f04 (2012).","journal-title":"Psychosom. Med."},{"key":"2616_CR73","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1586\/ern.12.41","volume":"12","author":"R Staud","year":"2012","unstructured":"Staud, R. Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev. Neurother. 12, 577\u2013585. https:\/\/doi.org\/10.1586\/ern.12.41 (2012).","journal-title":"Expert Rev. Neurother."},{"key":"2616_CR74","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.pain.2004.02.033","volume":"109","author":"M Valet","year":"2004","unstructured":"Valet, M. et al. Distraction modulates connectivity of the cingulo-frontal cortex and the midbrain during pain\u2014An fMRI analysis. Pain 109, 399\u2013408. https:\/\/doi.org\/10.1016\/j.pain.2004.02.033 (2004).","journal-title":"Pain"},{"issue":"Suppl 2","key":"2616_CR75","first-page":"20","volume":"69","author":"JM Glass","year":"2008","unstructured":"Glass, J. M. Fibromyalgia and cognition. J Clin Psychiatry 69(Suppl 2), 20\u201324 (2008).","journal-title":"J Clin Psychiatry"},{"key":"2616_CR76","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrn3475","volume":"14","author":"KS Button","year":"2013","unstructured":"Button, K. S. et al. Power failure: Why small sample size undermines the reliability of neuroscience. Nat. Rev. Neurosci. 14, 365\u2013376. https:\/\/doi.org\/10.1038\/nrn3475 (2013).","journal-title":"Nat. Rev. Neurosci."},{"key":"2616_CR77","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/jnr.23856","volume":"95","author":"A Gupta","year":"2017","unstructured":"Gupta, A. et al. Sex-based differences in brain alterations across chronic pain conditions. J. Neurosci. Res. 95, 604\u2013616. https:\/\/doi.org\/10.1002\/jnr.23856 (2017).","journal-title":"J. Neurosci. Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-02616-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-02616-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-02616-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T17:54:55Z","timestamp":1670090095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-021-02616-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,2]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["2616"],"URL":"https:\/\/doi.org\/10.1038\/s41598-021-02616-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,2]]},"assertion":[{"value":"28 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23323"}}